Sodium is a negative allosteric regulator of the ghrelin receptor.
CP: Metabolism
CP: Molecular biology
GPCR
NMR
allosteric modulation
fluorescence
ghrelin
molecular dynamics
nanodisc
non-specific binding
sodium
sodium relaxation rate
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
19
04
2022
revised:
09
11
2022
accepted:
14
03
2023
medline:
4
10
2023
pubmed:
8
4
2023
entrez:
7
4
2023
Statut:
ppublish
Résumé
The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment. Among them, sodium ions have been proposed to play a substantial role as endogenous allosteric modulators of GPCR-mediated signaling. However, this sodium effect and the underlying mechanisms are still unclear for most GPCRs. Here, we identified sodium as a negative allosteric modulator of the ghrelin receptor GHSR (growth hormone secretagogue receptor). Combining
Identifiants
pubmed: 37027306
pii: S2211-1247(23)00331-5
doi: 10.1016/j.celrep.2023.112320
pii:
doi:
Substances chimiques
Ghrelin
0
Ions
0
Receptors, Ghrelin
0
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112320Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.