Human immunodeficiency virus coinfection differentially impacts hepatitis B virus viral markers based on hepatitis Be antigen status in patients with suppressed viremia.
Adult
Humans
Hepatitis B virus
/ genetics
Hepatitis B e Antigens
Hepatitis B, Chronic
/ complications
Hepatitis B Surface Antigens
Coinfection
/ drug therapy
Cohort Studies
Viremia
/ drug therapy
HIV
DNA, Viral
/ genetics
Hepatitis B
Hepatitis B Core Antigens
Biomarkers
RNA
Antiviral Agents
/ therapeutic use
HIV Infections
/ complications
HBV
HBV RNA
HBcrAg
HIV
serum biomarkers
Journal
Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
13
04
2023
received:
10
02
2023
accepted:
24
05
2023
pmc-release:
01
08
2024
medline:
29
9
2023
pubmed:
6
6
2023
entrez:
6
6
2023
Statut:
ppublish
Résumé
Hepatitis B virus (HBV) RNA and hepatitis B core-related antigen (HBcrAg), reflecting transcriptional activity of covalently closed circular DNA, are gaining traction as important markers to assess viral activity. Whether their expression differs under viral suppression by HIV co-infection status is unknown. Among adults with chronic HBV on antiviral therapy, we sought to determine if the expression of HBV markers (specialized and well-established) differs between HBV-HIV co-infection vs. HBV mono-infection. We compared HBV marker levels among 105 participants in the Hepatitis B Research Network (HBRN) HBV-HIV Ancillary Study and 105 participants in the HBRN mono-infected Cohort Study, matched for HBeAg status and HBV DNA suppression on therapy. Among HBeAg+ participants (N = 58 per group), after adjusting for age, sex, race, ALT and HBV DNA, viral markers were higher (p < .05) in the HBV-HIV versus the HBV-only sample (HBeAg: 1.05 vs. 0.51 log
Identifiants
pubmed: 37278302
doi: 10.1111/jvh.13857
pmc: PMC10524380
mid: NIHMS1904853
doi:
Substances chimiques
Hepatitis B e Antigens
0
Hepatitis B Surface Antigens
0
DNA, Viral
0
Hepatitis B Core Antigens
0
Biomarkers
0
RNA
63231-63-0
Antiviral Agents
0
Banques de données
ClinicalTrials.gov
['NCT01263587', 'NCT01924455']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
700-709Subventions
Organisme : NIDA NIH HHS
ID : K24 DA034621
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001111
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK094818
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082923
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082867
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082874
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024986
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082919
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082927
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082872
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082943
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA022523
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK050306
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000040
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082871
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082944
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082864
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082843
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082863
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000004
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082866
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000058
Pays : United States
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
J Med Virol. 2017 Mar;89(3):463-468
pubmed: 27505145
Hepatology. 2018 Dec;68(6):2106-2117
pubmed: 29734472
Am J Gastroenterol. 2019 May;114(5):746-757
pubmed: 30410040
J Gastroenterol. 2013 Oct;48(10):1188-204
pubmed: 23397114
Clin Gastroenterol Hepatol. 2023 Jan;21(1):125-135.e8
pubmed: 34973459
Clin Gastroenterol Hepatol. 2015 Jan;13(1):183-92
pubmed: 25010003
J Gastroenterol. 2017 Jan;52(1):127-128
pubmed: 27665100
Am J Gastroenterol. 2016 Dec;111(12):1788-1795
pubmed: 27644733
PLoS One. 2012;7(7):e36349
pubmed: 22911677
Ann Intern Med. 2002 Jul 2;137(1):1-10
pubmed: 12093239
Hepatology. 2023 Feb 1;77(2):594-605
pubmed: 35770681
Hepatology. 2015 Jan;61(1):66-76
pubmed: 25132147
Hepatology. 2021 Nov;74(5):2395-2409
pubmed: 34133774
J Hepatol. 2016 Oct;65(4):700-710
pubmed: 27245431