Comparison of Methemoglobin, Deoxyhemoglobin, and Ferrous Nitrosyl Hemoglobin as Potential MRI Contrast Agents.
Angiography
Blood
Hemoglobin
Imaging
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
13
10
2022
accepted:
30
04
2023
pmc-release:
01
09
2024
medline:
9
8
2023
pubmed:
4
6
2023
entrez:
3
6
2023
Statut:
ppublish
Résumé
Gadolinium-based contrast agents (GBCAs) are in widespread use to enhance magnetic resonance imaging for evaluating vascular pathology. However, safety concerns and limitations regarding the use of GBCAs has led to an increased interest in alternative contrast agents. Previously, methemoglobin (metHb) and oxygen-free hemoglobin (HHb) have been shown to increase the T1-weighted signal intensity of blood, which is associated with a decrease in the T1 parameter and an enhanced contrast of the image. Thus, a lower T1 value compared to the baseline value is favorable for imaging. However, it is unknown as to whether metHb or HHb would be a stronger and more appropriate contrast agent and to what extent the T1-weighted signal is affected by concentration. This study evaluated T1-weighted images of blood samples over a range of metHb and HHb concentrations, as well as ferrous nitrosyl hemoglobin (Hb
Identifiants
pubmed: 37270456
doi: 10.1007/s10439-023-03226-w
pii: 10.1007/s10439-023-03226-w
pmc: PMC10529426
mid: NIHMS1922627
doi:
Substances chimiques
deoxyhemoglobin
9008-02-0
Methemoglobin
9008-37-1
nitrosyl hemoglobin
0
Contrast Media
0
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2013-2020Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR002538
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR002538
Pays : United States
Informations de copyright
© 2023. The Author(s) under exclusive licence to Biomedical Engineering Society.
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