Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand.

RNA, Bacterial / chemistry Riboswitch Ligands Cryoelectron Microscopy Escherichia coli Proteins / metabolism DNA-Directed RNA Polymerases / metabolism Transcription, Genetic RNA Folding Bacteria / metabolism Nucleic Acid Conformation

Journal

Nature structural & molecular biology
ISSN: 1545-9985
Titre abrégé: Nat Struct Mol Biol
Pays: United States
ID NLM: 101186374

Informations de publication

Date de publication:
07 2023
Historique:
received: 16 11 2021
accepted: 20 04 2023
pmc-release: 01 07 2024
medline: 19 7 2023
pubmed: 2 6 2023
entrez: 1 6 2023
Statut: ppublish

Résumé

Folding of nascent transcripts can be modulated by the RNA polymerase (RNAP) that carries out their transcription, and vice versa. A pause of RNAP during transcription of a preQ

Identifiants

DOI: 10.1038/s41594-023-01002-x PMID: 37264140 PMC: PMC10523900
pubmed: 37264140
doi: 10.1038/s41594-023-01002-x
pii: 10.1038/s41594-023-01002-x
pmc: PMC10523900
mid: NIHMS1892403
doi:

Substances chimiques

RNA, Bacterial 0
Riboswitch 0
Ligands 0
Escherichia coli Proteins 0
DNA-Directed RNA Polymerases EC 2.7.7.6

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

902-913

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118524
Pays : United States
Organisme : NIH HHS
ID : S10 OD030275
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031922
Pays : United States
Organisme : NIH HHS
ID : S10 OD020011
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131922
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Adrien Chauvier (A)

Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0003-4473-6194

Jason C Porta (JC)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Indrajit Deb (I)

Biophysics Program, University of Michigan, Ann Arbor, MI, USA.
Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.

Emily Ellinger (E)

Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Katarina Meze (K)

Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0003-0849-9304

Aaron T Frank (AT)

Biophysics Program, University of Michigan, Ann Arbor, MI, USA.
Arrakis Therapeutics, Waltham, MA, USA.

Melanie D Ohi (MD)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. mohi@umich.edu.
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. mohi@umich.edu.
ORCID: 0000-0003-1750-4793

Nils G Walter (NG)

Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. nwalter@umich.edu.
ORCID: 0000-0002-7301-1275

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN bactérien › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Séquences régulatrices de l'acide ribonucléique › Riborégulateur › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Pliage de l'ARN › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Bactéries › Structural basis for control of bacterial RNA...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Structural basis for control of bacterial RNA...