Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
10 04 2023
10 04 2023
Historique:
received:
24
10
2022
accepted:
21
03
2023
medline:
12
4
2023
entrez:
10
4
2023
pubmed:
11
4
2023
Statut:
epublish
Résumé
Our knowledge of the mechanisms underlying the vulnerability of the brain's white matter microstructure to cardiovascular risk factors (CVRFs) is still limited. We used a quantitative magnetic resonance imaging (MRI) protocol in a single centre setting to investigate the cross-sectional association between CVRFs and brain tissue properties of white matter tracts in a large community-dwelling cohort (n = 1104, age range 46-87 years). Arterial hypertension was associated with lower myelin and axonal density MRI indices, paralleled by higher extracellular water content. Obesity showed similar associations, though with myelin difference only in male participants. Associations between CVRFs and white matter microstructure were observed predominantly in limbic and prefrontal tracts. Additional genetic, lifestyle and psychiatric factors did not modulate these results, but moderate-to-vigorous physical activity was linked to higher myelin content independently of CVRFs. Our findings complement previously described CVRF-related changes in brain water diffusion properties pointing towards myelin loss and neuroinflammation rather than neurodegeneration.
Identifiants
pubmed: 37037939
doi: 10.1038/s42003-023-04741-1
pii: 10.1038/s42003-023-04741-1
pmc: PMC10086032
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
392Informations de copyright
© 2023. The Author(s).
Références
Lancet Neurol. 2012 Mar;11(3):272-82
pubmed: 22341035
Acta Neuropathol Commun. 2013 May 09;1:14
pubmed: 24252608
Neuroimage. 2016 Nov 15;142:394-406
pubmed: 27523449
Eur Heart J. 2019 Jul 21;40(28):2290-2300
pubmed: 30854560
Proc Natl Acad Sci U S A. 2021 May 4;118(18):
pubmed: 33903255
Stroke. 2018 Jun;49(6):1340-1347
pubmed: 29752348
BMC Cardiovasc Disord. 2008 Mar 17;8:6
pubmed: 18366642
Circulation. 2015 Oct 27;132(17):1639-47
pubmed: 26294660
Stroke. 2004 May;35(5):1057-60
pubmed: 15060316
Neurobiol Aging. 2021 Jun;102:50-63
pubmed: 33765431
Neuroimage. 2013 Jun;73:239-54
pubmed: 22846632
Neuroimage Clin. 2018 Jun 20;19:925-938
pubmed: 30003030
Alzheimers Res Ther. 2019 Jan 24;11(1):12
pubmed: 30678723
Neurobiol Aging. 2019 Aug;80:56-70
pubmed: 31103633
Magn Reson Med. 2018 Dec;80(6):2415-2426
pubmed: 29687919
Neuroimage. 2022 Sep;258:119360
pubmed: 35697132
PLoS One. 2012;7(3):e32379
pubmed: 22427831
Sci Rep. 2019 Jan 31;9(1):1060
pubmed: 30705365
J Alzheimers Dis. 2018;62(3):1091-1111
pubmed: 29562540
Neuroimage. 2018 Dec;183:239-253
pubmed: 30086412
Stroke. 2014 Jun;45(6):1721-6
pubmed: 24781079
Magn Reson Med. 2021 Feb;85(2):627-652
pubmed: 32936494
Neuroimage. 2019 Apr 1;189:793-803
pubmed: 30735826
NMR Biomed. 2019 Apr;32(4):e3841
pubmed: 29193413
Front Hum Neurosci. 2016 Dec 08;10:626
pubmed: 28018195
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17648-53
pubmed: 25422429
Neurology. 2017 Oct 31;89(18):1869-1876
pubmed: 28978655
Hum Brain Mapp. 2018 Apr;39(4):1532-1554
pubmed: 29271053
Alzheimers Dement (N Y). 2019 Apr 09;5:107-117
pubmed: 31011621
Neurobiol Aging. 2009 Aug;30(8):1288-95
pubmed: 18077060
BMC Psychiatry. 2009 Mar 17;9:9
pubmed: 19292899
Neuroimage Clin. 2015 Mar 28;8:79-86
pubmed: 26106530
AJNR Am J Neuroradiol. 2010 Aug;31(7):1297-301
pubmed: 20223888
Brain Commun. 2021 Jan 22;3(1):fcaa238
pubmed: 33615218
Nat Commun. 2020 Dec 8;11(1):6285
pubmed: 33293549
Diabetologia. 2012 Oct;55(10):2622-2630
pubmed: 22898763
Brain Imaging Behav. 2020 Oct;14(5):2012-2023
pubmed: 31278650
Neuroimage. 2015 Jan 15;105:32-44
pubmed: 25462697
Arch Gen Psychiatry. 1994 Nov;51(11):849-59; discussion 863-4
pubmed: 7944874
J Cereb Blood Flow Metab. 2018 Feb;38(2):360-372
pubmed: 28857651
Nat Rev Neurol. 2015 Mar;11(3):157-65
pubmed: 25686760
Front Neurosci. 2022 Jan 17;15:818604
pubmed: 35110992
Front Hum Neurosci. 2021 Jul 06;15:662031
pubmed: 34295229
Front Neurosci. 2013 Jun 10;7:95
pubmed: 23772204
J Neurosci. 2011 Jan 19;31(3):1069-80
pubmed: 21248132
Lancet Neurol. 2017 Sep;16(9):730-740
pubmed: 28716371
Neuroimage. 2016 Apr 15;130:157-166
pubmed: 26854557
PLoS One. 2017 Nov 16;12(11):e0187600
pubmed: 29145428
Hum Brain Mapp. 2013 Nov;34(11):2747-66
pubmed: 22611035
Stroke. 2019 Nov;50(11):3037-3044
pubmed: 31510903
Science. 2021 Jun 18;372(6548):
pubmed: 34140357
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Eur Respir J. 2018 Mar 15;51(3):
pubmed: 29449424
Neuroimage Clin. 2017 Aug 15;16:330-342
pubmed: 28861335
Biochim Biophys Acta. 2016 Mar;1862(3):442-51
pubmed: 26499397
Medicine (Baltimore). 2021 Sep 3;100(35):e27015
pubmed: 34477131
Neuroimage Clin. 2019;24:101983
pubmed: 31520917
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255
pubmed: 30718410
J Magn Reson Imaging. 2009 Jan;29(1):198-204
pubmed: 19097114
Aging (Albany NY). 2019 Jul 17;11(14):4923-4942
pubmed: 31315089
Mol Psychiatry. 2021 Sep;26(9):4839-4852
pubmed: 32467648
Nat Commun. 2016 Dec 15;7:13629
pubmed: 27976682
Cereb Cortex. 2022 Feb 8;32(4):839-854
pubmed: 34467389
Brain. 2010 Oct;133(10):3017-29
pubmed: 20851998
Neuroimage. 2012 Jul 16;61(4):1000-16
pubmed: 22484410
Neuroimage. 2002 May;16(1):217-40
pubmed: 11969330
J Neurochem. 2018 Mar;144(5):617-633
pubmed: 29210074
Acta Neuropathol. 2020 Aug;140(2):143-167
pubmed: 32572598
Cerebrovasc Dis. 2014;37(6):423-30
pubmed: 25034465
Hum Brain Mapp. 2019 May;40(7):2252-2268
pubmed: 30673158
Hum Brain Mapp. 2022 Aug 15;43(12):3759-3774
pubmed: 35460147
Physiol Behav. 2018 Apr 1;187:2-5
pubmed: 28823546
Int J Geriatr Psychiatry. 2018 Jan;33(1):14-20
pubmed: 28055136
NMR Biomed. 2019 Apr;32(4):e3778
pubmed: 28886240
Am J Neurodegener Dis. 2016 Nov 30;5(5):171-177
pubmed: 28078193
Neuroimage. 2016 Jan 15;125:36-44
pubmed: 26458514
Magn Reson Med. 2016 Nov;76(5):1574-1581
pubmed: 26745823
Nat Rev Neurosci. 2018 Nov;19(11):701-710
pubmed: 30305711
Nat Neurosci. 2021 Apr;24(4):457-464
pubmed: 33649507
Nat Rev Neurol. 2018 Jul;14(7):387-398
pubmed: 29802354
Neurobiol Aging. 2021 Feb;98:160-172
pubmed: 33290993
Neuroimage. 2021 Oct 1;239:118305
pubmed: 34174392
Elife. 2020 Oct 21;9:
pubmed: 33084576
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Atherosclerosis. 2012 May;222(1):245-50
pubmed: 22420891
Prev Med Rep. 2018 May 15;11:31-36
pubmed: 29984135
Alzheimers Dement. 2020 Sep;16(9):1305-1311
pubmed: 30222945
Circ Cardiovasc Genet. 2015 Apr;8(2):398-409
pubmed: 25663218
Neuroimage. 2014 Dec;103:411-426
pubmed: 25109526
Front Aging Neurosci. 2019 Oct 02;11:270
pubmed: 31632265
Hum Brain Mapp. 2022 Apr 15;43(6):1973-1983
pubmed: 35112434
Magn Reson Med. 2008 Dec;60(6):1396-407
pubmed: 19025906
Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1117-H1136
pubmed: 29393657
Magn Reson Med. 2010 Jul;64(1):229-38
pubmed: 20572153
J Clin Exp Neuropsychol. 2012;34(9):925-35
pubmed: 22905705
Sleep. 2010 Apr;33(4):467-74
pubmed: 20394315