Hyponatraemia and changes in natraemia during hospitalization for acute heart failure and associations with in-hospital and long-term outcomes - from the ESC-HFA EORP Heart Failure Long-Term Registry.
Acute heart failure
Congestion
Hyponatraemia
Prognosis
Sodium
Worsening heart failure
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
29
03
2023
received:
27
12
2022
accepted:
23
04
2023
medline:
23
10
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
ppublish
Résumé
To comprehensively assess hyponatraemia in acute heart failure (AHF) regarding prevalence, associations, hospital course, and post-discharge outcomes. Of 8298 patients in the European Society of Cardiology Heart Failure Long-Term Registry hospitalized for AHF with any ejection fraction, 20% presented with hyponatraemia (serum sodium <135 mmol/L). Independent predictors included lower systolic blood pressure, estimated glomerular filtration rate (eGFR) and haemoglobin, along with diabetes, hepatic disease, use of thiazide diuretics, mineralocorticoid receptor antagonists, digoxin, higher doses of loop diuretics, and non-use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and beta-blockers. In-hospital death occurred in 3.3%. The prevalence of hyponatraemia and in-hospital mortality with different combinations were: 9% hyponatraemia both at admission and discharge (hyponatraemia Yes/Yes, in-hospital mortality 6.9%), 11% Yes/No (in-hospital mortality 4.9%), 8% No/Yes (in-hospital mortality 4.7%), and 72% No/No (in-hospital mortality 2.4%). Correction of hyponatraemia was associated with improvement in eGFR. In-hospital development of hyponatraemia was associated with greater diuretic use and worsening eGFR but also more effective decongestion. Among hospital survivors, 12-month mortality was 19% and adjusted hazard ratios (95% confidence intervals) were for hyponatraemia Yes/Yes 1.60 (1.35-1.89), Yes/No 1.35 (1.14-1.59), and No/Yes 1.18 (0.96-1.45). For death or heart failure hospitalization they were 1.38 (1.21-1.58), 1.17 (1.02-1.33), and 1.09 (0.93-1.27), respectively. Among patients with AHF, 20% had hyponatraemia at admission, which was associated with more advanced heart failure and normalized in half of patients during hospitalization. Admission hyponatraemia (possibly dilutional), especially if it did not resolve, was associated with worse in-hospital and post-discharge outcomes. Hyponatraemia developing during hospitalization (possibly depletional) was associated with lower risk.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1571-1583Investigateurs
Christopher Peter Gale
(CP)
Branko Beleslin
(B)
Andrzej Budaj
(A)
Ovidiu Chioncel
(O)
Nikolaos Dagres
(N)
Nicolas Danchin
(N)
David Erlinge
(D)
Jonathan Emberson
(J)
Michael Glikson
(M)
Alastair Gray
(A)
Meral Kayikcioglu
(M)
Aldo Maggioni
(A)
Klaudia Vivien Nagy
(KV)
Aleksandr Nedoshivin
(A)
Anna-Sonia Petronio
(AS)
Jolien Roos-Hesselink
(J)
Lars Wallentin
(L)
Uwe Zeymer
(U)
M Crespo-Leiro
(M)
S Anker
(S)
A Mebazaa
(A)
A Coats
(A)
G Filippatos
(G)
R Ferrari
(R)
A P Maggioni
(AP)
M F Piepoli
(MF)
A Goda
(A)
M Diez
(M)
A Fernandez
(A)
F Fruhwald
(F)
E Fazlibegovic
(E)
P Gatzov
(P)
A Kurlianskaya
(A)
R Hullin
(R)
T Christodoulides
(T)
J Hradec
(J)
O Wendelboe Nielsen
(OW)
R Nedjar
(R)
T Uuetoa
(T)
M Hassanein
(M)
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(JFD)
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(VP)
D Logeart
(D)
V Chumburidze
(V)
D Tousoulis
(D)
D Milicic
(D)
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E O'Donoghue
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O Amir
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A Shotan
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D Shafie
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M Metra
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A Matsumori
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F Ridocci-Soriano
(F)
D Garcia-Escriva
(D)
A Pellicer-Cabo
(A)
L de la Fuente Galan
(L)
J Lopez Diaz
(JL)
A Recio Platero
(AR)
J C Arias
(JC)
T Blasco-Peiro
(T)
M Sanz Julve
(MS)
E Sanchez-Insa
(E)
C Aured-Guallar
(C)
A Portoles-Ocampo
(A)
M Melin
(M)
E Hägglund
(E)
A Stenberg
(A)
I-M Lindahl
(IM)
B Asserlund
(B)
L Olsson
(L)
U Dahlström
(U)
M Afzelius
(M)
P Karlström
(P)
L Tengvall
(L)
P-A Wiklund
(PA)
B Olsson
(B)
S Kalayci
(S)
A Temizhan
(A)
Y Cavusoglu
(Y)
E Gencer
(E)
M B Yilmaz
(MB)
H Gunes
(H)
Informations de copyright
© 2023 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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