Metals and the cell surface of Cryptococcus neoformans.

Cryptococcus neoformans / metabolism Copper / metabolism Fungal Proteins / metabolism Cryptococcosis / microbiology Iron / metabolism

Journal

Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056

Informations de publication

Date de publication:
08 2023
Historique:
received: 27 02 2023
revised: 18 04 2023
accepted: 01 05 2023
pmc-release: 01 08 2024
medline: 4 8 2023
pubmed: 1 6 2023
entrez: 31 5 2023
Statut: ppublish

Résumé

Recent studies in pathogenic yeasts reinforce our appreciation of the influence of metal homeostasis on the fungal cell surface. To illustrate this influence, we focus on recent studies on Cryptococcus neoformans, a fungal pathogen with a complex surface of a cell wall with embedded melanin and an attached polysaccharide capsule. Copper and iron are essential yet toxic metals, and current efforts demonstrate the importance of these metals for modulating the surface structure of C. neoformans cells in ways that contribute to fungal-host interactions during disease in vertebrate hosts. In this review, we briefly summarize mechanisms of acquisition and regulation for copper and iron, and then discuss recent insights into the connections between the metals and the cell surface.

Identifiants

DOI: 10.1016/j.mib.2023.102331 PMID: 37257400 PMC: PMC10513164
pubmed: 37257400
pii: S1369-5274(23)00068-1
doi: 10.1016/j.mib.2023.102331
pmc: PMC10513164
mid: NIHMS1931490
pii:
doi:

Substances chimiques

Copper 789U1901C5
Fungal Proteins 0
Iron E1UOL152H7

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102331

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI053721
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Peng Xue (P)

Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Guanggan Hu (G)

Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Won Hee Jung (WH)

Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea.

James W Kronstad (JW)

Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. Electronic address: kronstad@msl.ubc.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Levures › Cryptococcus › Cryptococcus neoformans › Metals and the cell surface of Cryptococcus neoformans.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Metals and the cell surface of Cryptococcus neoformans.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Metals and the cell surface of Cryptococcus neoformans.
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › Cryptococcose › Metals and the cell surface of Cryptococcus neoformans.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Metals and the cell surface of Cryptococcus neoformans.