Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA.

Emulsions / chemistry DNA / chemistry Oligonucleotides Cholesterol

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
27 Jun 2023
Historique:
medline: 29 6 2023
pubmed: 9 6 2023
entrez: 9 6 2023
Statut: epublish

Résumé

Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.

Identifiants

DOI: 10.1039/d3cc00888f PMID: 37294173
pubmed: 37294173
doi: 10.1039/d3cc00888f
doi:

Substances chimiques

Emulsions 0
DNA 9007-49-2
Oligonucleotides 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8099-8102

Auteurs

Laura Tebcharani (L)

Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, Garching 85748, Germany. job.boekhoven@tum.de.

Nahida Akter (N)

Department of Chemistry, University of Alberta, Edmonton T6G 2G2, Canada.

Di Fan (D)

Center for Protein Assemblies (CPA), Technical University of Munich, Ernst-Otto-Fischer Straße 8, Garching 85748, Germany.
Department of Materials Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstraße 15, Garching 85748, Germany.

Oliver Lieleg (O)

Center for Protein Assemblies (CPA), Technical University of Munich, Ernst-Otto-Fischer Straße 8, Garching 85748, Germany.
Department of Materials Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstraße 15, Garching 85748, Germany.
ORCID: 0000-0002-6874-7456

Julianne M Gibbs (JM)

Department of Chemistry, University of Alberta, Edmonton T6G 2G2, Canada.
ORCID: 0000-0001-5819-2306

Job Boekhoven (J)

Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, Garching 85748, Germany. job.boekhoven@tum.de.
ORCID: 0000-0002-9126-2430

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Hydrolyzable emulsions as a dual release...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Hydrolyzable emulsions as a dual release...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Hydrolyzable emulsions as a dual release...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Hydrolyzable emulsions as a dual release...