Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum.
3β-OH
EEG
brain development
hypnosis
long-term potentiation
Journal
Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
medline:
17
7
2023
pubmed:
13
6
2023
entrez:
13
6
2023
Statut:
ppublish
Résumé
Preclinical studies have established that neonatal exposure to contemporary sedative/hypnotic drugs causes neurotoxicity in the developing rodent and primate brains. Our group recently reported that novel neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) induced effective hypnosis in both neonatal and adult rodents but did not cause significant neurotoxicity in vulnerable brain regions such as subiculum, an output region of hippocampal formation particularly sensitive to commonly used sedatives/hypnotics. Despite significant emphasis on patho-morphological changes, little is known about long-term effects on subicular neurophysiology after neonatal exposure to neuroactive steroids. Hence, we explored the lasting effects of neonatal exposure to 3β-OH on sleep macrostructure as well as subicular neuronal oscillations
Identifiants
pubmed: 37309730
doi: 10.1177/15353702231177009
pmc: PMC10350800
doi:
Substances chimiques
Neurosteroids
0
Hypnotics and Sedatives
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
578-587Subventions
Organisme : NICHD NIH HHS
ID : R01 HD044517
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD097990
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102525
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD101357
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118197
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD080281
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM141802
Pays : United States
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