Pulmonary function in a cohort of heart-healthy individuals from Northern Sweden-a comparison with discordant reference values.
Clinical physiology
Linear regression
Lung function
Reference values
Spirometry
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
05 Apr 2023
05 Apr 2023
Historique:
received:
03
11
2022
accepted:
29
03
2023
medline:
7
4
2023
entrez:
5
4
2023
pubmed:
6
4
2023
Statut:
epublish
Résumé
Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects. The study population consisted of 285 healthy adults (148 males, 52%) between 20-90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model. No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model based on a larger cohort of Swedish citizens than was available in this study.
Sections du résumé
BACKGROUND
BACKGROUND
Dynamic spirometry is an important investigation to differentiate between impaired and normal lung function. This study aimed to evaluate the results of lung function testing in a cohort of subjects from Northern Sweden without any known heart or pulmonary disease. Our focus was to compare with two reference materials that have showed differences in the age-dependency of lung function in Swedish subjects.
METHODS
METHODS
The study population consisted of 285 healthy adults (148 males, 52%) between 20-90 years of age. The subjects had been randomly selected from the population register for inclusion in a study investigating cardiac function in heart-healthy subjects, but were also assessed with dynamic spirometry. At least seven percent reported smoking. Sixteen subjects presented with pulmonary functional impairments and were excluded from the current study. The sex-specific age-dependency in lung volumes was estimated using the LMS model, where non-linear equations were derived for the mean value (M), the location (L) or skewness, and the scatter (S) or coefficient of variation. This model of the observed lung function data was compared with reference values given by the original LMS model published by the Global Lung Initiative (GLI), and with the model from the recent Obstructive Lung Disease In Norrbotten (OLIN) study, where higher reference values were presented for Swedish subjects than those given by the GLI model.
RESULTS
RESULTS
No differences were found in the age-dependency of pulmonary function between the LMS model developed in the study and the OLIN model. Although the study group included smokers, the original GLI reference values suggested significantly lower normal values of FEV
CONCLUSIONS
CONCLUSIONS
Our results are in line with previous reports and support that the original GLI reference values underestimate pulmonary function in the adult Swedish population. This underestimation could be reduced by updating the coefficients in the underlying LMS model based on a larger cohort of Swedish citizens than was available in this study.
Identifiants
pubmed: 37020237
doi: 10.1186/s12890-023-02403-w
pii: 10.1186/s12890-023-02403-w
pmc: PMC10077603
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110Informations de copyright
© 2023. The Author(s).
Références
Eur Respir J. 2016 Dec;48(6):1602-1611
pubmed: 27824594
Thorax. 2008 Dec;63(12):1046-51
pubmed: 18786983
Bull Eur Physiopathol Respir. 1983 Jul;19 Suppl 5:1-95
pubmed: 6616097
Eur Respir J. 2005 Nov;26(5):948-68
pubmed: 16264058
Eur Respir J. 1999 Jan;13(1):197-205
pubmed: 10836348
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
BMC Pulm Med. 2015 Mar 25;15:26
pubmed: 25887050
Bull Eur Physiopathol Respir. 1985 Nov-Dec;21(6):551-7
pubmed: 4074961
Eur Respir J. 2010 Jul;36(1):12-9
pubmed: 20595163
Echocardiography. 2005 Apr;22(4):305-14
pubmed: 15839985
Eur Respir J. 2016 Nov;48(5):1471-1486
pubmed: 27799391
Eur Respir J. 2012 Dec;40(6):1324-43
pubmed: 22743675
Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88
pubmed: 31613151
Ups J Med Sci. 2021 May 21;126:
pubmed: 34349886
Ups J Med Sci. 1986;91(3):299-310
pubmed: 3811032
BMC Pulm Med. 2018 Jul 18;18(1):118
pubmed: 30021542
Acta Paediatr. 2019 Jul;108(7):1311-1320
pubmed: 30838690
Eur Respir J. 2016 Dec;48(6):1782-1785
pubmed: 27811067
Eur Clin Respir J. 2015 Jul 20;2:
pubmed: 26557250
Multidiscip Respir Med. 2018 Jan 09;13:4
pubmed: 29340151
Eur Respir J. 1996 Dec;9(12):2573-7
pubmed: 8980971
Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36
pubmed: 7663792
Clin Physiol Funct Imaging. 2016 Sep;36(5):346-58
pubmed: 25817817
Am J Respir Crit Care Med. 2002 Sep 1;166(5):675-9
pubmed: 12204864
Eur Respir J. 2002 Nov;20(5):1117-22
pubmed: 12449163
Clin Physiol Funct Imaging. 2017 Nov;37(6):640-645
pubmed: 26865107