Structure and Functions of HMGB2 Protein.
DNA–protein interactions
non-histone protein HMGB2
protein–protein interactions
structure and functions of HMGB2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 May 2023
05 May 2023
Historique:
received:
31
03
2023
revised:
17
04
2023
accepted:
24
04
2023
medline:
15
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
High-Mobility Group (HMG) chromosomal proteins are the most numerous nuclear non-histone proteins. HMGB domain proteins are the most abundant and well-studied HMG proteins. They are involved in variety of biological processes. HMGB1 and HMGB2 were the first members of HMGB-family to be discovered and are found in all studied eukaryotes. Despite the high degree of homology, HMGB1 and HMGB2 proteins differ from each other both in structure and functions. In contrast to HMGB2, there is a large pool of works devoted to the HMGB1 protein whose structure-function properties have been described in detail in our previous review in 2020. In this review, we attempted to bring together diverse data about the structure and functions of the HMGB2 protein. The review also describes post-translational modifications of the HMGB2 protein and its role in the development of a number of diseases. Particular attention is paid to its interaction with various targets, including DNA and protein partners. The influence of the level of HMGB2 expression on various processes associated with cell differentiation and aging and its ability to mediate the differentiation of embryonic and adult stem cells are also discussed.
Identifiants
pubmed: 37176041
pii: ijms24098334
doi: 10.3390/ijms24098334
pmc: PMC10179549
pii:
doi:
Substances chimiques
HMGB2 Protein
0
HMGB1 Protein
0
HMGB Proteins
0
Transcription Factors
0
DNA
9007-49-2
Nuclear Proteins
0
High Mobility Group Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Agreement with the Ministry of Science and Higher Education of the Russian Federation
ID : No. 075-15-2021-1075 of 28 September 2021
Références
FEBS J. 2019 Dec;286(24):4951-4963
pubmed: 31323153
Oncogene. 2019 Apr;38(16):3019-3032
pubmed: 30575817
Biochemistry. 1995 Dec 26;34(51):16596-607
pubmed: 8527432
Oxid Med Cell Longev. 2016;2016:5845061
pubmed: 26682011
Biochem Biophys Res Commun. 2021 Jun 11;557:97-103
pubmed: 33862466
Exp Cell Res. 2006 Nov 1;312(18):3526-38
pubmed: 16962095
Biochem Biophys Res Commun. 1988 May 31;153(1):334-9
pubmed: 3377790
Oncogene. 2013 Jan 17;32(3):363-74
pubmed: 22391561
J Biol Chem. 1990 Nov 15;265(32):19424-8
pubmed: 1700977
Free Radic Biol Med. 2022 Mar;181:14-28
pubmed: 35091064
EMBO J. 1999 Dec 1;18(23):6610-8
pubmed: 10581235
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):101-13
pubmed: 20123072
Biochim Biophys Acta. 1996 Jun 7;1307(2):213-9
pubmed: 8679707
Neoplasia. 2005 Jun;7(6):603-13
pubmed: 16036111
Mol Cells. 2018 Apr 30;41(4):362-372
pubmed: 29487276
Cell Death Dis. 2021 Jul 2;12(7):666
pubmed: 34215724
Mol Cell. 2016 Aug 18;63(4):696-710
pubmed: 27453046
J Biol Chem. 2002 Mar 1;277(9):7157-64
pubmed: 11748232
Int J Cancer. 2006 Nov 1;119(9):2119-26
pubmed: 16823850
Cell. 2009 Jun 26;137(7):1194-211
pubmed: 19563753
Mol Biol (Mosk). 2011 Mar-Apr;45(2):356-65
pubmed: 21634123
Nucleic Acids Res. 2003 Jun 1;31(11):2852-64
pubmed: 12771212
Cell Death Dis. 2015 May 21;6:e1766
pubmed: 25996293
Curr Genomics. 2009 Aug;10(5):294-302
pubmed: 20119526
J Cell Biol. 2016 Nov 7;215(3):325-334
pubmed: 27799366
Cancer Lett. 2010 Jun 1;292(1):125-32
pubmed: 20036050
Dev Biol. 2008 Apr 1;316(1):62-73
pubmed: 18295755
J Theor Biol. 1988 Jun 22;132(4):479-507
pubmed: 3226138
Mol Endocrinol. 2008 May;22(5):1141-53
pubmed: 18218727
Mol Biol (Mosk). 2018 Sep-Oct;52(5):737-749
pubmed: 30363049
Inorg Chem. 2013 Nov 4;52(21):12234-49
pubmed: 23738524
J Biol Chem. 1987 Jan 15;262(2):524-6
pubmed: 3804996
Cancers (Basel). 2020 Aug 27;12(9):
pubmed: 32867128
Mol Cell. 1998 Dec;2(6):829-39
pubmed: 9885570
EMBO J. 1997 May 15;16(10):2665-70
pubmed: 9184213
Cancers (Basel). 2019 Nov 05;11(11):
pubmed: 31694235
Cold Spring Harb Symp Quant Biol. 1993;58:73-81
pubmed: 7956090
Mol Cell Biol. 2002 Apr;22(8):2810-20
pubmed: 11909973
Cell Mol Life Sci. 2007 Oct;64(19-20):2590-606
pubmed: 17599239
Prog Nucleic Acid Res Mol Biol. 1996;54:35-100
pubmed: 8768072
Mol Cell Biol. 2001 Nov;21(22):7537-44
pubmed: 11604490
Mol Med. 2020 May 7;26(1):42
pubmed: 32380958
Science. 1989 Feb 24;243(4894 Pt 1):1056-9
pubmed: 2922595
Nature. 1999 Jun 17;399(6737):708-12
pubmed: 10385126
DNA Repair (Amst). 2019 Nov;83:102701
pubmed: 31563843
Mol Cell. 2018 May 17;70(4):730-744.e6
pubmed: 29706538
PLoS One. 2015 Sep 25;10(9):e0138774
pubmed: 26406975
Nucleic Acids Res. 2012 Nov 1;40(20):10161-71
pubmed: 22941653
Cell Mol Immunol. 2020 Sep;17(9):992-994
pubmed: 32620787
Ann Med. 2021 Dec;53(1):777-785
pubmed: 34042528
Hum Cell. 2018 Jan;31(1):1-9
pubmed: 28916968
Ann Transl Med. 2020 Sep;8(17):1082
pubmed: 33145301
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2209471119
pubmed: 36161922
Dev Dyn. 2018 Jan;247(1):229-238
pubmed: 28771884
Proteomics. 2015 Jan;15(2-3):383-93
pubmed: 25327479
Trends Mol Med. 2006 Jan;12(1):44-52
pubmed: 16325471
Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127
pubmed: 28069585
Genet Mol Biol. 2022 Jan 31;45(1):e20210224
pubmed: 35129574
Adv Clin Exp Med. 2020 Oct;29(10):1153-1160
pubmed: 33064378
J Clin Invest. 2005 Mar;115(3):547-55
pubmed: 15765136
Biochemistry. 1985 Mar 12;24(6):1428-33
pubmed: 2985113
J Mol Biol. 2006 Jun 30;360(1):90-104
pubmed: 16813837
Trends Biochem Sci. 2001 Mar;26(3):167-74
pubmed: 11246022
Medicina (Kaunas). 2020 Mar 19;56(3):
pubmed: 32204562
Int J Mol Sci. 2020 Oct 26;21(21):
pubmed: 33114717
Cancer Biol Ther. 2013 Mar;14(3):213-21
pubmed: 23255232
Biochem Biophys Res Commun. 2013 Nov 29;441(4):701-6
pubmed: 24427810
Mol Cell Biochem. 2012 Apr;363(1-2):65-74
pubmed: 22143534
Semin Cell Dev Biol. 2022 Jan;121:71-81
pubmed: 34119408
Life Sci. 2020 Oct 1;258:118166
pubmed: 32739471
Science. 2009 Aug 14;325(5942):834-40
pubmed: 19608861
Cell Mol Life Sci. 2019 Jan;76(2):211-229
pubmed: 30306212
Cancer Res. 2003 Jan 1;63(1):100-6
pubmed: 12517784
Reproduction. 2013 Nov 21;147(1):125-39
pubmed: 24123129
J Mol Biol. 1995 Sep 29;252(4):423-32
pubmed: 7563062
Int J Mol Sci. 2023 Feb 10;24(4):
pubmed: 36834988
J Mol Biol. 2000 Dec 8;304(4):529-40
pubmed: 11099378
J Proteomics. 2013 Oct 08;91:515-35
pubmed: 23969227
J Cell Biol. 2013 May 13;201(4):613-29
pubmed: 23649808
Mol Cell Biol. 2002 Jun;22(12):4390-401
pubmed: 12024049
J Cell Sci. 2016 Nov 15;129(22):4305-4316
pubmed: 27672022
Clin Proteomics. 2021 Jan 6;18(1):2
pubmed: 33407071
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Biochemistry. 2000 Nov 28;39(47):14426-35
pubmed: 11087395
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):3-14
pubmed: 19748605
Nucleic Acids Res. 2022 Jan 7;50(D1):D439-D444
pubmed: 34791371
Cell. 2021 Jan 7;184(1):76-91.e13
pubmed: 33147444
Bioessays. 1988 Aug-Sep;9(2-3):50-5
pubmed: 3066357
J Steroid Biochem Mol Biol. 2018 Sep;182:127-136
pubmed: 29709634
Biochimie. 2019 Apr;159:49-54
pubmed: 30031036
J Cell Biochem. 2019 Oct;120(10):17345-17353
pubmed: 31209930
Cell. 1997 Apr 4;89(1):43-53
pubmed: 9094713
Biochemistry. 1995 Dec 26;34(51):16608-17
pubmed: 8527433
Pediatr Res. 2002 Aug;52(2):148-54
pubmed: 12149489
J Intern Med. 2004 Mar;255(3):332-43
pubmed: 14871457
Science. 2000 Mar 31;287(5462):2486-92
pubmed: 10741968
Mol Cell Biol. 1999 Oct;19(10):6532-42
pubmed: 10490593
J Mol Biol. 2008 Dec 31;384(5):1262-72
pubmed: 18948112
Nucleus. 2022 Dec;13(1):236-276
pubmed: 36404679
Biochemistry. 1994 Jan 18;33(2):570-5
pubmed: 8286387
DNA Repair (Amst). 2015 Dec;36:122-136
pubmed: 26411874
Structure. 2012 Dec 5;20(12):2014-24
pubmed: 23063560
Front Mol Biosci. 2022 Jul 18;9:844618
pubmed: 35923467
Int J Mol Sci. 2022 Nov 17;23(22):
pubmed: 36430749
J Immunol. 2009 May 1;182(9):5800-9
pubmed: 19380828
Tsitologiia. 2010;52(11):946-9
pubmed: 21268854
Clin Cancer Res. 2010 Nov 15;16(22):5511-21
pubmed: 20851854
Biophys J. 2005 Jul;89(1):353-64
pubmed: 15833996
Biochemistry. 2012 Aug 28;51(34):6728-37
pubmed: 22901013
Nucleic Acids Res. 2017 Sep 29;45(17):9917-9930
pubmed: 28973435
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9465-9
pubmed: 8415724
J Exp Med. 2012 Aug 27;209(9):1519-28
pubmed: 22869893
J Biomed Sci. 2009 Sep 14;16:83
pubmed: 19751520
Development. 2001 Apr;128(8):1265-73
pubmed: 11262228
J Ovarian Res. 2022 Dec 20;15(1):133
pubmed: 36539852
Biochem Genet. 2022 Dec;60(6):2489-2502
pubmed: 35554782
Oncogene. 2009 Aug 13;28(32):2860-72
pubmed: 19503095
J Biochem. 1997 Sep;122(3):586-94
pubmed: 9348088
Mol Cell Proteomics. 2012 Jun;11(6):M111.014258
pubmed: 22270000
Cytokine Growth Factor Rev. 2019 Jun;47:74-82
pubmed: 31129019
J Biol Chem. 2011 Dec 2;286(48):41489-41498
pubmed: 21890638
Nat Commun. 2020 Feb 19;11(1):908
pubmed: 32075966
BMC Pulm Med. 2022 Aug 12;22(1):310
pubmed: 35962344
J Mol Biol. 2000 Nov 24;304(2):135-49
pubmed: 11080451
Redox Biol. 2021 Apr;40:101858
pubmed: 33461096
Oncol Res. 2018 Mar 5;26(2):289-296
pubmed: 28762332
Biochemistry. 1994 Nov 29;33(47):14185-96
pubmed: 7947830
Biomolecules. 2021 Oct 02;11(10):
pubmed: 34680084
J Biol Chem. 2016 Jul 22;291(30):15428-46
pubmed: 27226577
Front Endocrinol (Lausanne). 2018 Jul 03;9:357
pubmed: 30034366
Mol Cell Biol. 1999 Aug;19(8):5237-46
pubmed: 10409715
J Biol Chem. 2003 Nov 28;278(48):47622-8
pubmed: 13129932
Stem Cells. 2013 Jun;31(6):1107-20
pubmed: 23495099
Elife. 2019 Dec 16;8:
pubmed: 31841110
Hepatol Commun. 2017 Oct;1(8):816-830
pubmed: 29218329
Sci Rep. 2018 Jun 25;8(1):9601
pubmed: 29942000
Oncogene. 2015 Jul;34(29):3871-80
pubmed: 25284587
Biochemistry. 1999 Jan 12;38(2):589-95
pubmed: 9888798
EMBO J. 1996 Sep 16;15(18):4981-91
pubmed: 8890171
Am J Hum Genet. 1998 Dec;63(6):1573-7
pubmed: 9837808
Nucleic Acids Res. 1996 Mar 15;24(6):1047-51
pubmed: 8604337
Mol Cell Biol. 2002 Oct;22(19):6797-808
pubmed: 12215537
Cancers (Basel). 2022 Oct 05;14(19):
pubmed: 36230798
Cell Commun Signal. 2018 Feb 20;16(1):8
pubmed: 29463261
J Mol Biol. 2007 Dec 7;374(4):993-1004
pubmed: 17964600
PLoS Pathog. 2019 Jan 30;15(1):e1007578
pubmed: 30699189
J Agric Food Chem. 2019 Apr 24;67(16):4700-4708
pubmed: 30929441
Nucleic Acids Res. 1993 Jul 25;21(15):3427-36
pubmed: 8346022
Can J Physiol Pharmacol. 2019 Mar;97(3):206-212
pubmed: 30485131
Ther Adv Med Oncol. 2020 Nov 10;12:1758835920970850
pubmed: 33224279
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1181-6
pubmed: 19139395
FASEB J. 2020 Sep;34(9):12367-12378
pubmed: 32686868
J Anat. 2003 Jun;202(6):495-502
pubmed: 12846471
Gut. 2006 Feb;55(2):234-42
pubmed: 16118352
Genes Dev. 1998 Feb 15;12(4):462-72
pubmed: 9472015
EMBO J. 1995 Mar 15;14(6):1198-208
pubmed: 7720710
Front Cell Dev Biol. 2014 Mar 06;2:5
pubmed: 25364713
Mol Biol Cell. 2003 Aug;14(8):3414-26
pubmed: 12925773
Horm Cancer. 2014 Jun;5(3):127-39
pubmed: 24718937
Ir J Med Sci. 2022 Feb;191(1):155-162
pubmed: 33635447
Biochem Biophys Res Commun. 1995 May 25;210(3):1045-51
pubmed: 7763232
Biol Reprod. 2021 Dec 20;105(6):1510-1520
pubmed: 34719720
J Cell Physiol. 2019 Dec;234(12):23518-23527
pubmed: 31219186
Nat Genet. 1999 Jul;22(3):276-80
pubmed: 10391216
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16817-22
pubmed: 19805379
J Clin Lab Anal. 2022 May;36(5):e24381
pubmed: 35403252
Sci Rep. 2019 Mar 7;9(1):3786
pubmed: 30846811
Eur J Biochem. 1998 May 1;253(3):787-95
pubmed: 9654080
Hum Pathol. 2019 Feb;84:133-141
pubmed: 30296520
Mol Cell. 2016 Oct 20;64(2):416-430
pubmed: 27768875
Mol Cell Biol. 1998 Aug;18(8):4471-87
pubmed: 9671457
Genes Dev. 2006 Dec 15;20(24):3347-65
pubmed: 17182864
Neuro Oncol. 2013 Sep;15(9):1264-75
pubmed: 23828241
Biochemistry. 1999 Sep 14;38(37):12150-8
pubmed: 10508419
Biomolecules. 2020 Oct 15;10(10):
pubmed: 33076532
Nature. 1982 Nov 4;300(5887):76-8
pubmed: 6215587
Sci Rep. 2022 Jul 13;12(1):11962
pubmed: 35831365
Circ J. 2019 Jan 25;83(2):368-378
pubmed: 30487376
Haematologica. 2020 Mar;105(3):573-584
pubmed: 31171637
PLoS One. 2014 Feb 13;9(2):e89070
pubmed: 24551219
Front Neurosci. 2022 May 24;16:813430
pubmed: 35685777
J Mol Biol. 2010 Nov 12;403(5):706-22
pubmed: 20691192
J Mol Biol. 2007 Dec 14;374(5):1286-97
pubmed: 17988686
Histochem Cell Biol. 2022 Mar;157(3):359-369
pubmed: 35024954
Elife. 2016 Nov 19;5:
pubmed: 27855781
Curr Med Chem. 2020;27(20):3271-3289
pubmed: 30674244
EMBO J. 2003 Oct 15;22(20):5551-60
pubmed: 14532127