Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions.
Biotransformation
Cyclization
Hopenes
Squalene hopene cyclase
Triterpenoids
Journal
Biotechnology letters
ISSN: 1573-6776
Titre abrégé: Biotechnol Lett
Pays: Netherlands
ID NLM: 8008051
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
25
06
2022
accepted:
14
03
2023
revised:
01
03
2023
medline:
5
5
2023
pubmed:
14
4
2023
entrez:
13
4
2023
Statut:
ppublish
Résumé
Squalene hopene cyclases (SHC) convert squalene, the linear triterpene to fused ring product hopanoid by the cationic cyclization mechanism. The main function of hopanoids, a class of pentacyclic triterpenoids in bacteria involves the maintenance of membrane fluidity and stability. 2, 3-oxido squalene cyclases are functional analogues of SHC in eukaryotes and both these enzymes have fascinated researchers for the high stereo selectivity, complexity, and efficiency they possess. The peculiar property of the enzyme squalene hopene cyclase to accommodate substrates other than its natural substrate can be exploited for the use of these enzymes in an industrial perspective. Here, we present an extensive overview of the enzyme squalene hopene cyclase with emphasis on the cloning and overexpression strategies. An attempt has been made to explore recent research trends around squalene cyclase mediated cyclization reactions of flavour and pharmaceutical significance by using non-natural molecules as substrates.
Identifiants
pubmed: 37055654
doi: 10.1007/s10529-023-03366-y
pii: 10.1007/s10529-023-03366-y
doi:
Substances chimiques
diploptene
1615-91-4
Squalene
7QWM220FJH
Triterpenes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-588Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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