Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
12
12
2022
accepted:
05
05
2023
revised:
02
05
2023
pmc-release:
01
11
2024
medline:
23
10
2023
pubmed:
20
5
2023
entrez:
19
5
2023
Statut:
ppublish
Résumé
Impulsive choice has enduring trait-like characteristics and is defined by preference for small immediate rewards over larger delayed ones. Importantly, it is a determining factor in the development and persistence of substance use disorder (SUD). Emerging evidence from human and animal studies suggests frontal cortical regions exert influence over striatal reward processing areas during decision-making in impulsive choice or delay discounting (DD) tasks. The goal of this study was to examine how these circuits are involved in decision-making in animals with defined trait impulsivity. To this end, we trained adolescent male rats to stable behavior on a DD procedure and then re-trained them in adulthood to assess trait-like, conserved impulsive choice across development. We then used chemogenetic tools to selectively and reversibly target corticostriatal projections during performance of the DD task. The prelimbic region of the medial prefrontal cortex (mPFC) was injected with a viral vector expressing inhibitory designer receptors exclusively activated by designer drugs (Gi-DREADD), and then mPFC projections to the nucleus accumbens core (NAc) were selectively suppressed by intra-NAc administration of the Gi-DREADD actuator clozapine-n-oxide (CNO). Inactivation of the mPFC-NAc projection elicited a robust increase in impulsive choice in rats with lower vs. higher baseline impulsivity. This demonstrates a fundamental role for mPFC afferents to the NAc during choice impulsivity and suggests that maladaptive hypofrontality may underlie decreased executive control in animals with higher levels of choice impulsivity. Results such as these may have important implications for the pathophysiology and treatment of impulse control, SUDs, and related psychiatric disorders.
Identifiants
pubmed: 37208501
doi: 10.1038/s41386-023-01604-5
pii: 10.1038/s41386-023-01604-5
pmc: PMC10579332
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1821-1831Subventions
Organisme : NIAAA NIH HHS
ID : F31 AA024683
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA047419
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA043967
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA039690
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042595
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA022340
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.
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