Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Humans Cardiotoxicity Genome-Wide Association Study Heart Failure Cardiomyopathy, Dilated Atrial Fibrillation Neoplasms Glypicans

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
28 04 2023
Historique:
medline: 3 5 2023
pubmed: 1 5 2023
entrez: 1 5 2023
Statut: ppublish

Résumé

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure.

Identifiants

DOI: 10.1126/sciadv.add4984 PMID: 37126556 PMC: PMC10132758
pubmed: 37126556
doi: 10.1126/sciadv.add4984
pmc: PMC10132758
doi:

Substances chimiques

GPC5 protein, human 0
Glypicans 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd4984

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States

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Auteurs

Amand F Schmidt (AF)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
ORCID: 0000-0003-1327-0424

Mimount Bourfiss (M)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0001-5820-4610

Abdulrahman Alasiri (A)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
ORCID: 0000-0003-1450-2936

Esther Puyol-Anton (E)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK.
ORCID: 0000-0002-9789-6629

Sandesh Chopade (S)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.

Marion van Vugt (M)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
ORCID: 0000-0002-6634-1989

Sander W van der Laan (SW)

Central Diagnostics Laboratory, Division Laboratory, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0001-6888-1404

Christian Gross (C)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0002-9482-4259

Chris Clarkson (C)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.

Albert Henry (A)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.
Institute of Health Informatics, Faculty of Population Health, University College London, London, UK.
ORCID: 0000-0001-7422-2288

Tom R Lumbers (TR)

UCL BHF Research Accelerator Centre, London, UK.
Institute of Health Informatics, Faculty of Population Health, University College London, London, UK.
ORCID: 0000-0002-9077-4741

Pim van der Harst (P)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0002-2713-686X

Nora Franceschini (N)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

Joshua C Bis (JC)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3409-1110

Birgitta K Velthuis (BK)

Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0002-2542-9474

Anneline S J M Te Riele (ASJM)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Netherlands Heart Institute, Utrecht, Netherlands.
Member of the European Reference Network for rare, low prevalence, and complex diseases of the heart (ERN GUARD HEART; http://guardheart.ern-net.eu).
ORCID: 0000-0002-4694-4790

Aroon D Hingorani (AD)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.
ORCID: 0000-0001-8365-0081

Bram Ruijsink (B)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK.
ORCID: 0000-0001-8313-5709

Folkert W Asselbergs (FW)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Institute of Health Informatics, Faculty of Population Health, University College London, London, UK.
Member of the European Reference Network for rare, low prevalence, and complex diseases of the heart (ERN GUARD HEART; http://guardheart.ern-net.eu).
ORCID: 0000-0002-1692-8669

Jessica van Setten (J)

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0002-4934-7510

Chris Finan (C)

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
UCL BHF Research Accelerator Centre, London, UK.
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
ORCID: 0000-0002-3319-1937

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questionsmedicales.fr › Tumeurs › Druggable proteins influencing cardiac...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Protéines liées au GPI › Glypicanes › Druggable proteins influencing cardiac...