Benjamin J Hackel

Affiliations

Department of Chemical Engineering and Materials Science, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA hackel@umn.edu.

ORCID: 0000-0003-3561-9463

Publications (37)

Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models.

Applied and environmental microbiology

Avec: Seth C Ritter , Benjamin J Hackel

Mining and Statistical Modeling of Natural and Variant Class IIa Bacteriocins Elucidate Activity and Selectivity Profiles across Species.

Applied and environmental microbiology

Avec: Daniel T Tresnak , Benjamin J Hackel

Concentration Threshold for Membrane Protection by PEO-PPO Block Copolymers with Variable Molecular Architectures.

ACS applied polymer materials

Avec: Adelyn A Crabtree , Frank S Bates , Benjamin J Hackel

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers.

Skeletal muscle

Avec: Dongwoo Hahn , Joseph D Quick , Brian R Thompson , Adelyn Crabtree , Benjamin J Hackel , Frank S Bates , Joseph M Metzger

Predicting and Interpreting Protein Developability Via Transfer of Convolutional Sequence Representation.

ACS synthetic biology

Avec: Alexander W Golinski , Zachary D Schmitz , Gregory H Nielsen , Bryce Johnson , Diya Saha , Sandhya Appiah , Benjamin J Hackel , Stefano Martiniani

Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.

Langmuir : the ACS journal of surfaces and colloids

Avec: Joseph F Hassler , Megan Lawson , Erika Cerna Arroyo , Frank S Bates , Benjamin J Hackel , Timothy P Lodge

Determinants of Developability and Evolvability of Synthetic Miniproteins as Ligand Scaffolds.

Journal of molecular biology

Avec: Adam McConnell , Sun Li Batten , Benjamin J Hackel

Computationally Aided Discovery of LysEFm5 Variants with Improved Catalytic Activity and Stability.

Applied and environmental microbiology

Avec: Tsvetelina H Baryakova , Seth C Ritter , Daniel T Tresnak , Benjamin J Hackel

Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276.

ACS combinatorial science

Avec: Lawrence A Stern , Patrick S Lown , Alexandra C Kobe , Lotfi Abou-Elkacem , Juergen K Willmann , Benjamin J Hackel

Improved mutant function prediction via PACT: Protein Analysis and Classifier Toolkit.

Bioinformatics (Oxford, England)

Avec: Justin R Klesmith , Benjamin J Hackel

Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers.

The journal of physical chemistry. B

Avec: Wenjia Zhang , Joseph M Metzger , Benjamin J Hackel , Frank S Bates , Timothy P Lodge

A Platform for Deep Sequence-Activity Mapping and Engineering Antimicrobial Peptides.

ACS synthetic biology

Avec: Matthew P DeJong , Seth C Ritter , Katharina A Fransen , Daniel T Tresnak , Alexander W Golinski , Benjamin J Hackel

Engineered protein-small molecule conjugates empower selective enzyme inhibition.

Cell chemical biology

Avec: Andrew K Lewis , Abbigael Harthorn , Sadie M Johnson , Roy R Lobb , Benjamin J Hackel

Systematic Evaluation of Protein-Small Molecule Hybrids on the Yeast Surface.

ACS chemical biology

Avec: Manjie Huang , Marina Rueda-Garcia , Abbigael Harthorn , Benjamin J Hackel , James A Van Deventer

Sequence-activity mapping via depletion reveals striking mutational tolerance and elucidates functional motifs in Tur1a antimicrobial peptide.

Protein engineering, design & selection : PEDS

Avec: Jonathan Collins , Benjamin J Hackel

Affibody-mediated controlled release of fibroblast growth factor 2.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Chiara Bostock , Carter J Teal , Mickael Dang , Alex W Golinski , Benjamin J Hackel , Molly S Shoichet

Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.

Molecular pharmaceutics

Avec: Nagamani Vunnam , MaryJane Been , Evan Huber , Carolyn Paulson , Sophia Szymonski , Benjamin J Hackel , Jonathan N Sachs

Hyperstable Synthetic Mini-Proteins as Effective Ligand Scaffolds.

ACS synthetic biology

Avec: Paul L Blanchard , Brandon J Knick , Sarah A Whelan , Benjamin J Hackel

Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Rakesh Bam , Patrick S Lown , Lawrence A Stern , Karina Sharma , Katheryne E Wilson , Gregory R Bean , Amelie M Lutz , Ramasamy Paulmurugan , Benjamin J Hackel , Jeremy Dahl , Lotfi Abou-Elkacem

Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.

Langmuir : the ACS journal of surfaces and colloids

Avec: Mihee Kim , Frank Heinrich , Greg Haugstad , Guichuan Yu , Guangcui Yuan , Sushil K Satija , Wenjia Zhang , Hannah S Seo , Joseph M Metzger , Samira M Azarin , Timothy P Lodge , Benjamin J Hackel , Frank S Bates

Biophysical Characterization Platform Informs Protein Scaffold Evolvability.

ACS combinatorial science

Avec: Alexander W Golinski , Patrick V Holec , Katelynn M Mischler , Benjamin J Hackel

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.

JACC. Basic to translational science

Avec: Evelyne M Houang , Jason Bartos , Benjamin J Hackel , Timothy P Lodge , Demetris Yannopoulos , Frank S Bates , Joseph M Metzger

Engineering an EGFR-binding Gp2 domain for increased hydrophilicity.

Biotechnology and bioengineering

Avec: Feifan Du , Max A Kruziki , Elizabeth J Zudock , Yi Zhang , Patrick S Lown , Benjamin J Hackel

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density.

Journal of the American Chemical Society

Avec: Clifford M Csizmar , Jacob R Petersburg , Thomas J Perry , Lakmal Rozumalski , Benjamin J Hackel , Carston R Wagner

Influence of Cholesterol and Bilayer Curvature on the Interaction of PPO-PEO Block Copolymers with Liposomes.

Langmuir : the ACS journal of surfaces and colloids

Avec: Wenjia Zhang , McKenzie L Coughlin , Joseph M Metzger , Benjamin J Hackel , Frank S Bates , Timothy P Lodge

Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery.

Biotechnology and bioengineering

Avec: Pin-Kuang Lai , Daniel T Tresnak , Benjamin J Hackel

Anti-CD19 CAR T cells potently redirected to kill solid tumor cells.

PloS one

Avec: Christine Ambrose , Lihe Su , Lan Wu , Fay J Dufort , Thomas Sanford , Alyssa Birt , Benjamin J Hackel , Andreas Hombach , Hinrich Abken , Roy R Lobb , Paul D Rennert

Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand.

Biochemistry

Avec: Nagamani Vunnam , Sophia Szymonski , Petra Hirsova , Gregory J Gores , Jonathan N Sachs , Benjamin J Hackel

Protein engineering via sequence-performance mapping.

Cell systems

Avec: Adam McConnell , Benjamin J Hackel

Effect of Bottlebrush Poloxamer Architecture on Binding to Liposomes.

Biomacromolecules

Avec: Joseph F Hassler , Adelyn Crabtree , Lucy Liberman , Frank S Bates , Benjamin J Hackel , Timothy P Lodge

Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast.

ACS combinatorial science

Avec: Patrick S Lown , Benjamin J Hackel

Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins.

Molecular pharmaceutics

Avec: Justin R Klesmith , Lihe Su , Lan Wu , Ian A Schrack , Fay J Dufort , Alyssa Birt , Christine Ambrose , Benjamin J Hackel , Roy R Lobb , Paul D Rennert

Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer.

Bioconjugate chemistry

Avec: Rakesh Bam , Makenna Laffey , Katharine Nottberg , Patrick S Lown , Benjamin J Hackel , Katheryne E Wilson

Synthesis and Micellization of Bottlebrush Poloxamers.

ACS macro letters

Avec: Joseph F Hassler , Nicholas J Van Zee , Adelyn A Crabtree , Frank S Bates , Benjamin J Hackel , Timothy P Lodge

Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Adelyn A Crabtree , Natalie Boehnke , Frank S Bates , Benjamin J Hackel

Deep Antimicrobial Activity and Stability Analysis Inform Lysin Sequence-Function Mapping.

ACS synthetic biology

Avec: Daniel T Tresnak , Benjamin J Hackel

Sequence-function mapping of proline-rich antimicrobial peptides.

bioRxiv : the preprint server for biology

Avec: Jonathan Collins , Adam McConnell , Zachary D Schmitz , Benjamin J Hackel

Réseau de co-auteurs

Frank S Bates 10 collaborations

Timothy P Lodge 7 collaborations

Daniel T Tresnak 5 collaborations

Joseph M Metzger 5 collaborations

Patrick S Lown 5 collaborations

Seth C Ritter 3 collaborations

Adelyn A Crabtree 3 collaborations

Alexander W Golinski 3 collaborations

Joseph F Hassler 3 collaborations

Adam McConnell 3 collaborations

Wenjia Zhang 3 collaborations

Roy R Lobb 3 collaborations

Adelyn Crabtree 2 collaborations

Zachary D Schmitz 2 collaborations

Lawrence A Stern 2 collaborations

Lotfi Abou-Elkacem 2 collaborations

Justin R Klesmith 2 collaborations

Abbigael Harthorn 2 collaborations

Jonathan Collins 2 collaborations

Nagamani Vunnam 2 collaborations

Sophia Szymonski 2 collaborations

Jonathan N Sachs 2 collaborations

Rakesh Bam 2 collaborations

Katheryne E Wilson 2 collaborations

Christine Ambrose 2 collaborations

Lihe Su 2 collaborations

Lan Wu 2 collaborations

Fay J Dufort 2 collaborations

Alyssa Birt 2 collaborations

Paul D Rennert 2 collaborations

Dongwoo Hahn 1 collaboration

Joseph D Quick 1 collaboration

Brian R Thompson 1 collaboration

Gregory H Nielsen 1 collaboration

Bryce Johnson 1 collaboration

Diya Saha 1 collaboration

Sandhya Appiah 1 collaboration

Stefano Martiniani 1 collaboration

Megan Lawson 1 collaboration

Erika Cerna Arroyo 1 collaboration

Sun Li Batten 1 collaboration

Tsvetelina H Baryakova 1 collaboration

Alexandra C Kobe 1 collaboration

Juergen K Willmann 1 collaboration

Matthew P DeJong 1 collaboration

Katharina A Fransen 1 collaboration

Andrew K Lewis 1 collaboration

Sadie M Johnson 1 collaboration

Manjie Huang 1 collaboration

Marina Rueda-Garcia 1 collaboration

James A Van Deventer 1 collaboration

Chiara Bostock 1 collaboration

Carter J Teal 1 collaboration

Mickael Dang 1 collaboration

Alex W Golinski 1 collaboration

Molly S Shoichet 1 collaboration

MaryJane Been 1 collaboration

Evan Huber 1 collaboration

Carolyn Paulson 1 collaboration

Paul L Blanchard 1 collaboration

Brandon J Knick 1 collaboration

Sarah A Whelan 1 collaboration

Karina Sharma 1 collaboration

Gregory R Bean 1 collaboration

Amelie M Lutz 1 collaboration

Ramasamy Paulmurugan 1 collaboration

Jeremy Dahl 1 collaboration

Mihee Kim 1 collaboration

Frank Heinrich 1 collaboration

Greg Haugstad 1 collaboration

Guichuan Yu 1 collaboration

Guangcui Yuan 1 collaboration

Sushil K Satija 1 collaboration

Hannah S Seo 1 collaboration

Samira M Azarin 1 collaboration

Patrick V Holec 1 collaboration

Katelynn M Mischler 1 collaboration

Evelyne M Houang 1 collaboration

Jason Bartos 1 collaboration

Demetris Yannopoulos 1 collaboration

Feifan Du 1 collaboration

Max A Kruziki 1 collaboration

Elizabeth J Zudock 1 collaboration

Yi Zhang 1 collaboration

Clifford M Csizmar 1 collaboration

Jacob R Petersburg 1 collaboration

Thomas J Perry 1 collaboration

Lakmal Rozumalski 1 collaboration

Carston R Wagner 1 collaboration

McKenzie L Coughlin 1 collaboration

Pin-Kuang Lai 1 collaboration

Thomas Sanford 1 collaboration

Andreas Hombach 1 collaboration

Hinrich Abken 1 collaboration

Petra Hirsova 1 collaboration

Gregory J Gores 1 collaboration

Lucy Liberman 1 collaboration

Ian A Schrack 1 collaboration

Makenna Laffey 1 collaboration

Katharine Nottberg 1 collaboration

Nicholas J Van Zee 1 collaboration

Natalie Boehnke 1 collaboration