Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis.

Mycobacterium tuberculosis Acyl Carrier Protein / pharmacology Isatin / pharmacology Molecular Docking Simulation Oxidoreductases / metabolism Antitubercular Agents / chemistry Pyrimidines / pharmacology Bacterial Proteins / metabolism Microbial Sensitivity Tests
Enoyl acyl carrier protein (ACP) reductase InhA inhibitors Isatin Molecular docking Molecular dynamics Molecular hybridization Mycobacterium tuberculosis Pyrimidine

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
09 2023
Historique:
received: 13 02 2023
revised: 20 04 2023
accepted: 02 05 2023
medline: 10 7 2023
pubmed: 19 5 2023
entrez: 18 5 2023
Statut: ppublish

Résumé

Tuberculosis is a worldwide problem that impose a burden on the economy due to continuous development of resistant strains. The development of new antitubercular drugs is a need and can be achieved through inhibition of druggable targets. Mycobacterium tuberculosis enoyl acyl carrier protein (ACP) reductase (InhA) is an important enzyme for Mycobacterium tuberculosis survival. In this study, we report the synthesis of isatin derivatives that could treat TB through inhibition of this enzyme. Compound 4l showed IC

Identifiants

DOI: 10.1016/j.bioorg.2023.106591 PMID: 37201321
pubmed: 37201321
pii: S0045-2068(23)00252-3
doi: 10.1016/j.bioorg.2023.106591
pii:
doi:

Substances chimiques

Acyl Carrier Protein 0
Isatin 82X95S7M06
Oxidoreductases EC 1.-
Antitubercular Agents 0
Pyrimidines 0
Bacterial Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106591

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Abdalrahman Khalifa (A)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt; Department of Chemistry, Prairie View A&M University, Prairie View, TX 77446, USA.

Amira Khalil (A)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt.

Marwa M Abdel-Aziz (MM)

The Regional Center for Mycology & Biotechnology, Al-Azhar University, Cairo, Egypt.

Amgad Albohy (A)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt. Electronic address: amgad.albohy@bue.edu.eg.

Samy Mohamady (S)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo 11837, Egypt. Electronic address: samy.mohamady@bue.edu.eg.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéine ACP › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Isatine › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Isatin-pyrimidine hybrid derivatives as enoyl...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Isatin-pyrimidine hybrid derivatives as enoyl...