Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?
Biomarker
Brain dysfunction
Delirium
Encephalopathy
Neurofilament light chain
SAE
Sepsis
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
31 05 2023
31 05 2023
Historique:
received:
17
03
2023
accepted:
18
05
2023
medline:
2
6
2023
pubmed:
1
6
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result in increased mortality, extended length of hospital stay, and long-term cognitive dysfunction. The diagnosis of SAE is based on clinical assessments, but a valid biomarker to identify and confirm SAE and to assess SAE severity is missing. Several blood-based biomarkers indicating neuronal injury have been evaluated in sepsis and their potential role as early diagnosis and prognostic markers has been studied. Among those, the neuroaxonal injury marker neurofilament light chain (NfL) was identified to potentially serve as a prognostic biomarker for SAE and to predict long-term cognitive impairment. In this review, we summarize the current knowledge of biomarkers, especially NfL, in SAE and discuss a possible future clinical application considering existing limitations.
Identifiants
pubmed: 37259091
doi: 10.1186/s13054-023-04497-4
pii: 10.1186/s13054-023-04497-4
pmc: PMC10230136
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
214Informations de copyright
© 2023. The Author(s).
Références
Crit Care. 2020 May 19;24(1):239
pubmed: 32430052
Intensive Care Med. 2007 Jun;33(6):941-50
pubmed: 17410344
Neurology. 2023 Jan 31;100(5):e473-e484
pubmed: 36261295
Sci Rep. 2021 May 26;11(1):11034
pubmed: 34040118
Anesthesiology. 2022 Sep 1;137(3):303-314
pubmed: 35984933
Mol Med. 2012 Sep 07;18:930-7
pubmed: 22634723
JAMA Neurol. 2019 Feb 1;76(2):187-193
pubmed: 30419087
Aging (Albany NY). 2021 Dec 18;13(24):25729-25738
pubmed: 34923481
JAMA. 2010 Oct 27;304(16):1787-94
pubmed: 20978258
Ann Neurol. 2021 Jul;90(1):174-175
pubmed: 34036618
Crit Care. 2021 Mar 17;25(1):108
pubmed: 33731201
Am J Respir Crit Care Med. 2014 Jul 1;190(1):62-9
pubmed: 24872085
Crit Care Med. 2006 Jul;34(7):1967-74
pubmed: 16607230
Am J Respir Crit Care Med. 2014 May 1;189(9):1065-74
pubmed: 24456535
JAMA. 1987 Oct 2;258(13):1789-92
pubmed: 3625989
PLoS One. 2019 Jan 24;14(1):e0211184
pubmed: 30677080
J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):68-74
pubmed: 34417339
Crit Care Med. 2019 Nov;47(11):1531-1538
pubmed: 31389836
Lancet Neurol. 2022 Mar;21(3):246-257
pubmed: 35182510
J Neuroimmunol. 2017 Feb 15;303:90-98
pubmed: 28087076
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Crit Care Med. 2020 May;48(5):e436-e437
pubmed: 32301790
BMJ Open. 2021 Mar 17;11(3):e043352
pubmed: 33737430
Intensive Care Med. 2017 Aug;43(8):1075-1084
pubmed: 28466149
Brain Commun. 2022 Jul 26;4(4):fcac195
pubmed: 35938070
EBioMedicine. 2022 Jun;80:104043
pubmed: 35533500
BMC Cancer. 2022 Mar 26;22(1):330
pubmed: 35346107
Nat Commun. 2020 Feb 10;11(1):812
pubmed: 32041951
JAMA Neurol. 2016 Jan;73(1):60-7
pubmed: 26524180
J Neurol. 2019 Jul;266(7):1643-1648
pubmed: 30944980
JAMA Pediatr. 2018 Nov 1;172(11):1092-1095
pubmed: 30264151
Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4):
pubmed: 28373358
Front Aging Neurosci. 2021 Feb 10;13:637703
pubmed: 33643027
J Neurochem. 2022 Nov;163(3):179-219
pubmed: 35950263
Curr Opin Cell Biol. 2015 Feb;32:92-101
pubmed: 25635910
Lancet Neurol. 2022 Jan;21(1):66-77
pubmed: 34838239
Can J Infect Dis Med Microbiol. 2019 Jul 17;2019:1876174
pubmed: 31396296
J Intensive Care Med. 2021 Mar;36(3):262-270
pubmed: 31916880
Brain Pathol. 2004 Jan;14(1):21-33
pubmed: 14997934
Acta Anaesthesiol Scand. 2019 Jan;63(1):69-73
pubmed: 30079511
Crit Care. 2012 Jul 03;16(4):R115
pubmed: 22759376
Crit Care. 2010;14(3):R81
pubmed: 20444270
J Cell Sci. 2012 Jul 15;125(Pt 14):3257-63
pubmed: 22956720
JAMA. 2001 Dec 5;286(21):2703-10
pubmed: 11730446
JAMA. 2018 Jan 2;319(1):62-75
pubmed: 29297082
Clin Chem Lab Med. 2016 Oct 1;54(10):1655-61
pubmed: 27071153
J Neuroinflammation. 2021 Sep 12;18(1):195
pubmed: 34511123
J Neuroinflammation. 2008 Aug 29;5:37
pubmed: 18759972
Prog Neurobiol. 2010 Mar;90(3):327-62
pubmed: 19879917
Intensive Care Med. 2001 May;27(5):859-64
pubmed: 11430542
Crit Care Med. 2010 Jul;38(7):1513-20
pubmed: 20473145
Anaesthesist. 2021 Feb;70(2):112-120
pubmed: 32970160
J Neurol. 2021 Oct;268(10):3574-3583
pubmed: 33743046
Am J Respir Crit Care Med. 2021 Mar 15;203(6):699-706
pubmed: 33030981
J Clin Med. 2020 Mar 05;9(3):
pubmed: 32150970
Brain Commun. 2022 Jul 04;4(4):fcac174
pubmed: 35865350
Crit Care Med. 2009 Oct;37(10 Suppl):S331-6
pubmed: 20046118
Lab Anim Sci. 1990 Mar;40(2):202-3
pubmed: 2157104
Annu Rev Med. 2016;67:497-513
pubmed: 26768245
Nat Rev Dis Primers. 2020 Nov 12;6(1):90
pubmed: 33184265
Curr Opin Neurol. 2021 Apr 1;34(2):266-274
pubmed: 33470669
Lancet Respir Med. 2018 Mar;6(3):213-222
pubmed: 29508705
Crit Care. 2014 May 23;18(3):R106
pubmed: 24886875
Sci Transl Med. 2021 Jul 14;13(602):
pubmed: 34131052
J Neurochem. 2019 Jan;148(2):168-187
pubmed: 30144068
Neuropathol Appl Neurobiol. 2019 Apr;45(3):278-290
pubmed: 29804289
Int J Neurosci. 2023 Mar;133(3):327-333
pubmed: 33851572
JCI Insight. 2018 May 3;3(9):
pubmed: 29720578
N Engl J Med. 2013 Oct 3;369(14):1306-16
pubmed: 24088092
Adv Med. 2014;2014:762320
pubmed: 26556425
Crit Care. 2017 Oct 23;21(1):262
pubmed: 29058589
Neurochem Res. 2014 Jul;39(7):1263-9
pubmed: 24760429
Lancet. 2018 Jul 7;392(10141):75-87
pubmed: 29937192
Brain. 2023 Feb 13;146(2):421-437
pubmed: 36083979
Brain Behav Immun. 2020 Oct;89:656-667
pubmed: 32592865
Can J Neurol Sci. 1985 Nov;12(4):303-7
pubmed: 4084865
Lancet Neurol. 2017 Aug;16(8):661-676
pubmed: 28721928
Crit Care Med. 2012 Feb;40(2):502-9
pubmed: 21946660
Ann Clin Transl Neurol. 2022 May;9(5):622-632
pubmed: 35313387
Lancet Respir Med. 2014 May;2(5):369-79
pubmed: 24815803
Nat Rev Neurol. 2018 Oct;14(10):577-589
pubmed: 30171200
J Neurosci. 2018 Mar 21;38(12):3060-3080
pubmed: 29487124
Aust Crit Care. 2018 Jul;31(4):204-211
pubmed: 28736089
Lancet. 2020 Jan 18;395(10219):200-211
pubmed: 31954465
Clin Chem Lab Med. 2021 Mar 23;60(4):569-575
pubmed: 33759425
Brain. 2020 Jul 1;143(7):1975-1998
pubmed: 32408345
Intensive Care Med. 2021 Oct;47(10):1089-1103
pubmed: 34401939
Neurosci Lett. 2019 Jan 23;692:167-173
pubmed: 30423400
Ann Clin Transl Neurol. 2023 Feb;10(2):204-212
pubmed: 36479924
Arch Surg. 2011 Mar;146(3):295-300
pubmed: 21422360
J Natl Cancer Inst. 2001 Jul 18;93(14):1054-61
pubmed: 11459866
J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):62-9
pubmed: 23134661
Lancet. 2003 Nov 29;362(9398):1799-805
pubmed: 14654318
Clin Chem Lab Med. 2023 Mar 07;61(7):1140-1149
pubmed: 36880940
Crit Care Med. 2020 Mar;48(3):353-361
pubmed: 31770149
Sci Rep. 2020 May 7;10(1):7718
pubmed: 32382007
J Pain Symptom Manage. 2005 Apr;29(4):368-75
pubmed: 15857740
Ann Neurol. 2021 Mar;89(3):610-616
pubmed: 33377539
Neurology. 2017 Nov 28;89(22):2230-2237
pubmed: 29079686
J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):870-881
pubmed: 30967444
Crit Care Explor. 2020 Oct 02;2(10):e0238
pubmed: 33063038
JAMA. 2017 Feb 7;317(5):530-531
pubmed: 28114505
J Neurol. 2021 Dec;268(12):4436-4442
pubmed: 33973106
Br J Anaesth. 2007 Oct;99(4):518-21
pubmed: 17650519
Ann Neurol. 2022 Oct;92(4):688-698
pubmed: 35730070
J Crit Care. 2016 Dec;36:18-23
pubmed: 27546742
Crit Care. 2014 Jan 20;18(1):R18
pubmed: 24443841
J Neurochem. 2021 Nov;159(3):525-542
pubmed: 34379806
Crit Care. 2020 Jul 31;24(1):476
pubmed: 32736572
Proc Natl Acad Sci U S A. 1987 May;84(10):3472-6
pubmed: 3472217
Brain Behav Immun. 2013 Mar;29:28-38
pubmed: 23108061
Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72
pubmed: 26414292
Pharmacoeconomics. 2015 Sep;33(9):925-37
pubmed: 25935211
Crit Care Med. 2012 Jul;40(7):2022-32
pubmed: 22710202
Nat Rev Neurol. 2012 Oct;8(10):557-66
pubmed: 22986430
J Crit Care. 2019 Aug;52:172-179
pubmed: 31078998