A plain language summary on the effectiveness of cladribine tablets compared with other oral treatments for multiple sclerosis: results from the MSBase registry.

cladribine tablets dimethyl fumarate (Tecfidera®) fingolimod (Gilenya®) lay summary multiple sclerosis relapses teriflunomide (Aubagio®) treatment options

Journal

Neurodegenerative disease management
ISSN: 1758-2032
Titre abrégé: Neurodegener Dis Manag
Pays: England
ID NLM: 101517977

Informations de publication

Date de publication:
Aug 2023
Historique:
medline: 10 7 2023
pubmed: 8 6 2023
entrez: 8 6 2023
Statut: ppublish

Résumé

Patient registries contain anonymous data from people who share the same medical condition. The MSBase registry contains information from over 80,000 people living with multiple sclerosis (MS) across 41 countries. Using information from the MSBase registry, the GLIMPSE (Generating Learnings In MultiPle SclErosis) study looked at real-life outcomes in 3475 people living with MS who were treated with cladribine tablets (Mavenclad Results showed that people treated with cladribine tablets stayed on treatment for longer than other treatments given by mouth. They also had fewer relapses (also called flare ups of symptoms) than people who received a different oral treatment for their MS. The results provide evidence that, compared with other oral treatments for MS, cladribine tablets are an effective medicine for people living with MS.

Identifiants

pubmed: 37287269
doi: 10.2217/nmt-2023-0005
doi:

Substances chimiques

Cladribine 47M74X9YT5
Immunosuppressive Agents 0
Tablets 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

215-221

Auteurs

Tim Spelman (T)

MSBase Foundation, Melbourne, Australia.

Serkan Ozakbas (S)

Dokuz Eylul University, Izmir, Turkey.

Raed Alroughani (R)

Amiri Hospital, Sharq, Kuwait.

Murat Terzi (M)

Department of Neurology 19 Mayis University, Samsun, Turkey.

Suzanne Hodgkinson (S)

Liverpool Hospital, Sydney, Australia.

Guy Laureys (G)

University Hospital Ghent, Ghent, Belgium.

Tomas Kalincik (T)

MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.
CORe, Department of Medicine, University of Melbourne, Melbourne, Australia.

Anneke Van Der Walt (AV)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.

Bassem Yamout (B)

Neurology Institute, Harley Street Medical Center, Abu Dhabi, United Arab Emirates.
American University of Beirut Medical Center, Beirut, Lebanon.

Jeannette Lechner-Scott (J)

School of Medicine & Public Health, University of Newcastle, Newcastle, Australia.
Department of Neurology, John Hunter Hospital, Hunter New England Health, Newcastle, Australia.

Aysun Soysal (A)

Bakirkoy Education & Research Hospital for Psychiatric & Neurological Diseases, Istanbul, Turkey.

Jens Kuhle (J)

Multiple Sclerosis Centre, Neurology, Departments of Head, Spine & Neuromedicine, Biomedicine & Clinical Research, University Hospital Basel & University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology & Neuroscience (RC2NB), University Hospital & University of Basel, Switzerland.

Jose Luis Sanchez-Menoyo (JL)

Department of Neurology, Galdakao-Usansolo University Hospital, Osakidetza-Basque Health Service, Biocruces-Bizkaia Health Research Institute, Galdakao, Spain.

Yolanda Blanco Morgado (YB)

Center of Neuroimmunology, Service of Neurology, Hospital Clinic de Barcelona, Barcelona, Spain.

Daniele LA Spitaleri (D)

Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italy.

Vincent van Pesch (VV)

Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium.

Dana Horakova (D)

Department of Neurology & Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague & General University Hospital, Prague, Czech Republic.

Radek Ampapa (R)

Nemocnice Jihlava, Jihlava, Czech Republic.

Francesco Patti (F)

Department of Medical & Surgical Sciences & Advanced Technologies, GF Ingrassia, Catania, Italy.

Richard Macdonell (R)

Department of Neurology, Austin Health, Melbourne, Australia.

Abdullah Al-Asmi (A)

Neurology Unit, Department of Medicine, College of Medicine & Health Sciences & Sultan Qaboos University Hospital, SQU, Al Khodh, Oman.

Oliver Gerlach (O)

Academic MS Center Zuyderland, Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.
School for Mental Health & Neuroscience, Maastricht University, Maastricht, The Netherlands.

Jiwon Oh (J)

Division of Neurology, St Michael's Hospital, University of Toronto, Toronto, Canada.

Ayse Altintas (A)

Koc University School of Medicine & Koc University Research Center for Translational Medicine (KUTTAM) Istanbul, Turkey.

Namita Tundia (N)

EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA.

Schiffon L Wong (SL)

EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA.

Helmut Butzkueven (H)

MSBase Foundation, Melbourne, Australia.
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.

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Classifications MeSH