The meta-analysis of cytogenetic biomarkers as an assessment of occupational risk for healthcare workers exposed to antineoplastic drugs.
Antineoplastic drug
Cytogenetic damage
Healthcare workers
Meta-analysis
Occupational exposure
Journal
International archives of occupational and environmental health
ISSN: 1432-1246
Titre abrégé: Int Arch Occup Environ Health
Pays: Germany
ID NLM: 7512134
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
16
09
2022
accepted:
07
03
2023
medline:
19
6
2023
pubmed:
20
4
2023
entrez:
20
04
2023
Statut:
ppublish
Résumé
Antineoplastic drugs (ADs) are widely used in clinical practice and have been demonstrated to be effective in treating malignant tumors. However, they carry a risk of cytogenotoxicity for healthcare workers. Studies have reported that genotoxic biomarkers can be applied to assess the occupational health status of healthcare workers at an early stage, but results of different studies are variable. The objectives of the review were examine the association between long-term exposure to ADs and cytogenetic damage to healthcare workers. We systematically reviewed studies between 2005 and 2021 using PubMed, Embase and Web of Science databases that used cytogenetic biomarkers to assess occupational exposure to ADs in healthcare workers. We used RevMan5.4 to analyze the tail length parameters of the DNA, frequency of the chromosomal aberrations, sister chromatid exchanges and micronuclei. A total of 16 studies were included in our study. The studies evaluate the quality of the literature through the Agency for Healthcare Research and Quality. The results revealed that under the random-effects model, the estimated standard deviation was 2.37 (95% confidence interval [CI] 0.92-3.81, P = 0.001) for the tail length parameters of the DNA, 1.48 (95% CI 0.71-2.25, P = 0.0002) for the frequency of chromosomal aberrations, 1.74 (95% CI 0.49-2.99, P = 0.006) for the frequency of sister chromatid exchanges and 1.64 (95% CI 0.83-2.45, P < 0.0001) for the frequency of micronuclei. The results indicate that there is a significant association between occupational exposure to ADs and cytogenetic damage, to which healthcare workers should be alerted.
Identifiants
pubmed: 37079056
doi: 10.1007/s00420-023-01969-6
pii: 10.1007/s00420-023-01969-6
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers
0
Types de publication
Systematic Review
Meta-Analysis
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
785-796Subventions
Organisme : Special fund for Economic and Technological Development of Longgang District, Shenzhen
ID : LGWJ2021-14
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Bi J, Wang R (2018) The comparison of methods on the cytokinesis block micronucleus cell (CB-MNT) detection. Captial J Pub Health 12(02):109–111
Bouraoui S, Brahem A, Tabka F et al (2011a) Assessment of chromosomal aberrations, micronuclei and proliferation rate index in peripheral lymphocytes from Tunisian nurses handling cytotoxic drugs. Environ Toxicol Pharmacol 31(1):250–257
doi: 10.1016/j.etap.2010.11.004
Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
doi: 10.3322/caac.21492
Burgaz S, Karahalil B, Canhi Z et al (2002) Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations. Hum Exp Toxicol 21(3):129–135
doi: 10.1191/0960327102ht230oa
Buschini A, Villarini M, Feretti D et al (2013) Multicentre study for the evaluation of mutagenic/carcinogenic risk in nurses exposed to antineoplastic drugs: assessment of DNA damage. Occup Environ Med 70(11):789–794
doi: 10.1136/oemed-2013-101475
Chen W, Angao Xu, Zhang X (2017) Advances in the study of disease burden of malignant tumors. J Med Theory Pract 30(14):2062–2065
Connor TH, Mcdiarmid MA (2006) Preventing occupational exposures to antineoplastic drugs in health care settings. CA Cancer J Clin 56(6):354–365
doi: 10.3322/canjclin.56.6.354
Connor TH, Debord G, Pretty JR et al (2010) Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers. J Occup Environ Med 52(10):1019–1027
doi: 10.1097/JOM.0b013e3181f72b63
Cornetta T, Padua L, Testa A et al (2008) Molecular biomonitoring of a population of nurses handling antineoplastic drugs. Mutat Res 638(1–2):75–82
doi: 10.1016/j.mrfmmm.2007.08.017
El-Ebiary AA, Abuelfadl AA, Sarhan NI (2013) Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists. J Appl Toxicol 33(3):196–201
doi: 10.1002/jat.1735
Fakher HM, Metwally ES, Rabab Sh E-S (2021) The potential genotoxic effects of antineoplastic drugs in occupationally exposed nurses. Asia Pacific J Med Toxicol 10(1):60–66
Goloni-Bertollo EM, Tajara EH, Manzato AJ et al (1992) Sister chromatid exchanges and chromosome aberrations in lymphocytes of nurses handling antineoplastic drugs. Int J Cancer 50(3):341–344
doi: 10.1002/ijc.2910500302
Huang X, Gao C, Cai W et al (2021a) Effect of occupational exposure to antineoplastic drugs on DNA damage in nurses: a cross-sectional study. Occup Environ Med. https://doi.org/10.1136/oemed-2021-107913
doi: 10.1136/oemed-2021-107913
Huang C, Niu X, Gao C et al (2021b) Micronucleus analysis of peripheral blood lymphocytes in nurses with occupational exposure to antineoplastic drugs. Occup Health 37(04):458–462
Kopjar N, Kasuba V, Rozgaj R et al (2009) The genotoxic risk in health care workers occupationally exposed to cytotoxic drugs–a comprehensive evaluation by the SCE assay. J Environ Sci Health A Tox Hazard Subst Environ Eng 44(5):462–479
doi: 10.1080/10934520902719845
Ladeira C, Viegas S, Pádua M et al (2014) Assessment of genotoxic effects in nurses handling cytostatic drugs. J Toxicol Environ Health Part A Curr Issues 77(14–16):879–887
doi: 10.1080/15287394.2014.910158
Laffon B, Teixeira JP, Silva S et al (2005) Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes. Am J Ind Med 48(2):128–136
doi: 10.1002/ajim.20189
Li L (2017) Risk assessment of health effect on nurse occupationally exposed to antineoplastic drugs in shenzhen hospital. Zunyi Medical University, Zunyi
Mahmoodi M, Soleyman-Jahi S, Zendehdel K et al (2017) Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs. Drug Chem Toxicol 40(2):235–240
doi: 10.1080/01480545.2016.1209678
Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Lisy K, Qureshi R, Mattis P, Mu P (2020) Chapter 7: Systematic reviews of etiology and risk. In: Aromataris E, Munn Z (eds) JBI manual for evidence synthesis. JBI. https://synthesismanual.jbi.global . https://doi.org/10.46658/JBIMES-20-08
Moretti M, Grollino MG, Pavanello S et al (2015) Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach. Int Arch Occup Environ Health 88(6):683–695
doi: 10.1007/s00420-014-0993-y
Rekhadevi PV, Sailaja N, Chandrasekhar M et al (2007) Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs. Mutagenesis 22(6):395–401
doi: 10.1093/mutage/gem032
Roussel C, Witt KL, Shaw PB et al (2019) Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs. Mutat Res Rev Mutat Res 781:207–217
doi: 10.1016/j.mrrev.2017.08.002
Santovito A, Cervella P, Delpero M (2014) Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals. Hum Exp Toxicol 33(9):897–903
doi: 10.1177/0960327113512338
Sasaki M, Dakeishi M, Hoshi S et al (2008) Assessment of DNA damage in Japanese nurses handling antineoplastic drugs by the comet assay. J Occup Health 50(1):7–12
doi: 10.1539/joh.50.7
Shen X, Chen Y, Wen Z et al (2021) Research progress of automated micronucleus analysis technology for cytokinesis arrest. J Radiat Res Radiat 39(03):3–10
Siegel RL, Miller KD, Jemal A (2020) Cancer statistics. CA Cancer J Clin 70(1):7–30
doi: 10.3322/caac.21590
Suspiro A, Prista J (2011) Biomarkers of occupational exposure do anticancer agents: a minireview. Toxicol Lett 207(1):42–52
doi: 10.1016/j.toxlet.2011.08.022
Testa A, Giachelia M, Palma S et al (2007) Occupational exposure to antineoplastic agents induces a high level of chromosome damage. Lack of an effect of GST polymorphisms. Toxicol Appl Pharmacol 223(1):46–55
doi: 10.1016/j.taap.2007.05.006
Ursini CL, Cavallo D, Colombi A et al (2006) Evaluation of early DNA damage in healthcare workers handling antineoplastic drugs. Int Arch Occup Environ Health 80(2):134–140
doi: 10.1007/s00420-006-0111-x
Villarini M, Dominici L, Fatigoni C et al (2012) Biological effect monitoring in peripheral blood lymphocytes from subjects occupationally exposed to antineoplastic drugs: assessment of micronuclei frequency. J Occup Health 54(6):405–415
doi: 10.1539/joh.12-0038-OA
Xiao H (2019) Hazards of chemotherapy drugs to oncology nurses and occupational protection. Chin Commun Dr 35(28):130–132
You Li, Fan Y, Liu Q et al (2010) Study on genetic damage in workers exposed to benzene. Chin J Ind Med 23(03):170–172
Zare Sakhvidi MJ, Hajaghazadeh M, Mostaghaci M et al (2016) Applicability of the comet assay in evaluation of DNA damage in healthcare providers’ working with antineoplastic drugs: a systematic review and meta-analysis. Int J Occup Environ Health 22(1):52–67
doi: 10.1080/10773525.2015.1123380
Zheng Ke, Pan J, Jiang Z et al (2002) The principle of sister chromatid exchange(SCE) detection and its molecular mechanism. Chin J Cell Biol 06:355–359