Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology.
COVID-19
bioinformatics
disease markers
ischemic cardiomyopathy
pathogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Mar 2023
30 Mar 2023
Historique:
received:
19
02
2023
revised:
28
03
2023
accepted:
29
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Cardiovascular complications combined with COVID-19 (SARS-CoV-2) lead to a poor prognosis in patients. The common pathogenesis of ischemic cardiomyopathy (ICM) and COVID-19 is still unclear. Here, we explored potential molecular mechanisms and biomarkers for ICM and COVID-19. Common differentially expressed genes (DEGs) of ICM (GSE5406) and COVID-19 (GSE164805) were identified using GEO2R. We performed enrichment and protein-protein interaction analyses and screened key genes. To confirm the diagnostic performance for these hub genes, we used external datasets (GSE116250 and GSE211979) and plotted ROC curves. Transcription factor and microRNA regulatory networks were constructed for the validated hub genes. Finally, drug prediction and molecular docking validation were performed using cMAP. We identified 81 common DEGs, many of which were enriched in terms of their relation to angiogenesis. Three DEGs were identified as key hub genes (
Identifiants
pubmed: 37047484
pii: ijms24076511
doi: 10.3390/ijms24076511
pmc: PMC10094917
pii:
doi:
Substances chimiques
ON 01910
67DOW7F9GL
Vindesine
RSA8KO39WH
MicroRNAs
0
Biomarkers
0
Transcription Factors
0
KLF9 protein, human
0
SRSF1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The National Science Foundation of China
ID : 82074329
Références
Molecules. 2015 Jul 22;20(7):13384-421
pubmed: 26205061
Front Public Health. 2022 Jun 22;10:926069
pubmed: 35812523
J Card Surg. 2020 Aug;35(8):1988-2008
pubmed: 32652713
Heart Rhythm. 2020 Sep;17(9):1463-1471
pubmed: 32387246
Comput Biol Med. 2022 Feb;141:105034
pubmed: 34802714
Methods Mol Biol. 2023;2595:1-12
pubmed: 36441451
PLoS One. 2022 Jun 24;17(6):e0269386
pubmed: 35749386
N Engl J Med. 2020 May 7;382(19):1869
pubmed: 32220200
Biosci Rep. 2021 Oct 29;41(10):
pubmed: 34647577
Int J Gen Med. 2021 Sep 21;14:5927-5937
pubmed: 34584445
Int J Infect Dis. 2020 May;94:91-95
pubmed: 32173574
Front Cardiovasc Med. 2021 Jun 17;8:695206
pubmed: 34222385
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Front Immunol. 2022 Apr 27;13:857573
pubmed: 35572561
Am J Clin Pathol. 2020 May 5;153(6):725-733
pubmed: 32275742
Front Med (Lausanne). 2020 Oct 29;7:573188
pubmed: 33224961
Microvasc Res. 2021 Sep;137:104188
pubmed: 34022205
Physiol Rep. 2020 Sep;8(18):e14578
pubmed: 32975884
Bioinformatics. 2020 Jul 1;36(Suppl_1):i516-i524
pubmed: 32657408
Int J Gen Med. 2022 Mar 04;15:2479-2490
pubmed: 35282650
Angiogenesis. 2022 Feb;25(1):71-86
pubmed: 34170441
Semin Cell Dev Biol. 2020 Mar;99:12-19
pubmed: 30172762
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Carcinogenesis. 2022 Feb 11;43(1):40-51
pubmed: 34490878
Clin Res Cardiol. 2020 May;109(5):531-538
pubmed: 32161990
Brief Bioinform. 2022 May 13;23(3):
pubmed: 35289358
Int J Mol Sci. 2019 Sep 04;20(18):
pubmed: 31487867
J Cell Mol Med. 2021 Nov;25(22):10736-10746
pubmed: 34697898
Circ Res. 2016 Jun 24;119(1):91-112
pubmed: 27340270
Cell. 2017 Nov 30;171(6):1437-1452.e17
pubmed: 29195078
Cancers (Basel). 2019 Feb 07;11(2):
pubmed: 30736462
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Am J Emerg Med. 2020 Jul;38(7):1547.e5-1547.e6
pubmed: 32360119
Genome Biol. 2003;4(5):P3
pubmed: 12734009
Brief Bioinform. 2022 Jul 18;23(4):
pubmed: 35788820
Cureus. 2020 Nov 10;12(11):e11415
pubmed: 33312811
Genome Biol. 2019 Sep 2;20(1):185
pubmed: 31477170
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
Nucleic Acids Res. 2023 Jan 6;51(D1):D638-D646
pubmed: 36370105
JAMA Cardiol. 2020 Jul 1;5(7):802-810
pubmed: 32211816
Nat Rev Genet. 2004 Jul;5(7):545-51
pubmed: 15211356
Mol Biotechnol. 2023 Apr;65(4):612-623
pubmed: 36109428
J Clin Med. 2020 Nov 21;9(11):
pubmed: 33233425
Nucleic Acids Res. 2022 Jul 5;50(W1):W159-W164
pubmed: 35609983
Cytokine Growth Factor Rev. 2021 Feb;57:19-26
pubmed: 33160830
Eur Rev Med Pharmacol Sci. 2021 Oct;25(20):6411-6424
pubmed: 34730223
Nucleic Acids Res. 2019 Jul 2;47(W1):W234-W241
pubmed: 30931480
Nucleic Acids Res. 2023 Jan 6;51(D1):D488-D508
pubmed: 36420884
Int J Mol Sci. 2022 Jan 07;23(2):
pubmed: 35054835
Curr Neurovasc Res. 2020;17(1):11-17
pubmed: 31870262
RNA Biol. 2022 Jan;19(1):963-979
pubmed: 35938548
Front Cardiovasc Med. 2022 Aug 25;9:940808
pubmed: 36093131