Screening, characterization, and determination of suspected additives bimatoprost and latanoprost in cosmetics using NMR and LC-MS methods.
Bimatoprost
Cosmetics
Eyelash serum
LC–MS
Latanoprost
NMR
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
04
03
2023
accepted:
10
05
2023
revised:
07
05
2023
medline:
26
6
2023
pubmed:
23
5
2023
entrez:
23
5
2023
Statut:
ppublish
Résumé
Recently, many new types of cosmetic illegal additives have been screened in the market. Most of the new additives were new drugs or analogues with very similar structures to other prohibited additives, which were difficult to be identified by liquid chromatography-mass spectrometry (LC-MS) only. Therefore, a new strategy is proposed, which is chromatographic separation combined with nuclear magnetic resonance spectroscopy (NMR) structural identification. The suspected samples were screened by ultra-high-performance liquid chromatography tandem high-resolution mass spectrometry (UPLC-Q-TOF-MS), followed by purification and extraction through silica-gel column chromatography and preparative high-performance liquid chromatography (HPLC). Finally, the extracts were identified unambiguously by NMR as bimatoprost and latanoprost, which were identified to be new cosmetic illegal additives in eyelash serums in China. Meanwhile, bimatoprost and latanoprost were quantified by high-performance liquid chromatography tandem triple quadrupole mass spectrum (HPLC-QQQ-MS/MS). The quantitative method demonstrated good linearity in the range of approximately 0.25-50 ng/mL (R
Identifiants
pubmed: 37219580
doi: 10.1007/s00216-023-04744-1
pii: 10.1007/s00216-023-04744-1
doi:
Substances chimiques
Latanoprost
6Z5B6HVF6O
Bimatoprost
QXS94885MZ
Cosmetics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3549-3558Informations de copyright
© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
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