Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC-MS: relationship between detection and stability.
1,7-lactone
HPLC–MS analysis
N-acetylneuraminic acid
Sialic acids
γ-lactone
Journal
Glycoconjugate journal
ISSN: 1573-4986
Titre abrégé: Glycoconj J
Pays: United States
ID NLM: 8603310
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
06
01
2023
accepted:
30
03
2023
medline:
24
5
2023
pubmed:
21
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
A subclass of the sialic acid family consists of intramolecular lactones that may function as key indicators of physiological and pathological states. However, the existence of these compounds in free form is highly improbable, since they are unlikely to exist in an aqueous solution due to their lability. Current analytical method used to detect them in biological fluids has not recognized their reactivity in solution and is prone to misidentification. However, recent advances in synthetic methods for 1,7-lactones have allowed the preparation of these sialic acid derivatives as authentic reference standards. We report here the development of a new HPLC-MS method for the simultaneous detection of the 1,7-lactone of N-acetylneuraminic acid, its γ-lactone derivative, and N-acetylneuraminic acid that overcomes the limitations of the previous analytical procedure for their identification.
Identifiants
pubmed: 37084126
doi: 10.1007/s10719-023-10114-x
pii: 10.1007/s10719-023-10114-x
pmc: PMC10202997
doi:
Substances chimiques
N-Acetylneuraminic Acid
GZP2782OP0
Sialic Acids
0
Lactones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-354Informations de copyright
© 2023. The Author(s).
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