Cysteine tRNA acts as a stop codon readthrough-inducing tRNA in the human HEK293T cell line.
cysteine tRNA
near-cognate tRNA
readthrough-inducing tRNA
stop codon readthrough
translation
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
17
04
2023
accepted:
12
05
2023
pmc-release:
01
09
2024
medline:
18
8
2023
pubmed:
24
5
2023
entrez:
23
5
2023
Statut:
ppublish
Résumé
Under certain circumstances, any of the three termination codons can be read through by a near-cognate tRNA; i.e., a tRNA whose two out of three anticodon nucleotides base pair with those of the stop codon. Unless programed to synthetize C-terminally extended protein variants with expanded physiological roles, readthrough represents an undesirable translational error. On the other side of a coin, a significant number of human genetic diseases is associated with the introduction of nonsense mutations (premature termination codons [PTCs]) into coding sequences, where stopping is not desirable. Here, the tRNA's ability to induce readthrough opens up the intriguing possibility of mitigating the deleterious effects of PTCs on human health. In yeast, the UGA and UAR stop codons were described to be read through by four readthrough-inducing rti-tRNAs-tRNA
Identifiants
pubmed: 37221013
pii: rna.079688.123
doi: 10.1261/rna.079688.123
pmc: PMC10573299
doi:
Substances chimiques
Codon, Terminator
0
Cysteine
K848JZ4886
RNA, Transfer, Cys
0
RNA, Transfer, Trp
0
RNA, Transfer, Tyr
0
RNA, Transfer
9014-25-9
Anticodon
0
Codon, Nonsense
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1379-1387Informations de copyright
© 2023 Valášek et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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