Evolutionary and functional history of the Escherichia coli K1 capsule.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 06 2023
15 06 2023
Historique:
received:
28
01
2023
accepted:
26
05
2023
medline:
19
6
2023
pubmed:
16
6
2023
entrez:
15
6
2023
Statut:
epublish
Résumé
Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.
Identifiants
pubmed: 37322051
doi: 10.1038/s41467-023-39052-w
pii: 10.1038/s41467-023-39052-w
pmc: PMC10272209
doi:
Substances chimiques
Virulence Factors
0
Escherichia coli Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3294Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K018396/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N012542/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R009937/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/V006495/1
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
Références
J Bacteriol. 1996 Jun;178(11):3212-20
pubmed: 8655501
Infect Immun. 2004 Oct;72(10):5993-6001
pubmed: 15385503
Nat Commun. 2022 Dec 1;13(1):7417
pubmed: 36456554
J Mol Microbiol Biotechnol. 2009;17(2):71-82
pubmed: 19401610
Nat Commun. 2022 Aug 13;13(1):4751
pubmed: 35963864
Genome Med. 2021 Sep 3;13(1):144
pubmed: 34479643
J Mol Med (Berl). 2016 Feb;94(2):219-33
pubmed: 26411873
Infect Immun. 1994 Oct;62(10):4495-9
pubmed: 7927714
mBio. 2010 Aug 31;1(4):
pubmed: 20827373
Lancet. 1975 May 17;1(7916):1099-104
pubmed: 49468
Rev Infect Dis. 1988 Jul-Aug;10 Suppl 2:S282-6
pubmed: 3055198
Appl Microbiol Biotechnol. 2018 Mar;102(6):2563-2581
pubmed: 29442169
BMC Bioinformatics. 2010 Dec 10;11:595
pubmed: 21143983
Gigascience. 2021 Dec 9;10(12):
pubmed: 34891160
mBio. 2021 Oct 26;12(5):e0251621
pubmed: 34634940
Genome Med. 2015 Sep 28;7:97
pubmed: 26411565
Infect Immun. 2010 Mar;78(3):963-75
pubmed: 20086090
Front Microbiol. 2020 Sep 25;11:2065
pubmed: 33101219
Clin Microbiol Infect. 2020 Feb;26(2):151-157
pubmed: 31712069
Front Cell Infect Microbiol. 2021 Jun 18;11:686090
pubmed: 34222050
J Clin Microbiol. 2018 Mar 26;56(4):
pubmed: 29436416
J Clin Microbiol. 1997 Nov;35(11):2981-2
pubmed: 9350773
Infect Immun. 2010 Feb;78(2):704-15
pubmed: 19948837
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4107-12
pubmed: 11259652
Eur J Biochem. 1988 Oct 15;177(1):117-24
pubmed: 2460347
Infect Immun. 2004 Dec;72(12):7107-14
pubmed: 15557634
J Hyg (Lond). 1985 Dec;95(3):551-75
pubmed: 2419401
Front Immunol. 2022 Feb 11;12:823637
pubmed: 35222358
J Infect Dis. 1977 Aug;136 Suppl:S93-7
pubmed: 330780
Infect Immun. 1991 Feb;59(2):732-6
pubmed: 1898915
Infect Immun. 1986 Mar;51(3):966-8
pubmed: 3512445
Physiol Rev. 2014 Apr;94(2):461-518
pubmed: 24692354
J Antimicrob Chemother. 2005 Jul;56(1):160-5
pubmed: 15914489
mSphere. 2021 Dec 22;6(6):e0086821
pubmed: 34935444
Open Forum Infect Dis. 2020 Oct 17;7(11):ofaa472
pubmed: 33204758
Mol Microbiol. 2006 Aug;61(3):555-9
pubmed: 16879637
Annu Rev Med. 1978;29:129-36
pubmed: 348030
J Infect Dis. 1984 Feb;149(2):184-93
pubmed: 6199436
J Infect Dis. 1979 Jan;139(1):106-8
pubmed: 374636
Clin Infect Dis. 2018 Mar 19;66(7):1004-1012
pubmed: 29136126
PLoS Pathog. 2017 Jul 24;13(7):e1006525
pubmed: 28742161
Biochemistry. 1977 Aug 9;16(16):3687-92
pubmed: 196639
Infect Immun. 1982 Dec;38(3):1149-53
pubmed: 6759406
Mol Microbiol. 2006 May;60(4):828-37
pubmed: 16677296
ISME J. 2020 Jul;14(7):1713-1730
pubmed: 32249276
Microb Genom. 2021 Oct;7(10):
pubmed: 34609275
J Infect Dis. 2009 Jun 1;199(11):1689-97
pubmed: 19432551
Microb Genom. 2018 Jul;4(7):
pubmed: 29916797
Mucosal Immunol. 2020 Jan;13(1):22-33
pubmed: 31719643
Clin Microbiol Infect. 2014 May;20(5):380-90
pubmed: 24766445
J Biol Chem. 2002 May 3;277(18):15607-12
pubmed: 11877402
Antimicrob Agents Chemother. 2004 May;48(5):1503-8
pubmed: 15105097
PLoS Biol. 2021 Jul 6;19(7):e3001276
pubmed: 34228700
Microb Genom. 2021 Feb;7(2):
pubmed: 33417534
Glycoconj J. 1998 Sep;15(9):855-61
pubmed: 10052589
Infect Immun. 1985 May;48(2):486-91
pubmed: 2580792
Infect Immun. 1986 Aug;53(2):339-46
pubmed: 3525410
FEMS Microbiol Rev. 2014 Jul;38(4):660-97
pubmed: 24372337
Microbiol Rev. 1989 Jun;53(2):210-30
pubmed: 2569162
Annu Rev Biochem. 2006;75:39-68
pubmed: 16756484
Genome Res. 2020 Jan;30(1):138-152
pubmed: 31809257
Genome Biol. 2014;15(11):524
pubmed: 25410596
mSphere. 2018 Oct 10;3(5):
pubmed: 30305321
Immunology. 2006 Apr;117(4):482-93
pubmed: 16556262
Nat Commun. 2020 Nov 24;11(1):5968
pubmed: 33235212
Genes Immun. 2021 Oct;22(5-6):255-267
pubmed: 33947987
Infect Immun. 2007 Jul;75(7):3594-603
pubmed: 17470547
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5
pubmed: 10829079
Lancet Microbe. 2021 Jul;2(7):e331-e341
pubmed: 35544167
Mol Microbiol. 1999 Mar;31(5):1307-19
pubmed: 10200953
Infect Immun. 1998 Nov;66(11):5183-9
pubmed: 9784520
Front Immunol. 2017 Apr 20;8:452
pubmed: 28473832
Science. 2001 Dec 7;294(5549):2170-2
pubmed: 11739958
Infect Immun. 1996 Aug;64(8):3210-7
pubmed: 8757855
J Bacteriol. 2005 Dec;187(24):8499-503
pubmed: 16321955
Genome Biol. 2015 Dec 29;16:294
pubmed: 26714481
Sci Rep. 2021 Jun 16;11(1):12728
pubmed: 34135355
Infect Immun. 1999 Aug;67(8):3757-62
pubmed: 10417134
Mol Microbiol. 2004 Jun;52(5):1329-36
pubmed: 15165236
Antimicrob Agents Chemother. 2015 Apr;59(4):1983-91
pubmed: 25605353
Infect Immun. 1983 Dec;42(3):907-13
pubmed: 6196296
Infect Immun. 2015 Jul;83(7):2605-13
pubmed: 25870229
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7997-8002
pubmed: 19416883
PLoS Genet. 2006 Mar;2(3):e31
pubmed: 16532061
Eur J Biochem. 1981 May 15;116(2):359-64
pubmed: 7018909
J Immunol Methods. 2004 Dec;295(1-2):149-60
pubmed: 15627620
Microbiology (Reading). 2010 Jul;156(Pt 7):2205-2215
pubmed: 20395269
Genome Med. 2021 May 5;13(1):77
pubmed: 33952335
Science. 2016 Apr 29;352(6285):544-5
pubmed: 27126037
Annu Rev Microbiol. 1996;50:285-315
pubmed: 8905082
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
PLoS One. 2009;4(3):e4752
pubmed: 19270734
J Bacteriol. 1961 Dec;82:838-48
pubmed: 13885921
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5694-9
pubmed: 24706808
Nucleic Acids Res. 2018 Dec 14;46(22):e134
pubmed: 30184106
Infect Immun. 2010 Feb;78(2):716-25
pubmed: 19948838
J Infect Dis. 1973 Jun;127(6):670-7
pubmed: 4196446
Microbiology (Reading). 2008 Dec;154(Pt 12):3877-3886
pubmed: 19047754
J Bacteriol. 1992 Dec;174(23):7757-61
pubmed: 1447142
J Clin Microbiol. 2004 Mar;42(3):1203-6
pubmed: 15004076
Sci Rep. 2017 Dec;7(1):83
pubmed: 28250440
Microbiology (Reading). 2008 Aug;154(Pt 8):2522-2532
pubmed: 18667585
Infect Immun. 2001 Jul;69(7):4248-56
pubmed: 11401961
Genome Biol. 2020 Jul 22;21(1):180
pubmed: 32698896
Curr Top Microbiol Immunol. 2018;416:213-242
pubmed: 30062594
Nature. 1957 Jan 26;179(4552):206
pubmed: 13400142
Bioinformatics. 2021 Aug 25;37(16):2473-2475
pubmed: 33459763
Appl Environ Microbiol. 2005 Aug;71(8):4872-4
pubmed: 16085886
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Lancet Glob Health. 2018 Sep;6(9):e969-e979
pubmed: 30103998
Microb Genom. 2016 Nov 30;2(11):e000093
pubmed: 28348833
Genome Res. 2017 Jul 18;:
pubmed: 28720578
Microb Pathog. 2006 Dec;41(6):207-17
pubmed: 16954050
J Bacteriol. 2007 Feb;189(4):1231-7
pubmed: 16997964
Bioinformatics. 2014 Jul 15;30(14):2068-9
pubmed: 24642063
FEMS Microbiol Lett. 2001 May 15;199(1):61-6
pubmed: 11356568
Infect Immun. 1982 Sep;37(3):956-60
pubmed: 6752031
J Bacteriol. 2004 May;186(10):3086-96
pubmed: 15126470
Mol Microbiol. 2000 Oct;38(1):53-66
pubmed: 11029690
Nucleic Acids Res. 2015 Feb 18;43(3):e15
pubmed: 25414349