Pathological potential of oligodendrocyte precursor cells: terra incognita.

Oligodendrocyte Precursor Cells / physiology Central Nervous System Neuroglia Remyelination / physiology Oligodendroglia / physiology Cell Differentiation / physiology Myelin Sheath / physiology
OPC aging neurodegenerative disease neuroinflammation psychiatric disorders traumatic brain injury

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
07 2023
Historique:
received: 08 01 2023
revised: 12 03 2023
accepted: 13 04 2023
medline: 23 6 2023
pubmed: 15 5 2023
entrez: 14 5 2023
Statut: ppublish

Résumé

Adult oligodendrocyte precursor cells (aOPCs), transformed from fetal OPCs, are idiosyncratic neuroglia of the central nervous system (CNS) that are distinct in many ways from other glial cells. OPCs have been classically studied in the context of their remyelinating capacity. Recent studies, however, revealed that aOPCs not only contribute to post-lesional remyelination but also play diverse crucial roles in multiple neurological diseases. In this review we briefly present the physiology of aOPCs and summarize current knowledge of the beneficial and detrimental roles of aOPCs in different CNS diseases. We discuss unique features of aOPC death, reactivity, and changes during senescence, as well as aOPC interactions with other glial cells and pathological remodeling during disease. Finally, we outline future perspectives for the study of aOPCs in brain pathologies which may instigate the development of aOPC-targeting therapeutic strategies.

Identifiants

DOI: 10.1016/j.tins.2023.04.003 PMID: 37183154
pubmed: 37183154
pii: S0166-2236(23)00103-0
doi: 10.1016/j.tins.2023.04.003
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

581-596

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no conflicts of interest.

Auteurs

Chenju Yi (C)

Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China; Department of Pathology, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China; Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research, Shenzhen 518107, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. Electronic address: yichj@mail.sysu.edu.cn.

Alexei Verkhratsky (A)

Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK; Achucarro Centre for Neuroscience, Basque Foundation for Science (IKERBASQUE), Bilbao 48011, Spain; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01102 Vilnius, Lithuania; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. Electronic address: Alexej.Verkhratsky@manchester.ac.uk.

Jianqin Niu (J)

Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, Chongqing 400038, China. Electronic address: jianqinniu@tmmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Précurseurs des oligodendrocytes › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Système nerveux › Système nerveux central › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Cellules › Névroglie › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Remyélinisation › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Pathological potential of oligodendrocyte...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Pathological potential of oligodendrocyte...