Valorizing Constituents of Cashew Nut Shell Liquid toward the Sustainable Development of New Drugs against Chagas Disease.

Anacardium Sustainable Development Nuts Trypanocidal Agents Chagas Disease / drug therapy Lipids
Trypanosoma cruzi antiparasitic activity cashew nut shell liquid ether phospholipids ultrastructural studies

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
14 07 2023
Historique:
medline: 17 7 2023
pubmed: 12 6 2023
entrez: 12 6 2023
Statut: ppublish

Résumé

Six new ether phospholipid analogues encompassing constituents from cashew nut shell liquid as the lipid portion were synthesized in an effort to valorize byproducts of the cashew industry toward the generation of potent compounds against Chagas disease. Anacardic acids, cardanols, and cardols were used as the lipid portions and choline as the polar headgroup. The compounds were evaluated for their

Identifiants

DOI: 10.1021/acsinfecdis.3c00076 PMID: 37307287
pubmed: 37307287
doi: 10.1021/acsinfecdis.3c00076
doi:

Substances chimiques

Trypanocidal Agents 0
Lipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1334-1345

Auteurs

Laís Flávia Nunes Lemes (LF)

Tropical Medicine Center, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Distrito Federal, Brazil.
Catholic University of Brasilia, QS 07, Lote 01, EPCT, Águas Claras, 71966-700 Brasília, Distrito Federal, Brazil.

George E Magoulas (GE)

Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

Andressa Souza de Oliveira (A)

Department of Pharmacy, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Distrito Federal, Brazil.

Emile Barrias (E)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho s/n, Ilha do Fundão, 21941-900 Rio de Janeiro, Brazil.
Centro Nacional de Biologia Estrutural e Bioimagem, Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho s/n, Ilha do Fundão, 21941-902 Rio de Janeiro, Brazil.

Luciana de Camargo Nascente (L)

Department of Pharmacy, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Distrito Federal, Brazil.

Renato Granado (R)

Laboratory of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology - Inmetro, Rua Santa Alexandrina, 416, Rio Comprido, 20261-232 Rio de Janeiro, Brazil.

Sara Teixeira de Macedo Silva (S)

Centro Nacional de Biologia Estrutural e Bioimagem, Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho s/n, Ilha do Fundão, 21941-902 Rio de Janeiro, Brazil.

Nikos Assimomytis (N)

Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

Wanderley de Souza (W)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho s/n, Ilha do Fundão, 21941-900 Rio de Janeiro, Brazil.
Centro Nacional de Biologia Estrutural e Bioimagem, Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho s/n, Ilha do Fundão, 21941-902 Rio de Janeiro, Brazil.

Maria Laura Bolognesi (ML)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
ORCID: 0000-0002-1289-5361

Luiz Antonio Soares Romeiro (LAS)

Tropical Medicine Center, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Distrito Federal, Brazil.
Department of Pharmacy, Faculty of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Distrito Federal, Brazil.
ORCID: 0000-0001-5679-0820

Theodora Calogeropoulou (T)

Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
ORCID: 0000-0002-3369-5393

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Anacardiaceae › Anacardium › Valorizing Constituents of Cashew Nut Shell...
questionsmedicales.fr › Environnement et santé publique › Environnement › Conservation des ressources naturelles › Développement durable › Valorizing Constituents of Cashew Nut Shell...
questionsmedicales.fr › Aliments et boissons › Aliments › Noix › Valorizing Constituents of Cashew Nut Shell...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Valorizing Constituents of Cashew Nut Shell...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Valorizing Constituents of Cashew Nut Shell...
questionsmedicales.fr › Lipides › Valorizing Constituents of Cashew Nut Shell...