HIV-1 Gag specificity for PIP

gag Gene Products, Human Immunodeficiency Virus / chemistry HIV-1 / metabolism Lipids / chemistry Peptides / metabolism RNA / metabolism Phosphatidylinositol 4,5-Diphosphate
HIV-1 Gag matrix domain Human immunodeficiency virus PIP(2) Protein-RNA interaction Protein-membrane interaction

Journal

Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713

Informations de publication

Date de publication:
06 2023
Historique:
received: 15 12 2022
revised: 14 03 2023
accepted: 29 03 2023
medline: 15 5 2023
pubmed: 8 4 2023
entrez: 7 4 2023
Statut: ppublish

Résumé

HIV-1 assembly occurs at the plasma membrane, with the Gag polyprotein playing a crucial role. Gag association with the membrane is directed by the matrix domain (MA), which is myristoylated and has a highly basic region that interacts with anionic lipids. Several pieces of evidence suggest that the presence of phosphatidylinositol-(4,5)-bisphosphate (PIP

Identifiants

DOI: 10.1016/j.bbamem.2023.184157 PMID: 37028700
pubmed: 37028700
pii: S0005-2736(23)00039-1
doi: 10.1016/j.bbamem.2023.184157
pii:
doi:

Substances chimiques

gag Gene Products, Human Immunodeficiency Virus 0
Lipids 0
Peptides 0
RNA 63231-63-0
Phosphatidylinositol 4,5-Diphosphate 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

184157

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

L B P Socas (LBP)

Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Biológica-Ranwel Caputto, Córdoba, Haya de la Torre y Medina Allende s/n. Córdoba, X5000HUA, Argentina; CONICET. Universidad Nacional de Córdoba, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Córdoba, Haya de la Torre y Medina Allende s/n. Córdoba, X5000HUA, Argentina.

E E Ambroggio (EE)

Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Biológica-Ranwel Caputto, Córdoba, Haya de la Torre y Medina Allende s/n. Córdoba, X5000HUA, Argentina; CONICET. Universidad Nacional de Córdoba, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Córdoba, Haya de la Torre y Medina Allende s/n. Córdoba, X5000HUA, Argentina. Electronic address: eambroggio@unc.edu.ar.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Produits du gène gag › Produits du gène gag du virus de l'immunodéficience humaine › HIV-1 Gag specificity for PIP
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › HIV-1 Gag specificity for PIP
questionsmedicales.fr › Lipides › HIV-1 Gag specificity for PIP
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › HIV-1 Gag specificity for PIP
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › HIV-1 Gag specificity for PIP
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › Phosphatidylinositol diphosphate-4,5 › HIV-1 Gag specificity for PIP