Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 04 2023
21 04 2023
Historique:
received:
22
02
2022
accepted:
27
03
2023
medline:
25
4
2023
pubmed:
22
4
2023
entrez:
21
04
2023
Statut:
epublish
Résumé
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation technique. Developing an understanding for the donor organ immune cell composition and its dynamic changes during NMP is essential. We aimed for a comprehensive characterization of immune cell (sub)populations, cell trafficking and cytokine release during liver NMP. Single-cell transcriptome profiling of human donor livers prior to, during NMP and after transplantation shows an abundance of CXC chemokine receptor 1
Identifiants
pubmed: 37085477
doi: 10.1038/s41467-023-37674-8
pii: 10.1038/s41467-023-37674-8
pmc: PMC10121614
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2285Informations de copyright
© 2023. The Author(s).
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