Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.

Humans Biomarkers, Tumor / blood Carcinoma, Non-Small-Cell Lung / blood Circulating Tumor DNA / blood Cohort Studies Lung Neoplasms / blood Mutation Neoplasm Metastasis / diagnosis Neoplasm Recurrence, Local / diagnosis Phylogeny Small Cell Lung Carcinoma / pathology Liquid Biopsy

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2023
Historique:
received: 06 04 2022
accepted: 30 01 2023
medline: 21 4 2023
pubmed: 14 4 2023
entrez: 13 4 2023
Statut: ppublish

Résumé

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy

Identifiants

DOI: 10.1038/s41586-023-05776-4 PMID: 37055640 PMC: PMC7614605
pubmed: 37055640
doi: 10.1038/s41586-023-05776-4
pii: 10.1038/s41586-023-05776-4
pmc: PMC7614605
mid: EMS176197
doi:

Substances chimiques

Biomarkers, Tumor 0
Circulating Tumor DNA 0

Banques de données

ClinicalTrials.gov
['NCT01888601']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

553-562

Subventions

Organisme : Cancer Research UK
ID : CTRNBC-2022/100001
Pays : United Kingdom
Organisme : Medical Research Council
ID : CC2041
Pays : United Kingdom
Organisme : Cancer Research UK
ID : CC2041
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 25349
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 21999
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2041
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 24956
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 17786
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A17786
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W025051/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V033077/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29569
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 30025
Pays : United Kingdom

Investigateurs

Jason F Lester (JF)
Amrita Bajaj (A)
Apostolos Nakas (A)
Azmina Sodha-Ramdeen (A)
Keng Ang (K)
Mohamad Tufail (M)
Mohammed Fiyaz Chowdhry (MF)
Molly Scotland (M)
Rebecca Boyles (R)
Sridhar Rathinam (S)
Claire Wilson (C)
Domenic Marrone (D)
Sean Dulloo (S)
Dean A Fennell (DA)
Gurdeep Matharu (G)
Lindsay Primrose (L)
Ekaterini Boleti (E)
Heather Cheyne (H)
Mohammed Khalil (M)
Shirley Richardson (S)
Tracey Cruickshank (T)
Gillian Price (G)
Keith M Kerr (KM)
Sarah Benafif (S)
Kayleigh Gilbert (K)
Babu Naidu (B)
Aya Osman (A)
Christer Lacson (C)
Gerald Langman (G)
Helen Shackleford (H)
Madava Djearaman (M)
Salma Kadiri (S)
Gary Middleton (G)
Angela Leek (A)
Jack Davies Hodgkinson (JD)
Nicola Totten (N)
Angeles Montero (A)
Elaine Smith (E)
Eustace Fontaine (E)
Felice Granato (F)
Helen Doran (H)
Juliette Novasio (J)
Kendadai Rammohan (K)
Leena Joseph (L)
Paul Bishop (P)
Rajesh Shah (R)
Stuart Moss (S)
Vijay Joshi (V)
Philip Crosbie (P)
Kate Brown (K)
Mathew Carter (M)
Anshuman Chaturvedi (A)
Lynsey Priest (L)
Pedro Oliveira (P)
Colin R Lindsay (CR)
Fiona H Blackhall (FH)
Matthew G Krebs (MG)
Yvonne Summers (Y)
Alexandra Clipson (A)
Jonathan Tugwood (J)
Alastair Kerr (A)
Dominic G Rothwell (DG)
Elaine Kilgour (E)
Caroline Dive (C)
Roland F Schwarz (RF)
Tom L Kaufmann (TL)
Gareth A Wilson (GA)
Rachel Rosenthal (R)
Peter Van Loo (P)
Zoltan Szallasi (Z)
Mateo Sokac (M)
Roberto Salgado (R)
Miklos Diossy (M)
Jonas Demeulemeester (J)
Abigail Bunkum (A)
Aengus Stewart (A)
Alastair Magness (A)
Andrew Rowan (A)
Angeliki Karamani (A)
Antonia Toncheva (A)
Benny Chain (B)
Brittany B Campbell (BB)
Carla Castignani (C)
Chris Bailey (C)
Clare E Weeden (CE)
Claudia Lee (C)
Corentin Richard (C)
Cristina Naceur-Lombardelli (C)
David R Pearce (DR)
Despoina Karagianni (D)
Dina Levi (D)
Elena Hoxha (E)
Elizabeth Larose Cadieux (E)
Emma Colliver (E)
Emma Nye (E)
Eva Grönroos (E)
Felip Gálvez-Cancino (F)
Foteini Athanasopoulou (F)
Francisco Gimeno-Valiente (F)
George Kassiotis (G)
Georgia Stavrou (G)
Gerasimos Mastrokalos (G)
Haoran Zhai (H)
Helen L Lowe (HL)
Ignacio Matos (I)
Jacki Goldman (J)
James L Reading (JL)
Javier Herrero (J)
Jayant K Rane (JK)
Jerome Nicod (J)
Jie Min Lam (JM)
John A Hartley (JA)
Karl S Peggs (KS)
Katey S S Enfield (KSS)
Kayalvizhi Selvaraju (K)
Kerstin Thol (K)
Kevin W Ng (KW)
Kezhong Chen (K)
Krijn Dijkstra (K)
Krupa Thakkar (K)
Leah Ensell (L)
Mansi Shah (M)
Marcos Vasquez (M)
Maria Litovchenko (M)
Mariana Werner Sunderland (M)
Mark S Hill (MS)
Michelle Dietzen (M)
Michelle Leung (M)
Mickael Escudero (M)
Mihaela Angelova (M)
Miljana Tanić (M)
Monica Sivakumar (M)
Nnennaya Kanu (N)
Olga Chervova (O)
Olivia Lucas (O)
Othman Al-Sawaf (O)
Paulina Prymas (P)
Philip Hobson (P)
Piotr Pawlik (P)
Richard Kevin Stone (RK)
Robert Bentham (R)
Robert E Hynds (RE)
Roberto Vendramin (R)
Sadegh Saghafinia (S)
Saioa López (S)
Samuel Gamble (S)
Seng Kuong Anakin Ung (SKA)
Sergio A Quezada (SA)
Sharon Vanloo (S)
Simone Zaccaria (S)
Sonya Hessey (S)
Stefan Boeing (S)
Stephan Beck (S)
Supreet Kaur Bola (SK)
Tamara Denner (T)
Teresa Marafioti (T)
Thanos P Mourikis (TP)
Victoria Spanswick (V)
Vittorio Barbè (V)
Wei-Ting Lu (WT)
William Hill (W)
Wing Kin Liu (WK)
Yin Wu (Y)
Yutaka Naito (Y)
Zoe Ramsden (Z)
Catarina Veiga (C)
Gary Royle (G)
Charles-Antoine Collins-Fekete (CA)
Francesco Fraioli (F)
Paul Ashford (P)
Tristan Clark (T)
Martin D Forster (MD)
Siow Ming Lee (SM)
Elaine Borg (E)
Mary Falzon (M)
Dionysis Papadatos-Pastos (D)
James Wilson (J)
Tanya Ahmad (T)
Alexander James Procter (AJ)
Asia Ahmed (A)
Magali N Taylor (MN)
Arjun Nair (A)
David Lawrence (D)
Davide Patrini (D)
Neal Navani (N)
Ricky M Thakrar (RM)
Sam M Janes (SM)
Emilie Martinoni Hoogenboom (E)
Fleur Monk (F)
James W Holding (JW)
Junaid Choudhary (J)
Kunal Bhakhri (K)
Marco Scarci (M)
Martin Hayward (M)
Nikolaos Panagiotopoulos (N)
Pat Gorman (P)
Reena Khiroya (R)
Robert Cm Stephens (RC)
Yien Ning Sophia Wong (YNS)
Steve Bandula (S)
Abigail Sharp (A)
Sean Smith (S)
Nicole Gower (N)
Harjot Kaur Dhanda (HK)
Kitty Chan (K)
Camilla Pilotti (C)
Rachel Leslie (R)
Anca Grapa (A)
Hanyun Zhang (H)
Khalid AbdulJabbar (K)
Xiaoxi Pan (X)
Yinyin Yuan (Y)
David Chuter (D)
Mairead MacKenzie (M)
Serena Chee (S)
Aiman Alzetani (A)
Judith Cave (J)
Lydia Scarlett (L)
Jennifer Richards (J)
Papawadee Ingram (P)
Silvia Austin (S)
Eric Lim (E)
Paulo De Sousa (P)
Simon Jordan (S)
Alexandra Rice (A)
Hilgardt Raubenheimer (H)
Harshil Bhayani (H)
Lyn Ambrose (L)
Anand Devaraj (A)
Hema Chavan (H)
Sofina Begum (S)
Silviu I Buderi (SI)
Daniel Kaniu (D)
Mpho Malima (M)
Sarah Booth (S)
Andrew G Nicholson (AG)
Nadia Fernandes (N)
Pratibha Shah (P)
Chiara Proli (C)
Madeleine Hewish (M)
Sarah Danson (S)
Michael J Shackcloth (MJ)
Lily Robinson (L)
Peter Russell (P)
Kevin G Blyth (KG)
Craig Dick (C)
John Le Quesne (J)
Alan Kirk (A)
Mo Asif (M)
Rocco Bilancia (R)
Nikos Kostoulas (N)
Mathew Thomas (M)

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Christopher Abbosh (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. c.abbosh@ucl.ac.uk.
ORCID: 0000-0002-8983-1382

Alexander M Frankell (AM)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-0341-7878

Thomas Harrison (T)

Invitae, San Francisco, CA, USA.

Judit Kisistok (J)

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.

Aaron Garnett (A)

Invitae, San Francisco, CA, USA.

Laura Johnson (L)

Invitae, San Francisco, CA, USA.

Selvaraju Veeriah (S)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

Mike Moreau (M)

Invitae, San Francisco, CA, USA.

Adrian Chesh (A)

Invitae, San Francisco, CA, USA.

Tafadzwa L Chaunzwa (TL)

Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Jakob Weiss (J)

Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Department of Radiology, Freiburg University Hospital, Freiburg, Germany.

Morgan R Schroeder (MR)

Invitae, San Francisco, CA, USA.

Sophia Ward (S)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Advanced Sequencing Facility, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-6777-5279

Kristiana Grigoriadis (K)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
ORCID: 0000-0002-8435-0176

Aamir Shahpurwalla (A)

Invitae, San Francisco, CA, USA.

Kevin Litchfield (K)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UK.

Clare Puttick (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

Dhruva Biswas (D)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.
ORCID: 0000-0001-9141-5188

Takahiro Karasaki (T)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.
ORCID: 0000-0001-6863-2360

James R M Black (JRM)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

Carlos Martínez-Ruiz (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
ORCID: 0000-0002-4817-0565

Maise Al Bakir (MA)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-0846-8332

Oriol Pich (O)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-1956-1882

Thomas B K Watkins (TBK)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Emilia L Lim (EL)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Ariana Huebner (A)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
ORCID: 0000-0001-8009-4999

David A Moore (DA)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Department of Cellular Pathology, University College London Hospitals, London, UK.
ORCID: 0000-0002-6296-1312

Nadia Godin-Heymann (N)

AstraZeneca, Cambridge, UK.
ORCID: 0000-0003-3260-0302

Anne L'Hernault (A)

AstraZeneca, Cambridge, UK.

Hannah Bye (H)

AstraZeneca, Cambridge, UK.

Aaron Odell (A)

Invitae, San Francisco, CA, USA.

Paula Roberts (P)

Invitae, San Francisco, CA, USA.

Fabio Gomes (F)

The Christie NHS Foundation Trust, Manchester, UK.

Akshay J Patel (AJ)

University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

Elizabeth Manzano (E)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

Crispin T Hiley (CT)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Nicolas Carey (N)

Cancer Research Centre, University of Leicester, Leicester, UK.
ORCID: 0000-0002-2660-9178

Joan Riley (J)

Cancer Research Centre, University of Leicester, Leicester, UK.

Daniel E Cook (DE)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0003-3347-562X

Darren Hodgson (D)

AstraZeneca, Cambridge, UK.

Daniel Stetson (D)

AstraZeneca, Waltham, MA, USA.

J Carl Barrett (JC)

AstraZeneca, Waltham, MA, USA.

Roderik M Kortlever (RM)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-5558-2851

Gerard I Evan (GI)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-0412-1216

Allan Hackshaw (A)

Cancer Research UK & UCL Cancer Trials Centre, London, UK.
ORCID: 0000-0002-5570-5070

Robert D Daber (RD)

Invitae, San Francisco, CA, USA.

Jacqui A Shaw (JA)

Cancer Research Centre, University of Leicester, Leicester, UK.
ORCID: 0000-0003-4227-503X

Hugo J W L Aerts (HJWL)

Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Radiology and Nuclear Medicine, CARIM & GROW, Maastricht University, Maastricht, The Netherlands.
ORCID: 0000-0002-2122-2003

Abel Licon (A)

Invitae, San Francisco, CA, USA.

Josh Stahl (J)

Invitae, San Francisco, CA, USA.

Mariam Jamal-Hanjani (M)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.
Department of Oncology, University College London Hospitals, London, UK.
ORCID: 0000-0003-1212-1259

Nicolai J Birkbak (NJ)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0003-1613-9587

Nicholas McGranahan (N)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
ORCID: 0000-0001-9537-4045

Charles Swanton (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. Charles.Swanton@crick.ac.uk.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. Charles.Swanton@crick.ac.uk.
Department of Oncology, University College London Hospitals, London, UK. Charles.Swanton@crick.ac.uk.
ORCID: 0000-0002-4299-3018

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tracking early lung cancer metastatic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Tracking early lung cancer metastatic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Tracking early lung cancer metastatic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › ADN tumoral circulant › Tracking early lung cancer metastatic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Tracking early lung cancer metastatic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tracking early lung cancer metastatic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Tracking early lung cancer metastatic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Tracking early lung cancer metastatic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Tracking early lung cancer metastatic...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Tracking early lung cancer metastatic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › Tracking early lung cancer metastatic...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Biopsie liquide › Tracking early lung cancer metastatic...