Metabolic flux phenotyping of secondary metabolism in cyanobacteria.

Secondary Metabolism Metabolic Engineering Photosynthesis Metabolic Networks and Pathways / genetics Cyanobacteria / genetics
genome-scale metabolic models metabolic flux analysis secondary metabolism secondary metabolites systems metabolic engineering

Journal

Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916

Informations de publication

Date de publication:
11 2023
Historique:
received: 13 02 2023
revised: 10 05 2023
accepted: 15 05 2023
medline: 23 10 2023
pubmed: 19 6 2023
entrez: 18 6 2023
Statut: ppublish

Résumé

Cyanobacteria generate energy from photosynthesis and produce various secondary metabolites with diverse commercial and pharmaceutical applications. Unique metabolic and regulatory pathways in cyanobacteria present new challenges for researchers to enhance their product yields, titers, and rates. Therefore, further advancements are critically needed to establish cyanobacteria as a preferred bioproduction platform. Metabolic flux analysis (MFA) quantitatively determines the intracellular flows of carbon within complex biochemical networks, which elucidate the control of metabolic pathways by transcriptional, translational, and allosteric regulatory mechanisms. The emerging field of systems metabolic engineering (SME) involves the use of MFA and other omics technologies to guide the rational development of microbial production strains. This review highlights the potential of MFA and SME to optimize the production of cyanobacterial secondary metabolites and discusses the technical challenges that lie ahead.

Identifiants

DOI: 10.1016/j.tim.2023.05.005 PMID: 37331829
pubmed: 37331829
pii: S0966-842X(23)00158-0
doi: 10.1016/j.tim.2023.05.005
pii:
doi:

Types de publication

Journal Article Review Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1118-1130

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.

Auteurs

Piyoosh K Babele (PK)

College of Agriculture, Rani Lakshmi Bai Central Agricultural University Jhansi, 284003, Uttar Pradesh, India. Electronic address: piyoosh.bhu06@gmail.com.

Amit Srivastava (A)

University of Jyväskylä, Nanoscience Centre, Department of Biological and Environmental Science, 40014 Jyväskylä, Finland.

Jamey D Young (JD)

Department of Chemical and Biomolecular Engineering, Vanderbilt University, PMB 351604, Nashville, TN 37235-1604, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, PMB 351604, Nashville, TN 37235-1604, USA. Electronic address: j.d.young@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Métabolisme secondaire › Metabolic flux phenotyping of secondary...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Metabolic flux phenotyping of secondary...
questionsmedicales.fr › Phénomènes physiologiques des plantes › Photosynthèse › Metabolic flux phenotyping of secondary...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Metabolic flux phenotyping of secondary...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries à Gram négatif photosynthétiques › Cyanobactéries › Metabolic flux phenotyping of secondary...