Synthesis and Antitumor Activity of Panaxadiol Pyrazole and Isooxazole Derivatives.
antitumor agents
derivatives
ginsenosides
panaxadiol
pyrazole
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
08
04
2023
accepted:
05
06
2023
medline:
24
8
2023
pubmed:
6
6
2023
entrez:
6
6
2023
Statut:
ppublish
Résumé
In this study, we designed and synthesized 19 nitrogen-containing heterocyclic derivatives of panaxadiol (PD). We first reported the antiproliferative activity of these compounds against four different tumor cells. The results of the MTT assay showed that the PD pyrazole derivative (compound 12b) had the best antitumor activity and could significantly inhibit the proliferation of four tested tumor cells. For A549 cells, the IC
Identifiants
pubmed: 37279052
doi: 10.1002/cbdv.202300507
doi:
Substances chimiques
panaxadiol
19666-76-3
Ginsenosides
0
Antineoplastic Agents
0
Pyrazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202300507Subventions
Organisme : Higher Education Discipline Innovation Project
ID : D18012
Organisme : Liaoning (FGW) Engineering Technology Research Center for industrial chromatographic preparation of natural innovative drugs materials
ID : 2017-1007
Informations de copyright
© 2023 Wiley-VHCA AG, Zurich, Switzerland.
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