Acute respiratory failure-related excess mortality in pediatric sepsis.


Journal

Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353

Informations de publication

Date de publication:
11 2023
Historique:
medline: 23 10 2023
pubmed: 25 5 2023
entrez: 24 5 2023
Statut: ppublish

Résumé

Excess mortality risk imparted by acute respiratory failure in children is unknown. We determined excess mortality risk associated with mechanically ventilated acute respiratory failure in pediatric sepsis. Novel ICD10-based algorithms were derived and validated to identify a surrogate for acute respiratory distress syndrome to calculate excess mortality risk. Algorithm-identified ARDS was identified with specificity of 96.7% (CI 93.0 - 98.9) and sensitivity of 70.5% (CI 44.0 - 89.7). Excess risk of mortality for ARDS was 24.4% (CI 22.9 - 26.2). Development of ARDS requiring mechanical ventilation imparts modest excess risk of mortality in septic children.

Identifiants

pubmed: 37225415
pii: thorax-2022-219961
doi: 10.1136/thorax-2022-219961
pmc: PMC10953703
mid: NIHMS1972330
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1135-1137

Subventions

Organisme : NHLBI NIH HHS
ID : K23 HL153759
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD060550
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL115354
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM112596
Pays : United States

Informations de copyright

© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Références

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Auteurs

Garrett Keim (G)

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA keimg@chop.edu.
Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Leonard Davis Institute of Health Economics, Philadelphia, Pennsylvania, USA.

Andrew G Percy (AG)

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Adam S Himebauch (AS)

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Jesse Y Hsu (JY)

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Jason D Christie (JD)

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Nadir Yehya (N)

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Leonard Davis Institute of Health Economics, Philadelphia, Pennsylvania, USA.

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