Efficient Secretory Production of δ-Tocotrienol by Combining Pathway Modularization and Transportation Engineering.

Vitamin E Tocotrienols Cholesterol
Saccharomyces cerevisiae cyclodextrin pathway engineering secretory production δ-tocotrienol

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
14 Jun 2023
Historique:
medline: 15 6 2023
pubmed: 1 6 2023
entrez: 1 6 2023
Statut: ppublish

Résumé

The vitamin E component δ-tocotrienol has shown impressive activities in radioprotection, neuroprotection, and cholesterol reduction. Its production is limited by the low content in plants and difficulty in separation from other tocotrienols. Fermentative production using a microbial cell factory that exclusively produces and secretes δ-tocotrienol is a promising alternative approach. Assembly of the δ-tocotrienol synthetic pathway in

Identifiants

DOI: 10.1021/acs.jafc.3c01743 PMID: 37262183
pubmed: 37262183
doi: 10.1021/acs.jafc.3c01743
doi:

Substances chimiques

tocotrienol, delta 1SRB74OWSI
Vitamin E 1406-18-4
Tocotrienols 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9020-9030

Auteurs

Xue Jiao (X)

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Qi Bian (Q)

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China.

Taotao Feng (T)

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Xiaomei Lyu (X)

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
ORCID: 0000-0002-9008-6121

Hongwei Yu (H)

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
ORCID: 0000-0002-9144-4496

Lidan Ye (L)

Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China.
ORCID: 0000-0002-6248-8457

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Efficient Secretory Production of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocotriénols › Efficient Secretory Production of...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Efficient Secretory Production of...