Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo.
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
05
08
2022
accepted:
12
05
2023
medline:
27
11
2023
pubmed:
16
6
2023
entrez:
15
6
2023
Statut:
ppublish
Résumé
Autophagy is a cellular process with important functions that drive neurodegenerative diseases and cancers. Lysosomal hyperacidification is a hallmark of autophagy. Lysosomal pH is currently measured by fluorescent probes in cell culture, but existing methods do not allow for quantitative, transient or in vivo measurements. In the present study, we developed near-infrared optical nanosensors using organic color centers (covalent sp
Identifiants
pubmed: 37322156
doi: 10.1038/s41589-023-01364-9
pii: 10.1038/s41589-023-01364-9
doi:
Substances chimiques
Nanotubes, Carbon
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1448-1457Subventions
Organisme : NIBIB NIH HHS
ID : K99 EB033580
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM141949
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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