Increased mutation and gene conversion within human segmental duplications.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2023
Historique:
received: 06 07 2022
accepted: 28 02 2023
medline: 12 5 2023
pubmed: 11 5 2023
entrez: 10 5 2023
Statut: ppublish

Résumé

Single-nucleotide variants (SNVs) in segmental duplications (SDs) have not been systematically assessed because of the limitations of mapping short-read sequencing data

Identifiants

pubmed: 37165237
doi: 10.1038/s41586-023-05895-y
pii: 10.1038/s41586-023-05895-y
pmc: PMC10172114
doi:

Substances chimiques

Cytosine 8J337D1HZY
Guanine 5Z93L87A1R

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

325-334

Subventions

Organisme : NIAID NIH HHS
ID : F31 AI150163
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG010262
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010971
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG002385
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133428
Pays : United States
Organisme : NHGRI NIH HHS
ID : R00 HG011041
Pays : United States
Organisme : NHGRI NIH HHS
ID : K99 HG011041
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007454
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010973
Pays : United States

Investigateurs

Haley J Abel (HJ)
Lucinda L Antonacci-Fulton (LL)
Gunjan Baid (G)
Carl A Baker (CA)
Anastasiya Belyaeva (A)
Konstantinos Billis (K)
Guillaume Bourque (G)
Silvia Buonaiuto (S)
Andrew Carroll (A)
Mark J P Chaisson (MJP)
Pi-Chuan Chang (PC)
Xian H Chang (XH)
Haoyu Cheng (H)
Justin Chu (J)
Sarah Cody (S)
Vincenza Colonna (V)
Daniel E Cook (DE)
Robert M Cook-Deegan (RM)
Omar E Cornejo (OE)
Mark Diekhans (M)
Daniel Doerr (D)
Peter Ebert (P)
Jana Ebler (J)
Jordan M Eizenga (JM)
Susan Fairley (S)
Olivier Fedrigo (O)
Adam L Felsenfeld (AL)
Xiaowen Feng (X)
Christian Fischer (C)
Paul Flicek (P)
Giulio Formenti (G)
Adam Frankish (A)
Robert S Fulton (RS)
Yan Gao (Y)
Shilpa Garg (S)
Erik Garrison (E)
Nanibaa' A Garrison (NA)
Carlos Garcia Giron (CG)
Richard E Green (RE)
Cristian Groza (C)
Andrea Guarracino (A)
Leanne Haggerty (L)
Ira M Hall (IM)
Marina Haukness (M)
David Haussler (D)
Simon Heumos (S)
Glenn Hickey (G)
Thibaut Hourlier (T)
Kerstin Howe (K)
Miten Jain (M)
Erich D Jarvis (ED)
Hanlee P Ji (HP)
Eimear E Kenny (EE)
Barbara A Koenig (BA)
Alexey Kolesnikov (A)
Jan O Korbel (JO)
Jennifer Kordosky (J)
Sergey Koren (S)
HoJoon Lee (H)
Heng Li (H)
Wen-Wei Liao (WW)
Shuangjia Lu (S)
Tsung-Yu Lu (TY)
Julian K Lucas (JK)
Hugo Magalhães (H)
Santiago Marco-Sola (S)
Pierre Marijon (P)
Charles Markello (C)
Tobias Marschall (T)
Fergal J Martin (FJ)
Ann McCartney (A)
Jennifer McDaniel (J)
Karen H Miga (KH)
Matthew W Mitchell (MW)
Jean Monlong (J)
Jacquelyn Mountcastle (J)
Moses Njagi Mwaniki (MN)
Maria Nattestad (M)
Adam M Novak (AM)
Sergey Nurk (S)
Hugh E Olsen (HE)
Nathan D Olson (ND)
Benedict Paten (B)
Trevor Pesout (T)
Adam M Phillippy (AM)
Alice B Popejoy (AB)
Pjotr Prins (P)
Daniela Puiu (D)
Mikko Rautiainen (M)
Allison A Regier (AA)
Arang Rhie (A)
Samuel Sacco (S)
Ashley D Sanders (AD)
Valerie A Schneider (VA)
Baergen I Schultz (BI)
Kishwar Shafin (K)
Jonas A Sibbesen (JA)
Jouni Sirén (J)
Michael W Smith (MW)
Heidi J Sofia (HJ)
Ahmad N Abou Tayoun (AN)
Françoise Thibaud-Nissen (F)
Chad Tomlinson (C)
Francesca Floriana Tricomi (FF)
Flavia Villani (F)
Mitchell R Vollger (MR)
Justin Wagner (J)
Brian Walenz (B)
Ting Wang (T)
Jonathan M D Wood (JMD)
Aleksey V Zimin (AV)
Justin M Zook (JM)

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Mitchell R Vollger (MR)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.

Philip C Dishuck (PC)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

William T Harvey (WT)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

William S DeWitt (WS)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA.

Xavi Guitart (X)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Michael E Goldberg (ME)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Allison N Rozanski (AN)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Julian Lucas (J)

UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.

Mobin Asri (M)

UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.

Katherine M Munson (KM)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Alexandra P Lewis (AP)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Kendra Hoekzema (K)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Glennis A Logsdon (GA)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

David Porubsky (D)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Benedict Paten (B)

UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.

Kelley Harris (K)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

PingHsun Hsieh (P)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Evan E Eichler (EE)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA. eee@gs.washington.edu.
Howard Hughes Medical Institute, Chevy Chase, MD, USA. eee@gs.washington.edu.

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Classifications MeSH