Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects.
HCA2 receptor
heart failure
hemodynamics
ketone body
metabolic
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
20 06 2023
20 06 2023
Historique:
medline:
21
6
2023
pubmed:
11
6
2023
entrez:
10
6
2023
Statut:
ppublish
Résumé
Background The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) in patients with heart failure through unknown mechanisms. 3-OHB activates the hydroxycarboxylic acid receptor 2 (HCA
Identifiants
pubmed: 37301762
doi: 10.1161/JAHA.123.029849
pmc: PMC10356045
doi:
Substances chimiques
3-Hydroxybutyric Acid
TZP1275679
Niacin
2679MF687A
Fatty Acids, Nonesterified
0
Hydroxybutyrates
0
Ketone Bodies
0
Prostaglandins
0
Banques de données
ClinicalTrials.gov
['NCT04703361']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029849Références
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