Molecular functions of RNA helicases during ribosomal subunit assembly.
DEAH box protein
DExD box protein
RNA helicase
RNP remodelling
ribosome
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
26 07 2023
26 07 2023
Historique:
received:
14
02
2023
accepted:
09
05
2023
medline:
8
9
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
During their biogenesis, the ribosomal subunits undergo numerous structural and compositional changes to achieve their final architecture. RNA helicases are a key driving force of such remodelling events but deciphering their particular functions has long been challenging due to lack of knowledge of their molecular functions and RNA substrates. Advances in the biochemical characterisation of RNA helicase activities together with new insights into RNA helicase binding sites on pre-ribosomes and structural snapshots of pre-ribosomal complexes containing RNA helicases now open the door to a deeper understanding of precisely how different RNA helicases contribute to ribosomal subunit maturation.
Identifiants
pubmed: 37233600
pii: hsz-2023-0135
doi: 10.1515/hsz-2023-0135
doi:
Substances chimiques
RNA Helicases
EC 3.6.4.13
RNA
63231-63-0
RNA, Ribosomal
0
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-789Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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