A Simulation of the Effects of Diffusion on Hyperpolarized [1-
Journal
IEEE transactions on bio-medical engineering
ISSN: 1558-2531
Titre abrégé: IEEE Trans Biomed Eng
Pays: United States
ID NLM: 0012737
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
pmc-release:
01
10
2024
medline:
4
10
2023
pubmed:
25
4
2023
entrez:
25
4
2023
Statut:
ppublish
Résumé
Hyperpolarized [1- Changes in hyperpolarized pyruvate and lactate signal were calculated using a finite-difference time domain simulation of a two-dimensional tissue model. Signal evolution curves with intracellular k When fitting with the one-compartment model, apparent k This work suggests diffusion is not a significant rate-limiting factor in pyruvate-to-lactate conversion given that our model assumptions hold true. In higher order models, diffusion effects may be accounted for by a term characterizing metabolite transport. Pharmacokinetic models used to analyze hyperpolarized pyruvate signal evolution should focus on carefully selecting the analytical model for fitting rather than accounting for diffusion effects.
Identifiants
pubmed: 37097803
doi: 10.1109/TBME.2023.3269665
pmc: PMC10538435
mid: NIHMS1902765
doi:
Substances chimiques
Pyruvic Acid
8558G7RUTR
Carbon Isotopes
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2905-2913Subventions
Organisme : NCI NIH HHS
ID : R01 CA211150
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA249373
Pays : United States
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