Exercise metabolism and adaptation in skeletal muscle.
Journal
Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
accepted:
30
03
2023
pmc-release:
01
09
2024
medline:
23
8
2023
pubmed:
25
5
2023
entrez:
24
5
2023
Statut:
ppublish
Résumé
Viewing metabolism through the lens of exercise biology has proven an accessible and practical strategy to gain new insights into local and systemic metabolic regulation. Recent methodological developments have advanced understanding of the central role of skeletal muscle in many exercise-associated health benefits and have uncovered the molecular underpinnings driving adaptive responses to training regimens. In this Review, we provide a contemporary view of the metabolic flexibility and functional plasticity of skeletal muscle in response to exercise. First, we provide background on the macrostructure and ultrastructure of skeletal muscle fibres, highlighting the current understanding of sarcomeric networks and mitochondrial subpopulations. Next, we discuss acute exercise skeletal muscle metabolism and the signalling, transcriptional and epigenetic regulation of adaptations to exercise training. We address knowledge gaps throughout and propose future directions for the field. This Review contextualizes recent research of skeletal muscle exercise metabolism, framing further advances and translation into practice.
Identifiants
pubmed: 37225892
doi: 10.1038/s41580-023-00606-x
pii: 10.1038/s41580-023-00606-x
pmc: PMC10527431
mid: NIHMS1908393
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
607-632Subventions
Organisme : NIA NIH HHS
ID : R00 AG063994
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
Références
PeerJ. 2022 Sep 30;10:e14142
pubmed: 36199287
Skelet Muscle. 2021 Nov 2;11(1):24
pubmed: 34727990
Sci Adv. 2022 Sep 9;8(36):eabo3192
pubmed: 36070371
Acta Physiol (Oxf). 2021 Feb;231(2):e13561
pubmed: 32961628
J Physiol. 2003 Feb 15;547(Pt 1):301-8
pubmed: 12562895
J Struct Biol. 2019 Jul 1;207(1):1-11
pubmed: 30914296
Nat Commun. 2022 May 13;13(1):2661
pubmed: 35562354
J Cell Sci. 2018 Feb 5;131(3):
pubmed: 29361530
Aging Cell. 2022 Jan;21(1):e13528
pubmed: 34904366
Cell Metab. 2022 Feb 1;34(2):329-345.e8
pubmed: 35030324
J Muscle Res Cell Motil. 2000;21(7):691-703
pubmed: 11227796
Science. 1991 May 31;252(5010):1296-300
pubmed: 1925541
Metabolism. 2017 Oct;75:36-44
pubmed: 28927737
EMBO J. 2019 Dec 16;38(24):e102578
pubmed: 31381180
Mol Metab. 2013 Oct 23;3(1):29-41
pubmed: 24567902
Nat Commun. 2020 Jan 10;11(1):174
pubmed: 31924757
Med Sci Sports Exerc. 2016 Nov;48(11):2157-2164
pubmed: 27327032
J Physiol. 2017 May 1;595(9):2839-2847
pubmed: 27696420
BMJ Open Sport Exerc Med. 2015 Aug 21;1(1):e000047
pubmed: 27900134
PLoS One. 2017 Jun 21;12(6):e0178782
pubmed: 28636610
Cell Rep. 2021 Mar 2;34(9):108796
pubmed: 33657380
Sci Signal. 2018 May 15;11(530):
pubmed: 29764991
J Physiol. 2023 Jan 4;:
pubmed: 36597809
J Physiol. 2021 Feb;599(3):863-888
pubmed: 32358865
Nat Med. 2018 Sep;24(9):1360-1371
pubmed: 30061698
Am J Physiol Cell Physiol. 2020 Dec 1;319(6):C1158-C1162
pubmed: 32997515
J Neurol Sci. 1988 Apr;84(2-3):275-94
pubmed: 3379447
Cell Metab. 2021 Nov 2;33(11):2215-2230.e8
pubmed: 34592133
Mol Metab. 2018 Nov;17:71-81
pubmed: 30174227
Cell. 2022 Nov 10;185(23):4448-4464.e17
pubmed: 36272405
Nat Commun. 2021 Dec 3;12(1):7056
pubmed: 34862379
J Appl Physiol (1985). 2022 Jun 1;132(6):1448-1459
pubmed: 35482326
Sports Med. 2020 Oct;50(10):1729-1756
pubmed: 32729096
J Physiol. 2011 Jun 1;589(Pt 11):2871-85
pubmed: 21486810
Front Neurosci. 2015 Feb 27;9:22
pubmed: 25774123
Cell Metab. 2017 May 2;25(5):1186-1193.e4
pubmed: 28467934
Nat Commun. 2021 Oct 27;12(1):6079
pubmed: 34707124
Nat Commun. 2020 Jan 24;11(1):470
pubmed: 31980607
Skelet Muscle. 2015 May 16;5:17
pubmed: 26000164
Diabetologia. 2020 Jun;63(6):1211-1222
pubmed: 32185462
iScience. 2021 Jul 10;24(8):102838
pubmed: 34368654
Nat Metab. 2019 Oct;1(10):975-984
pubmed: 31950102
J Sports Sci Med. 2014 May 01;13(2):349-57
pubmed: 24790489
Acta Physiol Scand. 2005 Jun;184(2):131-9
pubmed: 15916673
J Physiol. 2003 Feb 1;546(Pt 3):677-89
pubmed: 12562996
Nat Rev Endocrinol. 2017 Mar;13(3):133-148
pubmed: 27739515
J Appl Physiol (1985). 1993 Aug;75(2):712-9
pubmed: 8226473
J Physiol. 2022 Nov;600(21):4713-4730
pubmed: 36030498
Hum Genomics. 2022 Jul 22;16(1):24
pubmed: 35869513
Function (Oxf). 2020;1(1):zqaa009
pubmed: 32864621
BMC Genomics. 2022 Jul 17;23(1):519
pubmed: 35842589
PNAS Nexus. 2022 Aug 26;1(4):pgac173
pubmed: 36714847
Dev Cell. 2023 Feb 27;58(4):289-305.e6
pubmed: 36800997
Mol Endocrinol. 2016 Jun;30(6):660-76
pubmed: 27144290
Med Sci Sports Exerc. 2020 Feb;52(2):466-473
pubmed: 31479001
FEBS Lett. 2009 Jul 7;583(13):2294-300
pubmed: 19527715
Sports Med. 2022 Nov;52(11):2569-2578
pubmed: 35460513
FASEB J. 2023 Jan;37(1):e22686
pubmed: 36468768
PLoS One. 2012;7(4):e35273
pubmed: 22530000
PLoS Biol. 2018 Aug 10;16(8):e2005886
pubmed: 30096135
Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E500-8
pubmed: 16188906
Cell. 2014 Sep 25;159(1):33-45
pubmed: 25259918
Nucleic Acids Res. 2021 Dec 16;49(22):13062-13074
pubmed: 34871442
JCI Insight. 2020 Feb 13;5(3):
pubmed: 31895695
Cold Spring Harb Perspect Med. 2018 Feb 1;8(2):
pubmed: 28432118
J Cell Physiol. 1983 Mar;114(3):346-64
pubmed: 6601109
Cell. 2015 Feb 12;160(4):595-606
pubmed: 25640239
Sci Adv. 2021 Dec 17;7(51):eabl4988
pubmed: 34910515
Am J Physiol Endocrinol Metab. 2015 Dec 1;309(11):E900-14
pubmed: 26419588
FASEB J. 2022 Sep;36(9):e22500
pubmed: 35971745
Obes Rev. 2021 Jul;22 Suppl 4:e13269
pubmed: 33960110
J Biol Chem. 2015 Jan 2;290(1):209-27
pubmed: 25389297
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34465622
Cell Rep. 2015 Mar 3;10(8):1269-79
pubmed: 25732818
J Biol Chem. 2016 Dec 2;291(49):25306-25318
pubmed: 27738103
FASEB J. 2021 Jun;35(6):e21611
pubmed: 33977623
Science. 2017 May 5;356(6337):
pubmed: 28473536
Diabetes. 2017 Jun;66(6):1548-1559
pubmed: 28389470
Med Sci Sports Exerc. 2022 Dec 1;54(12):2073-2086
pubmed: 35868015
J Physiol. 2007 Jul 1;582(Pt 1):393-405
pubmed: 17478525
Cell Metab. 2015 Jul 7;22(1):65-76
pubmed: 26154055
Cell Rep. 2020 Dec 29;33(13):108554
pubmed: 33378671
J Physiol. 2001 Oct 1;536(Pt 1):295-304
pubmed: 11579177
Mol Cell. 2019 Jun 6;74(5):877-890.e6
pubmed: 31023583
Front Physiol. 2021 Sep 13;12:709135
pubmed: 34588991
Sports Med. 2018 May;48(5):1031-1048
pubmed: 29453741
Sports Med. 2022 Oct;52(10):2391-2403
pubmed: 35476184
Exp Physiol. 2022 Apr;107(4):312-325
pubmed: 35137992
Am J Physiol Cell Physiol. 2002 Dec;283(6):C1776-83
pubmed: 12419710
Cell Rep. 2022 Dec 20;41(12):111861
pubmed: 36543136
J Appl Physiol (1985). 2023 Jan 1;134(1):116-129
pubmed: 36454678
Cell Metab. 2019 Jul 2;30(1):92-110.e4
pubmed: 31006592
Nat Commun. 2022 Apr 28;13(1):2324
pubmed: 35484130
J Clin Endocrinol Metab. 2001 Dec;86(12):5755-61
pubmed: 11739435
Int J Exerc Sci. 2016 Apr 1;9(2):230-247
pubmed: 27182424
Nature. 2011 Jun 19;476(7360):336-40
pubmed: 21685888
Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):
pubmed: 34426495
Nat Rev Endocrinol. 2023 May;19(5):272-284
pubmed: 36726017
Nat Aging. 2022 Jul;2(7):601-615
pubmed: 36147777
PLoS One. 2013 Jul 02;8(7):e68743
pubmed: 23844238
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):
pubmed: 34493662
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2978-2986
pubmed: 31988126
Genome Biol. 2022 Aug 9;23(1):170
pubmed: 35945592
J Physiol. 1996 Jun 1;493 ( Pt 2):299-307
pubmed: 8782097
J Biol Chem. 2005 Mar 25;280(12):11948-54
pubmed: 15653672
Diabetes. 2015 Jan;64(1):23-35
pubmed: 25071025
Nat Commun. 2019 Oct 11;10(1):4623
pubmed: 31604916
Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E203-8
pubmed: 11158921
Sci Rep. 2019 Mar 1;9(1):3272
pubmed: 30824849
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70
pubmed: 19433800
Nat Cell Biol. 2017 Oct;19(10):1189-1201
pubmed: 28892082
Cell Metab. 2017 Feb 7;25(2):301-311
pubmed: 27916530
Med Sci Sports Exerc. 2014 Mar;46(3):496-505
pubmed: 24091991
Mol Metab. 2022 Dec;66:101615
pubmed: 36252815
Nat Commun. 2018 Aug 2;9(1):3030
pubmed: 30072727
Mayo Clin Proc. 2015 Nov;90(11):1506-14
pubmed: 26455890
Function (Oxf). 2022 Nov 22;4(1):zqac059
pubmed: 36569816
Am J Physiol Cell Physiol. 2022 Jan 1;322(1):C94-C110
pubmed: 34852208
Am J Physiol. 1982 Jan;242(1):E25-32
pubmed: 7058885
Arch Phys Med Rehabil. 2018 Oct;99(10):2100-2113.e5
pubmed: 29425700
Sports Med. 2022 Aug;52(8):1939-1960
pubmed: 35608815
Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1402-11
pubmed: 26858430
J Appl Physiol (1985). 1999 Sep;87(3):1003-8
pubmed: 10484570
Sports Med. 2015 Oct;45(10):1469-81
pubmed: 26243014
J Gen Physiol. 2022 Sep 5;154(9):
pubmed: 35796670
Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13
pubmed: 20028967
Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E928-E938
pubmed: 27780821
Biochem J. 1980 Jul 15;190(1):107-17
pubmed: 6160850
Scand J Med Sci Sports. 2022 Feb;32(2):402-413
pubmed: 34706104
PLoS Genet. 2014 May 22;10(5):e1004386
pubmed: 24852826
Acta Physiol (Oxf). 2018 Sep;224(1):e13069
pubmed: 29608242
Cell. 2020 May 28;181(5):1112-1130.e16
pubmed: 32470399
Crit Rev Food Sci Nutr. 2020;60(21):3669-3679
pubmed: 31851538
Cell Stem Cell. 2017 Jan 5;20(1):56-69
pubmed: 27840022
Nat Commun. 2020 Oct 9;11(1):5102
pubmed: 33037211
Sci Adv. 2022 Jul 29;8(30):eabm7355
pubmed: 35905178
Mayo Clin Proc. 2016 Sep;91(9):1183-8
pubmed: 27444976
Nature. 2022 Jun;606(7915):785-790
pubmed: 35705806
J Appl Physiol (1985). 2000 Jul;89(1):81-8
pubmed: 10904038
Eur J Appl Physiol. 2018 Oct;118(10):2097-2110
pubmed: 30006671
Scand J Med Sci Sports. 2023 Feb;33(2):146-159
pubmed: 36314990
J Appl Physiol (1985). 2001 Nov;91(5):1955-61
pubmed: 11641330
Biochem J. 2016 May 1;473(9):1165-78
pubmed: 26936970
Biochem Biophys Res Commun. 2004 Apr 9;316(3):867-71
pubmed: 15033481
Nat Commun. 2021 Jun 9;12(1):3471
pubmed: 34108459
Appetite. 2023 Mar 1;182:106427
pubmed: 36565929
Nature. 2002 Aug 15;418(6899):797-801
pubmed: 12181572
JCI Insight. 2023 Jan 10;8(1):
pubmed: 36413408
Nat Biotechnol. 2022 Apr;40(4):576-584
pubmed: 34857927
Obes Rev. 2018 Sep;19(9):1177-1188
pubmed: 30035381
J Physiol. 2016 Jan 15;594(2):453-68
pubmed: 26548696
Sports Med. 2022 Aug;52(8):1833-1862
pubmed: 35239154
J Appl Physiol (1985). 2006 Mar;100(3):771-9
pubmed: 16322375
J Physiol. 2023 Feb 1;:
pubmed: 36722691
J Physiol. 2003 May 15;549(Pt 1):255-69
pubmed: 12651917
J Lipid Res. 2011 Apr;52(4):699-711
pubmed: 21297178
J Nutr. 2011 Apr 1;141(4):568-73
pubmed: 21289204
PLoS Med. 2021 Sep 15;18(9):e1003757
pubmed: 34525088
BMJ. 2019 Apr 17;365:l1495
pubmed: 30995986
Am J Physiol. 1989 Oct;257(4 Pt 1):E567-72
pubmed: 2529775
J Physiol. 2012 Nov 1;590(21):5475-86
pubmed: 22907058
J Physiol. 2000 Nov 15;529 Pt 1:237-42
pubmed: 11080265
Nat Commun. 2022 Nov 2;13(1):6558
pubmed: 36323665
Elife. 2022 May 31;11:
pubmed: 35638262
Med Sci Sports Exerc. 2005 Jun;37(6):964-72
pubmed: 15947721
Am J Physiol. 1986 Jul;251(1 Pt 1):E65-70
pubmed: 3728665
Science. 2016 Jan 15;351(6270):275-281
pubmed: 26816379
J Mol Biol. 2003 Sep 26;332(4):877-87
pubmed: 12972258
Biochem J. 1989 Oct 15;263(2):453-62
pubmed: 2597117
Sports Med. 2018 Sep;48(9):2091-2102
pubmed: 29923148
Genome Biol. 2003;4(10):R61
pubmed: 14519196
Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1724-32
pubmed: 19812359
J Physiol. 2020 Jan;598(2):303-315
pubmed: 31696935
Biochemistry. 2004 Nov 30;43(47):15073-85
pubmed: 15554715
Mol Cell Biol. 1999 Nov;19(11):7549-57
pubmed: 10523643
J Biol Chem. 2022 Jun;298(6):101926
pubmed: 35413288
Science. 2016 Jan 15;351(6270):271-5
pubmed: 26816378
J Sports Sci. 2017 Jun;35(11):1073-1082
pubmed: 27433992
J Physiol. 2016 Sep 15;594(18):5209-22
pubmed: 27219125
J Appl Physiol (1985). 2021 Jul 1;131(1):158-173
pubmed: 34013752
Antioxidants (Basel). 2021 Mar 30;10(4):
pubmed: 33808211
Mol Cell. 2022 Sep 1;82(17):3270-3283.e9
pubmed: 35973426
FASEB J. 1999 Dec;13(15):2246-56
pubmed: 10593872
Skelet Muscle. 2016 Mar 30;6:12
pubmed: 27486508
J Physiol. 2015 Nov 1;593(21):4765-80
pubmed: 26359931
Front Physiol. 2020 Sep 15;11:567614
pubmed: 33071823
Nature. 2015 Jul 30;523(7562):617-20
pubmed: 26223627
Nature. 2008 Feb 21;451(7181):1008-12
pubmed: 18288196
Skelet Muscle. 2020 Jul 9;10(1):21
pubmed: 32646489
Med Sci Sports Exerc. 2021 Mar 1;53(3):559-573
pubmed: 32890201
Diabetologia. 2023 Mar;66(3):461-471
pubmed: 36316401
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7789-7794
pubmed: 29987027
Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E879-90
pubmed: 25783895
Nat Commun. 2021 Mar 11;12(1):1547
pubmed: 33707436
J Gerontol A Biol Sci Med Sci. 2023 Mar 1;78(3):373-383
pubmed: 35961318
J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):795-810
pubmed: 35187864
J Appl Physiol (1985). 2006 Sep;101(3):721-7
pubmed: 16614353
Commun Biol. 2022 Oct 27;5(1):1141
pubmed: 36302954
Mol Metab. 2015 Sep 25;4(11):823-33
pubmed: 26629406
J Physiol. 2018 Oct;596(19):4789-4801
pubmed: 30095164
Nat Rev Endocrinol. 2022 May;18(5):273-289
pubmed: 35304603
Front Physiol. 2021 Feb 19;12:619447
pubmed: 33679435
J Physiol. 2011 Aug 15;589(Pt 16):3995-4009
pubmed: 21690197
J Sports Sci. 2019 Jun;37(11):1286-1295
pubmed: 30558493
Nat Metab. 2019 Feb;1(2):291-303
pubmed: 31032475
iScience. 2022 Jun 14;25(7):104589
pubmed: 35789856
J Physiol. 2017 Jun 1;595(11):3377-3387
pubmed: 28133739
FASEB J. 2020 Apr;34(4):5906-5916
pubmed: 32141134
Physiol Rep. 2021 Jan;8(24):e14669
pubmed: 33356015
J Physiol. 2009 Dec 15;587(Pt 24):5951-8
pubmed: 19884317
J Electromyogr Kinesiol. 1999 Apr;9(2):87-95
pubmed: 10098709
J Physiol. 2021 Jul;599(13):3363-3384
pubmed: 33913170
Med Sci Sports Exerc. 2022 Jun 1;54(6):953-964
pubmed: 35081094
Diabetes. 2017 Mar;66(3):598-612
pubmed: 27797909
Cell. 2020 Oct 1;183(1):62-75.e17
pubmed: 32946811
Cell Rep Med. 2021 Sep 09;2(9):100396
pubmed: 34622233
J Physiol. 2017 Sep 1;595(17):5781-5795
pubmed: 28639688
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16098-103
pubmed: 21896730
Nature. 2015 Dec 10;528(7581):276-9
pubmed: 26560032
Brain Res. 2010 Sep 2;1350:151-8
pubmed: 20388497
Acta Physiol (Oxf). 2020 Sep;230(1):e13496
pubmed: 32408395
J Strength Cond Res. 2020 May;34(5):1448-1460
pubmed: 32218059
Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E224-E236
pubmed: 31794264
J Hum Kinet. 2022 Feb 10;81:199-210
pubmed: 35291645
Sports Med. 2023 Mar;53(3):649-665
pubmed: 36334240
Aging Cell. 2022 Feb;21(2):e13552
pubmed: 35048491
Med Sci Sports Exerc. 2016 Apr;48(4):663-72
pubmed: 26741119
Cell Metab. 2017 Mar 7;25(3):581-592
pubmed: 28273480
Sports Med Open. 2022 Nov 12;8(1):138
pubmed: 36370207
J Lipid Res. 2012 Dec;53(12):2610-9
pubmed: 23028113
Diabetologia. 2019 Feb;62(2):233-237
pubmed: 30426166
Cell. 2012 Dec 7;151(6):1319-31
pubmed: 23217713
Cell Rep. 2020 Aug 4;32(5):107980
pubmed: 32755574
Cell Metab. 2018 Feb 6;27(2):378-392.e5
pubmed: 29414686
Cell Rep. 2017 Jun 13;19(11):2396-2409
pubmed: 28614723
Sports Med. 2015 Sep;45(9):1285-1294
pubmed: 25946994
J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):1019-1032
pubmed: 36788413
J Cell Sci. 2023 Feb 15;136(4):
pubmed: 36727534
FASEB J. 2020 Jan;34(1):1602-1619
pubmed: 31914620
J Appl Physiol (1985). 1999 Oct;87(4):1483-90
pubmed: 10517782
Sports Med. 2022 Nov;52(11):2691-2712
pubmed: 35809162
J Biol Chem. 2011 Sep 16;286(37):32436-43
pubmed: 21795684
Cell Metab. 2012 Mar 7;15(3):405-11
pubmed: 22405075
Antioxid Redox Signal. 2013 Feb 20;18(6):603-21
pubmed: 23050834
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4228-4237
pubmed: 30782827
Nat Commun. 2022 Feb 24;13(1):1039
pubmed: 35210422
Genome Biol. 2022 Oct 3;23(1):207
pubmed: 36192798
Trends Endocrinol Metab. 2015 Jun;26(6):305-14
pubmed: 25934582
Brain Res. 2011 Aug 29;1409:42-61
pubmed: 21762884
Nat Commun. 2023 Feb 18;14(1):930
pubmed: 36805455
J Physiol. 2020 Dec;598(24):5739-5752
pubmed: 32939754
Metabolites. 2022 May 16;12(5):
pubmed: 35629949
Sci Rep. 2018 Oct 2;8(1):14710
pubmed: 30279494
J Physiol. 2013 Oct 15;591(20):5141-55
pubmed: 23878361
J Appl Physiol (1985). 1994 Jun;76(6):2253-61
pubmed: 7928844
Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):
pubmed: 34031246
J Physiol. 2022 Jul;600(13):3069-3081
pubmed: 35593645
Sports Med. 2018 Aug;48(8):1809-1828
pubmed: 29934848
Eur J Appl Physiol. 2018 Apr;118(4):691-728
pubmed: 29322250
Cell Metab. 2022 Oct 04;34(10):1561-1577.e9
pubmed: 35882232
Int J Mol Sci. 2022 Oct 26;23(21):
pubmed: 36361732
Cell Rep. 2020 Jun 23;31(12):107808
pubmed: 32579934
JAMA Netw Open. 2022 May 2;5(5):e2211623
pubmed: 35544136
Mol Metab. 2021 Jan;43:101110
pubmed: 33137489
Geroscience. 2022 Aug;44(4):1925-1940
pubmed: 35325353
Sci Rep. 2022 Oct 27;12(1):18116
pubmed: 36302792
J Physiol. 2001 Dec 15;537(Pt 3):971-8
pubmed: 11744769
Nat Commun. 2017 Sep 15;8(1):548
pubmed: 28916822
Br J Sports Med. 2022 Aug 11;:
pubmed: 35953241
J Appl Physiol (1985). 2009 May;106(5):1479-86
pubmed: 19196912
Sci Rep. 2017 Jul 10;7(1):5028
pubmed: 28694500
J Appl Physiol (1985). 2023 Mar 1;134(3):581-592
pubmed: 36656983
NPJ Parkinsons Dis. 2022 Oct 31;8(1):146
pubmed: 36316416
J Clin Invest. 1998 Jan 1;101(1):79-85
pubmed: 9421469
J Appl Physiol (1985). 2013 Feb;114(3):371-9
pubmed: 23239872
J Ren Nutr. 2019 Nov;29(6):480-489
pubmed: 31375416
Nat Commun. 2022 Oct 13;13(1):6058
pubmed: 36229433
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84
pubmed: 16980408
Sports Med. 2022 Nov;52(11):2775-2795
pubmed: 35829994
J Appl Physiol (1985). 1996 Jul;81(1):232-7
pubmed: 8828669
J Appl Physiol (1985). 1990 Jan;68(1):193-8
pubmed: 2312459
Nature. 2011 Jun 19;476(7360):341-5
pubmed: 21685886
J Clin Invest. 2006 Jul;116(7):1853-64
pubmed: 16767219
Exerc Sport Sci Rev. 2020 Oct;48(4):188-200
pubmed: 32658040
J Appl Physiol (1985). 2019 Dec 1;127(6):1632-1639
pubmed: 31697594
J Physiol. 2022 Dec;600(23):5005-5026
pubmed: 36268622
Cell Rep. 2017 Apr 18;19(3):487-496
pubmed: 28423313
J Appl Physiol (1985). 1999 Dec;87(6):2244-52
pubmed: 10601174
FASEB J. 2021 Jun;35(6):e21644
pubmed: 34033143
Nat Rev Endocrinol. 2019 Apr;15(4):197-206
pubmed: 30655625
J Physiol. 2002 Apr 1;540(Pt 1):387-95
pubmed: 11927695
Cell Metab. 2023 Jan 3;35(1):200-211.e9
pubmed: 36309010
Sci Adv. 2023 Feb 3;9(5):eadd0455
pubmed: 36735792
J Lipid Res. 2006 Nov;47(11):2392-9
pubmed: 16905768
J Physiol. 1994 Jul 1;478 ( Pt 1):149-55
pubmed: 7965830
Nat Commun. 2018 Nov 30;9(1):5111
pubmed: 30504768
Sports Med. 2022 Mar;52(3):601-612
pubmed: 34757594
J Clin Invest. 2006 Mar;116(3):675-82
pubmed: 16511602
Cell Rep. 2019 Jan 22;26(4):996-1009.e4
pubmed: 30655224
Diabetes. 2019 Jul;68(7):1427-1440
pubmed: 31010958
Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E1032-9
pubmed: 26487008
Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1053-60
pubmed: 20858747
Mol Metab. 2023 Jan;67:101652
pubmed: 36509362
Am J Physiol. 1999 Nov;277(5):E890-900
pubmed: 10567017
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22
pubmed: 17609368
Sports Med Open. 2022 Oct 29;8(1):135
pubmed: 36308622
FASEB J. 2019 Mar;33(3):4021-4034
pubmed: 30509128
Med Sci Sports Exerc. 2015 Sep;47(9):1922-31
pubmed: 25539479
Innovation (Camb). 2023 Jan 05;4(1):100380
pubmed: 36747595
Appl Physiol Nutr Metab. 2022 Apr;47(4):357-368
pubmed: 35015560
J Appl Physiol (1985). 1996 Mar;80(3):1061-4
pubmed: 8964723
Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1271-8
pubmed: 17095651
Nat Metab. 2022 Feb;4(2):170-179
pubmed: 35210610
FASEB J. 2021 Sep;35(9):e21864
pubmed: 34423880
Nat Commun. 2020 Jul 24;11(1):3722
pubmed: 32709902
Am J Physiol. 1997 Jun;272(6 Pt 1):E1065-70
pubmed: 9227453
Cells. 2023 Jan 09;12(2):
pubmed: 36672198
J Cell Sci. 2021 Jul 15;134(14):
pubmed: 34297126
PLoS Genet. 2021 Dec 6;17(12):e1009951
pubmed: 34871319
Sci Rep. 2018 Jan 30;8(1):1898
pubmed: 29382913
J Exp Biol. 2019 Nov 29;222(Pt 23):
pubmed: 31784473
Nat Commun. 2020 Dec 11;11(1):6375
pubmed: 33311457
Nature. 2023 Jan;613(7942):169-178
pubmed: 36544018
J Biol Chem. 2009 Jun 12;284(24):16522-16530
pubmed: 19380575
EMBO J. 2022 Sep 1;41(17):e111650
pubmed: 35899396
Diabetes. 2017 Jun;66(6):1501-1510
pubmed: 28292969
Mol Endocrinol. 2012 Mar;26(3):372-84
pubmed: 22282471
Eur J Appl Physiol. 2022 Aug;122(8):1751-1772
pubmed: 35355125
Nat Commun. 2021 Oct 12;12(1):5948
pubmed: 34642330
Am J Physiol. 1993 Sep;265(3 Pt 1):E380-91
pubmed: 8214047
J Appl Physiol (1985). 1985 Jul;59(1):137-41
pubmed: 4030557
Cell Metab. 2015 Nov 3;22(5):922-35
pubmed: 26437602
Nat Commun. 2021 Jan 12;12(1):304
pubmed: 33436631
J Physiol. 2018 Jan 15;596(2):231-252
pubmed: 28983994
Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C39-C57
pubmed: 36409174
J Physiol. 2016 Dec 15;594(24):7399-7417
pubmed: 27654940
Sports Med Open. 2015 Dec;1(1):7
pubmed: 27747846
J Physiol. 2013 Jul 15;591(14):3625-36
pubmed: 23690562
Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1191-7
pubmed: 16682488
J Cell Physiol. 2016 Sep;231(9):1894-902
pubmed: 26684695
J Clin Endocrinol Metab. 2015 Jun;100(6):2205-13
pubmed: 25867814
Nutr Rev. 2023 Mar 10;81(4):416-427
pubmed: 35984306
Cell. 2013 Sep 26;155(1):160-71
pubmed: 24055366
Epigenetics. 2014 Dec;9(12):1557-69
pubmed: 25484259
Sci Transl Med. 2021 Dec 08;13(623):eabc7367
pubmed: 34878822