Ethanol-Induced Suppression of G Protein-Gated Inwardly Rectifying K

Mice Animals Basolateral Nuclear Complex / metabolism Ethanol / pharmacology Alcoholism G Protein-Coupled Inwardly-Rectifying Potassium Channels / genetics Mice, Inbred C57BL GTP-Binding Proteins gamma-Aminobutyric Acid
Alcohol Behavior GABA(B) receptor Kir3 Neuroadaptation

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
01 12 2023
Historique:
received: 06 06 2022
revised: 05 04 2023
accepted: 05 04 2023
pmc-release: 15 10 2024
medline: 3 11 2023
pubmed: 18 4 2023
entrez: 17 4 2023
Statut: ppublish

Résumé

The basolateral amygdala (BLA) regulates mood and associative learning and has been linked to the development and persistence of alcohol use disorder. The GABA GABA The somatodendritic inhibitory effect of GABA The ethanol-induced suppression of GIRK-dependent signaling in BA principal neurons contributes to some of the mood-related behaviors associated with ethanol withdrawal in mice. Approaches designed to prevent this neuroadaptation and/or strengthen GIRK-dependent signaling may prove useful for the treatment of alcohol use disorder.

Sections du résumé

BACKGROUND
The basolateral amygdala (BLA) regulates mood and associative learning and has been linked to the development and persistence of alcohol use disorder. The GABA
METHODS
GABA
RESULTS
The somatodendritic inhibitory effect of GABA
CONCLUSIONS
The ethanol-induced suppression of GIRK-dependent signaling in BA principal neurons contributes to some of the mood-related behaviors associated with ethanol withdrawal in mice. Approaches designed to prevent this neuroadaptation and/or strengthen GIRK-dependent signaling may prove useful for the treatment of alcohol use disorder.

Identifiants

DOI: 10.1016/j.biopsych.2023.04.006 PMID: 37068702 PMC: PMC10576835
pubmed: 37068702
pii: S0006-3223(23)01202-7
doi: 10.1016/j.biopsych.2023.04.006
pmc: PMC10576835
mid: NIHMS1893042
pii:
doi:

Substances chimiques

Ethanol 3K9958V90M
G Protein-Coupled Inwardly-Rectifying Potassium Channels 0
GTP-Binding Proteins EC 3.6.1.-
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

863-874

Subventions

Organisme : NIAAA NIH HHS
ID : F31 AA028726
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027544
Pays : United States
Organisme : NIDA NIH HHS
ID : P30 DA048742
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA025978
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007234
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA034696
Pays : United States

Informations de copyright

Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Ezequiel Marron Fernandez de Velasco (E)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota. Electronic address: marro014@umn.edu.

Megan E Tipps (ME)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Bushra Haider (B)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Anna Souders (A)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Carolina Aguado (C)

Departmento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla La Mancha, Campus Biosanitario, La Mancha, Albacete, Spain.

Timothy R Rose (TR)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Baovi N Vo (BN)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Margot C DeBaker (MC)

Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota.

Rafael Luján (R)

Departmento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla La Mancha, Campus Biosanitario, La Mancha, Albacete, Spain.

Kevin Wickman (K)

Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Eucaryotes › Animaux › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Groupe nucléaire basolatéral › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux potassiques rectifiants entrants couplés aux protéines G › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Ethanol-Induced Suppression of G Protein-Gated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Ethanol-Induced Suppression of G Protein-Gated...