Metalloprotein enabled redox signal transduction in microbes.
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
09
03
2023
revised:
21
04
2023
accepted:
26
04
2023
pmc-release:
01
10
2024
medline:
22
9
2023
pubmed:
14
6
2023
entrez:
13
6
2023
Statut:
ppublish
Résumé
Microbes utilize numerous metal cofactor-containing proteins to recognize and respond to constantly fluctuating redox stresses in their environment. Gaining an understanding of how these metalloproteins sense redox events, and how they communicate such information downstream to DNA to modulate microbial metabolism, is a topic of great interest to both chemists and biologists. In this article, we review recently characterized examples of metalloprotein sensors, focusing on the coordination and oxidation state of the metals involved, how these metals are able to recognize redox stimuli, and how the signal is transmitted beyond the metal center. We discuss specific examples of iron, nickel, and manganese-based microbial sensors, and identify gaps in knowledge in the field of metalloprotein-based signal transduction pathways.
Identifiants
pubmed: 37311385
pii: S1367-5931(23)00069-8
doi: 10.1016/j.cbpa.2023.102331
pmc: PMC10524656
mid: NIHMS1896640
pii:
doi:
Substances chimiques
Metalloproteins
0
Metals
0
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102331Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM138277
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ambika Bhagi-Damodaran reports financial support was provided by Regents of the University of Minnesota. Ambika Bhagi-Damodaran reports financial support was provided by National Institutes of Health.
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