Advanced strategies for metabolic engineering of Bacillus to produce extracellular polymeric substances.

Bacillus / genetics Extracellular Polymeric Substance Matrix / metabolism Metabolic Engineering Metabolic Networks and Pathways Bacteria / metabolism Polyglutamic Acid / genetics
Extracellular polymeric substances biosynthesis exopolysaccharides metabolic engineering poly-γ-glutamic acid

Journal

Biotechnology advances
ISSN: 1873-1899
Titre abrégé: Biotechnol Adv
Pays: England
ID NLM: 8403708

Informations de publication

Date de publication:
10 2023
Historique:
received: 05 03 2023
revised: 24 05 2023
accepted: 11 06 2023
medline: 14 8 2023
pubmed: 18 6 2023
entrez: 17 6 2023
Statut: ppublish

Résumé

Extracellular polymeric substances are mainly synthesized via a variety of biosynthetic pathways in bacteria. Bacilli-sourced extracellular polymeric substances, such as exopolysaccharides (EPS) and poly-γ-glutamic acid (γ-PGA), can serve as active ingredients and hydrogels, and have other important industrial applications. However, the functional diversity and widespread applications of these extracellular polymeric substances, are hampered by their low yields and high costs. Biosynthesis of extracellular polymeric substances is very complex in Bacillus, and there is no detailed elucidation of the reactions and regulations among various metabolic pathways. Therefore, a better understanding of the metabolic mechanisms is required to broaden the functions and increase the yield of extracellular polymeric substances. This review systematically summarizes the biosynthesis and metabolic mechanisms of extracellular polymeric substances in Bacillus, providing an in-depth understanding of the relationships between EPS and γ-PGA synthesis. This review provides a better clarification of Bacillus metabolic mechanisms during extracellular polymeric substance secretion and thus benefits their application and commercialization.

Identifiants

DOI: 10.1016/j.biotechadv.2023.108199 PMID: 37330153
pubmed: 37330153
pii: S0734-9750(23)00106-4
doi: 10.1016/j.biotechadv.2023.108199
pii:
doi:

Substances chimiques

Polyglutamic Acid 25513-46-6

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108199

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest.

Auteurs

Xiaoyu Wei (X)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China.

Zhen Chen (Z)

College of Life Science, Xinyang Normal University, Xinyang 464000, China. Electronic address: chenzhen@xynu.edu.cn.

Ailing Liu (A)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China.

Lijie Yang (L)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China.

Yiyuan Xu (Y)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China.

Mingfeng Cao (M)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China; Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China. Electronic address: mfcao@xmu.edu.cn.

Ning He (N)

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen 361005, China. Electronic address: hening@xmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Advanced strategies for metabolic engineering...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Matrice de substances polymériques extracellulaires › Advanced strategies for metabolic engineering...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Advanced strategies for metabolic engineering...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Advanced strategies for metabolic engineering...
questionsmedicales.fr › Bactéries › Advanced strategies for metabolic engineering...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Acide polyglutamique › Advanced strategies for metabolic engineering...