Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug.

Humans Mice Animals Hydrolases / metabolism Orlistat / pharmacology Carboxylic Ester Hydrolases / metabolism Anti-Obesity Agents / pharmacology Acebutolol Carboxylesterase / metabolism Pharmaceutical Preparations / metabolism Hydrolysis Drug Interactions

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
08 2023
Historique:
received: 22 01 2023
accepted: 24 04 2023
medline: 17 7 2023
pubmed: 4 5 2023
entrez: 3 5 2023
Statut: ppublish

Résumé

Drug-drug interactions (DDI) have a significant impact on drug efficacy and safety. It has been reported that orlistat, an anti-obesity drug, inhibits the hydrolysis of

Identifiants

DOI: 10.1124/dmd.123.001266 PMID: 37137721
pubmed: 37137721
pii: dmd.123.001266
doi: 10.1124/dmd.123.001266
doi:

Substances chimiques

Hydrolases EC 3.-
Orlistat 95M8R751W8
Carboxylic Ester Hydrolases EC 3.1.1.-
Anti-Obesity Agents 0
Acebutolol 67P356D8GH
Carboxylesterase EC 3.1.1.1
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1016-1023

Informations de copyright

Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Keiya Hirosawa (K)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University (K.H., T.F., Ma.N., Mi.N.) and WPI Nano Life Science Institute, Kanazawa, Japan (T.F., Ma.N., Mi.N.).

Tatsuki Fukami (T)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University (K.H., T.F., Ma.N., Mi.N.) and WPI Nano Life Science Institute, Kanazawa, Japan (T.F., Ma.N., Mi.N.) tatsuki@p.kanazawa-u.ac.jp.

Masataka Nakano (M)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University (K.H., T.F., Ma.N., Mi.N.) and WPI Nano Life Science Institute, Kanazawa, Japan (T.F., Ma.N., Mi.N.).

Miki Nakajima (M)

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University (K.H., T.F., Ma.N., Mi.N.) and WPI Nano Life Science Institute, Kanazawa, Japan (T.F., Ma.N., Mi.N.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Eucaryotes › Animaux › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Orlistat › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents antiobésité › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Propanolamines › Phénoxypropanolamines › Acébutolol › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Carboxylesterase › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Préparations pharmaceutiques › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Phénomènes chimiques › Hydrolyse › Evaluation of Drug-Drug Interactions via...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Evaluation of Drug-Drug Interactions via...