Metabolic Engineering of

Cellulose / metabolism Metabolic Engineering / methods Xylose / metabolism Fermentation Saccharum / metabolism Transcription Factors / metabolism
Candida glycerinogenes geraniol lignocellulosic biomass metabolic engineering xylose metabolism

Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
16 06 2023
Historique:
medline: 19 6 2023
pubmed: 5 6 2023
entrez: 5 6 2023
Statut: ppublish

Résumé

Geraniol is a class of natural products that are widely used in the aroma industry due to their unique aroma. Here, to achieve the synthesis of geraniol and alleviate the intense competition from the yeast ergosterol pathway, a transcription factor-mediated ergosterol feedback system was developed in this study to autonomously regulate ergosterol metabolism and redirect carbon flux to geraniol synthesis. In addition, the modification of ergosterol-responsive promoters, the optimization of transcription factor expression intensity, and stepwise metabolic engineering resulted in a geraniol titer of 531.7 mg L

Identifiants

DOI: 10.1021/acssynbio.3c00195 PMID: 37271978
pubmed: 37271978
doi: 10.1021/acssynbio.3c00195
doi:

Substances chimiques

Cellulose 9004-34-6
geraniol L837108USY
Xylose A1TA934AKO
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1836-1844

Auteurs

Cui Zhao (C)

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
ORCID: 0000-0001-9594-9590

Xi-Hui Wang (XH)

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
ORCID: 0000-0001-6754-8044

Xin-Yao Lu (XY)

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China.

Hong Zong (H)

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China.

Bin Zhuge (B)

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China.

Articles similaires

Expression interplay of genes coding for calcium-binding proteins and transcription factors during the osmotic phase provides insights on salt stress response mechanisms in bread wheat.

Diana Duarte-Delgado, Inci Vogt, Said Dadshani et al.
1.00
Triticum Transcription Factors Gene Expression Regulation, Plant Plant Proteins Salt Stress

Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors.

Yingyun Yang, Dahan Wen, Feng Lin et al.
1.00
Animals Humans Mice Neoplasms Tumor Microenvironment

Saccharomyces cerevisiae whole cell biotransformation for the production of aldehyde flavors and fragrances.

Nazreen V M Abdul Muthaliff, Yao Zong Ng, Wei Mei Guo et al.
1.00
Saccharomyces cerevisiae Aldehydes Biotransformation Flavoring Agents Lipoxygenase

Bioefficiency of microencapsulated hemp leaf phytonutrient-based extracts to enhance in vitro rumen fermentation and mitigate methane production.

Srisan Phupaboon, Maharach Matra, Ronnachai Prommachart et al.
1.00
Animals Rumen Methane Fermentation Cannabis

Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Metabolic Engineering of
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Metabolic Engineering of
questionsmedicales.fr › Glucides › Sucres › Oses › Pentoses › Xylose › Metabolic Engineering of
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Fermentation › Metabolic Engineering of
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Poaceae › Saccharum › Metabolic Engineering of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Metabolic Engineering of