Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Humans
Selective Serotonin Reuptake Inhibitors
Cytochrome P-450 CYP2D6
/ genetics
Cytochrome P-450 CYP2B6
/ genetics
Pharmacogenetics
Depressive Disorder, Major
/ drug therapy
Cytochrome P-450 CYP2C19
/ genetics
Serotonin Plasma Membrane Transport Proteins
/ genetics
Serotonin
Antidepressive Agents
/ therapeutic use
Citalopram
/ therapeutic use
Genotype
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
02
12
2022
accepted:
29
03
2023
pmc-release:
01
07
2024
medline:
20
6
2023
pubmed:
10
4
2023
entrez:
9
4
2023
Statut:
ppublish
Résumé
Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with SSRI-like properties (i.e., vilazodone and vortioxetine) are primary pharmacologic treatments for major depressive and anxiety disorders. Genetic variation in CYP2D6, CYP2C19, and CYP2B6 influences the metabolism of many of these antidepressants, which may potentially affect dosing, efficacy, and tolerability. In addition, the pharmacodynamic genes SLC6A4 (serotonin transporter) and HTR2A (serotonin-2A receptor) have been examined in relation to efficacy and side effect profiles of these drugs. This guideline updates and expands the 2015 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and SSRI dosing and summarizes the impact of CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes on antidepressant dosing, efficacy, and tolerability. We provide recommendations for using CYP2D6, CYP2C19, and CYP2B6 genotype results to help inform prescribing these antidepressants and describe the existing data for SLC6A4 and HTR2A, which do not support their clinical use in antidepressant prescribing.
Identifiants
pubmed: 37032427
doi: 10.1002/cpt.2903
pmc: PMC10564324
mid: NIHMS1920157
doi:
Substances chimiques
Selective Serotonin Reuptake Inhibitors
0
Cytochrome P-450 CYP2D6
EC 1.14.14.1
Cytochrome P-450 CYP2B6
EC 1.14.14.1
Cytochrome P-450 CYP2C19
EC 1.14.14.1
Serotonin Plasma Membrane Transport Proteins
0
Serotonin
333DO1RDJY
Antidepressive Agents
0
Citalopram
0DHU5B8D6V
CYP2B6 protein, human
EC 1.14.14.1
CYP2C19 protein, human
EC 1.14.14.1
SLC6A4 protein, human
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-68Subventions
Organisme : NIGMS NIH HHS
ID : R24 GM115264
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG010135
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD099775
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG010615
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM123930
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001425
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD098757
Pays : United States
Informations de copyright
© 2023 The Authors. Clinical Pharmacology & Therapeutics © 2023 American Society for Clinical Pharmacology and Therapeutics.
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