Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing.
Plasmodium ovale wallikeri
WGS
microsatellites
relapses
sWGA
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
18 10 2023
18 10 2023
Historique:
received:
09
03
2023
accepted:
15
06
2023
medline:
23
10
2023
pubmed:
17
6
2023
entrez:
17
6
2023
Statut:
ppublish
Résumé
Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp.
Identifiants
pubmed: 37329228
pii: 7199853
doi: 10.1093/infdis/jiad216
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1089-1098Investigateurs
Ahmed Aboubacar
(A)
Cécile Angebault
(C)
Adela Angoulvant
(A)
Nicolas Argy
(N)
Daniel Azjenberg
(D)
Ghania Belkadi
(G)
Anne-Pauline Bellanger
(AP)
Dieudonné Bemba
(D)
Marion Blaize
(M)
Françoise Botterel
(F)
Marie-Elisabeth Bougnoux
(ME)
Sophie Brun
(S)
Bernadette Buret
(B)
Sylviane Chevrier
(S)
Sylvain Clauser
(S)
Naima Dahane
(N)
Eric Dannaoui
(E)
Céline Dard
(C)
Marie-Laure Dardé
(ML)
Ludovic de Gentile
(L)
Nathalie de Suremain
(N)
Anne Debourgogne
(A)
Anne Delaval
(A)
Anne-Sophie Deleplancque
(AS)
Guillaume Desoubeaux
(G)
Rémy Durand
(R)
Marie-Fleur Durieux
(MF)
Emmanuel Dutoit
(E)
Odile Eloy
(O)
Odile Fenneteau
(O)
Gilles Gargala
(G)
Nadine Godineau
(N)
Nadia Guennouni
(N)
Jérôme Guinard
(J)
Samia Hamane
(S)
Etienne Herault
(E)
Sébastien Larreché
(S)
Rose-Anne Lavergne
(RA)
Anthony Marteau
(A)
Edith Mazars
(E)
Alicia Moreno-Sabater
(A)
Florent Morio
(F)
Céline Nourrisson
(C)
Estelle Perraud-Cateau
(E)
Denis Pons
(D)
Lauren Pull
(L)
Dorothée Quinio
(D)
Didier Raffenot
(D)
Muriel Silva
(M)
Marc Thellier
(M)
Alexandra Tielli
(A)
Dominique Toubas
(D)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Déclaration de conflit d'intérêts
Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.