Promising applications of red cell distribution width in diagnosis and prognosis of diseases with or without disordered iron metabolism.
disease diagnosis
disordered iron metabolism
ferritin
hepcidin
red cell distribution width
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
revised:
02
04
2023
received:
06
12
2022
accepted:
12
04
2023
medline:
16
6
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well-known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non-anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.
Substances chimiques
Hepcidins
0
Iron
E1UOL152H7
Ferritins
9007-73-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1161-1169Subventions
Organisme : "Taishan Scholars" Program for Young Expert of Shandong Province
ID : tsqn202103105
Organisme : National Natural Science Foundation of China
ID : 22076104
Organisme : National Natural Science Foundation of China
ID : 92043301
Organisme : The "Outstanding University Driven by Talents" Program and Academic Promotion Program of Shandong First Medical University
ID : 2019LJ007
Organisme : The "Outstanding University Driven by Talents" Program and Academic Promotion Program of Shandong First Medical University
ID : 2020LJ002
Informations de copyright
© 2023 International Federation for Cell Biology.
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