Never a dull enzyme, RNA polymerase II.
Pol II clusters
Pol II heterogeneity
Pol II subunits
Pol II-associated diseases
RNA polymerases
Journal
Transcription
ISSN: 2154-1272
Titre abrégé: Transcription
Pays: United States
ID NLM: 101530967
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
pmc-release:
02
05
2024
medline:
19
7
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
ppublish
Résumé
RNA polymerase II (Pol II) is composed of 12 subunits that collaborate to synthesize mRNA within the nucleus. Pol II is widely recognized as a passive holoenzyme, with the molecular functions of its subunits largely ignored. Recent studies employing auxin-inducible degron (AID) and multi-omics techniques have revealed that the functional diversity of Pol II is achieved through the differential contributions of its subunits to various transcriptional and post-transcriptional processes. By regulating these processes in a coordinated manner through its subunits, Pol II can optimize its activity for diverse biological functions. Here, we review recent progress in understanding Pol II subunits and their dysregulation in diseases, Pol II heterogeneity, Pol II clusters and the regulatory roles of RNA polymerases.
Identifiants
pubmed: 37132022
doi: 10.1080/21541264.2023.2208023
pmc: PMC10353340
doi:
Substances chimiques
RNA Polymerase II
EC 2.7.7.-
DNA-Directed RNA Polymerases
EC 2.7.7.6
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-67Références
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