Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.
amphiphilic polymer
cellular response
polymer-cell interaction
transcriptome
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 05 2023
02 05 2023
Historique:
medline:
26
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Poly(ethylene oxide) (PEO) and poloxamers, a class of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, have many personal and medical care applications, including the stabilization of stressed cellular membranes. Despite the widespread use, the cellular transcriptional response to these molecules is relatively unknown. C2C12 myoblasts, a model muscle cell, were subjected to short-term Poloxamer 188 (P188) and PEO
Identifiants
pubmed: 37094151
doi: 10.1073/pnas.2219885120
pmc: PMC10161009
doi:
Substances chimiques
Poloxamer
106392-12-5
Ethylene Oxide
JJH7GNN18P
PEO-PPO-PEO
0
Polyethylene Glycols
3WJQ0SDW1A
Polymers
0
Propylene Glycols
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2219885120Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR071349
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122323
Pays : United States
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