Lysine catabolism reprograms tumour immunity through histone crotonylation.

Chromatin / chemistry Glutaryl-CoA Dehydrogenase / metabolism Histones / chemistry Lysine / deficiency Protein Processing, Post-Translational Neoplasms / drug therapy RNA, Double-Stranded / immunology Humans Animals Mice Interferon Type I / immunology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2023
Historique:
received: 27 07 2022
accepted: 06 04 2023
medline: 26 5 2023
pubmed: 18 5 2023
entrez: 17 5 2023
Statut: ppublish

Résumé

Cancer cells rewire metabolism to favour the generation of specialized metabolites that support tumour growth and reshape the tumour microenvironment

Identifiants

DOI: 10.1038/s41586-023-06061-0 PMID: 37198486
pubmed: 37198486
doi: 10.1038/s41586-023-06061-0
pii: 10.1038/s41586-023-06061-0
doi:

Substances chimiques

Chromatin 0
Glutaryl-CoA Dehydrogenase EC 1.3.8.6
Histones 0
Lysine K3Z4F929H6
crotonyl-coenzyme A 992-67-6
SLC7A2 protein, human 0
ECHS1 protein, human EC 4.2.1.17
bone sialoprotein (35-62), human 0
RNA, Double-Stranded 0
IFIH1 protein, human EC 3.6.1.-
cGAS protein, human EC 2.7.7.-
Interferon Type I 0
MYC protein, human 0
PDCD1 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

818-826

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM132261
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238662
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103434
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197718
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA251677
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135504
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Huairui Yuan (H)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Xujia Wu (X)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
ORCID: 0000-0002-6904-0778

Qiulian Wu (Q)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Adam Chatoff (A)

Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Emily Megill (E)

Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Jinjun Gao (J)

Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.

Tengfei Huang (T)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Tingting Duan (T)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
ORCID: 0000-0002-4482-5587

Kailin Yang (K)

Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.

Chunyu Jin (C)

Department and School of Medicine, University of California, San Diego, CA, USA.

Fanen Yuan (F)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Shuai Wang (S)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Linjie Zhao (L)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Pascal O Zinn (PO)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Kalil G Abdullah (KG)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Yingming Zhao (Y)

Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.

Nathaniel W Snyder (NW)

Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
ORCID: 0000-0001-5643-8747

Jeremy N Rich (JN)

Hillman Cancer Center and Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.
Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.
ORCID: 0000-0001-7845-5302

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Glutaryl-CoA dehydrogenase › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Tumeurs › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Eucaryotes › Animaux › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lysine catabolism reprograms tumour immunity...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Lysine catabolism reprograms tumour immunity...